Article
Biochemistry & Molecular Biology
Eduardo Lopez-Huertas, Juan M. Alcaide-Hidalgo
Summary: This study investigated the composition of low molecular weight peptides in virgin olive oil and identified new peptides originating from seed storage proteins. These peptides were found to possess antioxidant and ACE-inhibitory activities, suggesting their potential importance in determining the quality of virgin olive oil.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jianting Ning, Mohan Li, Weiyan Chen, Huiwen Zhao, Jiali Chen, Mei Yang, Xueyan Cao, Xiqing Yue
Summary: This paper reviews the research progress and applications of endogenous peptides in milk and milk-related products using peptidomics analysis. It discusses the limitations of methods for probing endogenous peptides and introduces new methodologies for studying peptides through bioinformatics. The paper also explores tracking the release of bioactive peptides from various milk sources and discusses challenges and future perspectives.
Article
Biochemistry & Molecular Biology
Kelly A. Dingess, Inge Gazi, Henk W. P. van den Toorn, Marko Mank, Bernd Stahl, Karli R. Reiding, Albert J. R. Heck
Summary: Human milk contains beta-casein, a protein that undergoes post-translational modifications such as phosphorylation and glycosylation. A study observed changes in phosphorylation and previously unexplored O-glycosylation of beta-casein in two donors over 16 weeks of lactation, indicating the importance of these modifications on antimicrobial peptides derived from beta-casein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Andrea Cerrato, Sara Elsa Aita, Chiara Cavaliere, Aldo Lagana, Carmela Maria Montone, Susy Piovesana, Riccardo Zenezini Chiozzi, Anna Laura Capriotti
Summary: The study analyzed native peptides from sea bass muscle using two different approaches: peptidomics analysis for medium-sized peptides and suspect screening analysis for short peptides. The method can also be extended to any peptide mixture from other food matrices.
Article
Biochemistry & Molecular Biology
Carmela Maria Montone, Sara Elsa Aita, Chiara Cavaliere, Andrea Cerrato, Aldo Lagana, Susy Piovesana, Anna Laura Capriotti
Summary: The process of cheese-making is a longstanding tradition in human food culture, with dairy being a major sector of the food industry. Revalorizing milk whey is a primary goal in alignment with circular economy principles. Research shows that whole and skimmed whey contain higher levels of short bioactive peptides compared to whole milk, with a unique composition likely generated during the cheese-making process.
Article
Nutrition & Dietetics
Maryam Atef, Yasmina Ait Chait, Seyed Mahdi Ojagh, Ali Mohammad Latifi, Mina Esmaeili, Riadh Hammami, Chibuike C. Udenigwe
Summary: Peptide fractions from fish skin collagen showed antibacterial activity against Escherichia coli and Salmonella strains, with papain hydrolysate demonstrating the best activity against E. coli. After acetone fractionation, the peptide fractions from Neutrase and papain hydrolysates exhibited enhanced dose-dependent inhibition of the growth of four Salmonella strains.
Article
Food Science & Technology
Jiayu Zhang, Mengdi Li, Ying Lv, Shuntang Guo, Baichong Yang
Summary: The study investigated the protein aggregates and in vitro digestibility of soymilk, as well as dry-heated soybeans (DHS) at 160 degrees C and 200 degrees C. The results showed that thermal treatment led to the formation of different types of insoluble protein aggregates. The in vitro digestibility was higher for 160 degrees C DHS compared to soymilk and 200 degrees C DHS.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
James W. Checco
Summary: Peptidomics is an underutilized method that uses mass spectrometry to identify and measure endogenous peptides, which play crucial biological roles and have potential as biomarkers. This article serves as a brief introduction to peptidomics, aiming to raise awareness and encourage its application among researchers interested in studying endogenous peptides.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Applied
Deborah C. Freitas, Rafael A. Zambelli, Marcio Ramos, Joao P. B. Oliveira, Pedro F. N. Souza, Glauber B. M. Santos, Celso S. Nagano, Leandro P. Bezerra, Ayrles F. B. Silva, Jefferson S. Oliveira, Cleverson D. T. Freitas
Summary: The study demonstrated that antimicrobial peptides generated from the hydrolysis of wheat gluten proteins using latex peptidases showed inhibitory effects on various fungi and delayed fungal growth on bread. Synthesized peptides exhibited activity against Penicillium sp., damaging the fungal plasma membrane without toxicity.
Article
Chemistry, Applied
Ting Zhang, Ying Hua, Changyu Zhou, Yongzhao Xiong, Daodong Pan, Zhu Liu, Yali Dang
Summary: A high-throughput screening method for umami peptides was established in this study, using mass spectrometry and virtual screening, and validated using sensory evaluation and electronic tongue. The results showed that the method can rapidly screen peptides with umami characteristics and identify key active sites associated with flavor presentation. This has important implications for screening umami peptides and evaluating umami taste.
Article
Genetics & Heredity
Tingting Chen, Zhongxiao Zhang, Qin Lu, Jun Ma
Summary: In this study, the peptidome of human placental tissues was analyzed and compared between healthy pregnant women and those with mild or severe preeclampsia. Differential expression of peptides was found in both preeclampsia groups, and functional analysis suggested their involvement in crucial biological processes, particularly the transforming growth factor-beta/Smad signaling pathway. These findings indicate the potential role of placental bioactive peptides in regulating placental function during preeclampsia progression.
FRONTIERS IN GENETICS
(2022)
Article
Agriculture, Multidisciplinary
Mingyang Li, Wenlai Fan, Yan Xu
Summary: A comprehensive method using traditional and peptidomics approaches was used to identify low-molecular weight peptides and medium-sized peptides in Pixian broad bean paste alcalase hydrolysates. This study provides important knowledge about bioactive peptides in complex food matrices.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Katarzyna Tarnowska, Eliza Gruczynska-Sekowska, Dorota Kowalska, Ewa Majewska, Mariola Kozlowska, Renata Winkler
Summary: Autism spectrum disorders are highly variable neurodevelopmental disorders. The exact cause is still unknown, but a commonly used intervention is the gluten-free casein-free diet based on the opioid excess theory.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Wendell Albuquerque, Parviz Ghezellou, Kwang-Zin Lee, Quintus Schneider, Phillip Gross, Tobias Kessel, Bodunrin Omokungbe, Bernhard Spengler, Andreas Vilcinskas, Holger Zorn, Martin Gand
Summary: In this study, the researchers used model wine haze proteins and confirmed that peptidases from Drosophila suzukii larvae can degrade the proteins under acidic conditions. The combination of mass spectrometry and protein modeling allowed for the visualization of cleavage sites. This research provides a valuable screening tool for finding optimal peptidases for wine clarification processes.
Article
Biochemistry & Molecular Biology
Chiara Cavaliere, Angela Michela Immacolata Montone, Sara Elsa Aita, Rosanna Capparelli, Andrea Cerrato, Paola Cuomo, Aldo Lagana, Carmela Maria Montone, Susy Piovesana, Anna Laura Capriotti
Summary: This paper aimed to comprehensively characterize peptides obtained from soybean protein digestion, with a focus on identifying antioxidant peptides. Two analytical approaches were used to analyze medium-sized and short peptides, leading to the discovery of potential antioxidant amino acid sequences in certain fractions.