Article
Multidisciplinary Sciences
David O. 'Sullivan, Michal A. Stanczak, Matteo Villa, Franziska M. Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks, Katarzyna M. Grzes, Agnieszka M. Kabat, Ryan L. Kyle, Mario Fabri, Jonathan D. Curtis, Michael D. Buck, Annette E. Patterson, Annamaria Regina, Cameron S. Field, Francesc Baixauli, Daniel J. Puleston, Edward J. Pearce, Robert Zeiser, Erika L. Pearce
Summary: Fever can enhance metabolic activity and effector functions of activated CD8* T cells, with limited effects on proliferation or activation marker expression. Exposure to 39 degrees Celsius increases mass and metabolism in T cells, with mitochondrial translation playing a crucial role in the enhanced metabolic activity and function observed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Janine Kemming, Swantje Gundlach, Marcus Panning, Daniela Huzly, Jiabin Huang, Marc Luetgehetmann, Sven Pischke, Julian Schulze Zur Wiesch, Florian Emmerich, Sian Llewellyn-Lacey, David A. Price, Yakup Tanriver, Klaus Warnatz, Tobias Boettler, Robert Thimme, Maike Hofmann, Nicole Fischer, Christoph Neumann-Haefelin
Summary: Chronic HEV infection is associated with exhaustion of HEV-specific CD8+ T cells, indicating that T-cell failure is driven by persistent antigen recognition in severely immunosuppressed hosts. Functional reinvigoration of virus-specific T cells is at least partially possible when the antigen is cleared. Viral escape in a minority of patients also contributes to the failure of HEV-specific CD8+ T cells.
JOURNAL OF HEPATOLOGY
(2022)
Review
Immunology
Arianne C. Richard
Summary: The advent of technologies that can characterize individual cells has revealed extensive diversity between cells of the same subset, including CD8(+) T cells. This review focuses on heterogeneity in CD8(+) T cell responses, particularly the impact of TCR stimulation strength and the mechanisms underlying variation between cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Maike Hofmann, Catrin Tauber, Nina Hensel, Robert Thimme
Summary: CD8(+) T cell responses play a crucial role in chronic HCV infection and HCC, strong virus-specific CD8(+) T cell responses contribute to virus clearance while failure leads to chronic infection development. Tumor-associated and tumor-specific CD8(+) T cells are considered potential targets for immunotherapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Wai Ki Wong, Bohan Yin, Ching Ying Katherine Lam, Yingying Huang, Jiaxiang Yan, Zhiwu Tan, Siu Hong Dexter Wong
Summary: This article discusses the importance of epigenetic regulation of T-cell function in cancer immunotherapy and how to restore their function by modulating the epigenetic switches of T-cells, providing new therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ajinkya Pattekar, Lena S. Mayer, Chi Wai Lau, Chengyang Liu, Olesya Palko, Meenakshi Bewtra, Hpap Consortium, Lisa C. Lindesmith, Paul D. Brewer-Jensen, Ralph S. Baric, Michael R. Betts, Ali Naji, E. John Wherry, Vesselin T. Tomov
Summary: The study identified immune correlates of NoV protection and persistence and defined the breadth, distribution, and properties of human NoV-specific T-cell immunity, especially in the intestinal mucosa. These findings can guide the development of future vaccines and novel cellular therapeutics.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan Yan, Wei Zhao, Wei Liu, Yan Li, Xu Wang, Jingna Xun, Chantsalmaa Davgadorj
Summary: CCL19 enhances Ag-responsive IFN-γ(+) CD8(+) T cells in patients with HBV infection and promotes rapid clearance of intrahepatic HBV in mice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Kerstin M. Gergely, Juergen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Buescher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: The study demonstrates that combining ACT and TherVac in HCT recipients significantly improves antiviral control, and the enhancement of antiviral protection through vaccination is strictly epitope-specific.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Haiyang Lu, Fangming Liu, Yao Li, Jiahui Wang, Mingyue Ma, Jie Gao, Xiangdong Wang, Zan Shen, Duojiao Wu
Summary: The study revealed that chromatin openness in CD8(+)T cell subsets is associated with metabolic regulation, with the upstream binding site SP1 playing a critical role in fatty acid oxidation and glycolysis. The differential presence of accessible regions in CD8(+)T cell subsets provides a novel perspective for understanding the epigenetic mechanisms underlying T cell differentiation and related immune response.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Review
Immunology
Peter Aichele, Christoph Neumann-Haefelin, Stephan Ehl, Robert Thimme, Toni Cathomen, Melanie Boerries, Maike Hofmann
Summary: The root cause of immunopathologies lies in impaired immune responses, rather than exaggerated immune responses; The focus of research is on impaired immune reactions mediated by CD8(+) T cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
David G. Brooks, Antoinette Tishon, Michael B. A. Oldstone, Dorian B. McGavern
Summary: During chronic viral infections, CD8 T cells can rapidly lose antiviral and immune-stimulatory functions and be physically deleted, but therapeutic strategies such as lowering viral replication and utilizing CD4 T cell help can prevent CD8 T cell deletion and enhance their diversity and function.
Article
Biochemistry & Molecular Biology
Marta Gomez-Perosanz, Jose L. Sanchez-Trincado, Miguel Fernandez-Arquero, John Sidney, Alessandro Sette, Esther M. Lafuente, Pedro A. Reche
Summary: This study identified and characterized 23 conserved HRV-specific CD8 T cell epitopes on PBMCs from 14 HLA I typed subjects, confirming peptide-specific IFN gamma production and binding to the relevant HLA I for nine of these epitopes. The study also validated cytotoxicity mediated by A*02:01-restricted epitopes and discovered an unusually long 16-mer epitope peptide restricted by A*02:01. These HRV-specific CD8 T cell epitopes are expected to elicit CD8 T cell responses in up to 87% of the population and could be crucial for developing an HRV vaccine.
Article
Cell Biology
Brendan E. Russ, Adele Barugahare, Pushkar Dakle, Kirril Tsyganov, Sara Quon, Bingfei Yu, Jasmine Li, Jason K. C. Lee, Moshe Olshansky, Zhaohren He, Paul F. Harrison, Michael See, Simone Nussing, Alison E. Morey, Vibha A. Udupa, Taylah J. Bennett, Axel Kallies, Cornelis Murre, Phillipe Collas, David Powell, Ananda W. Goldrath, Stephen J. Turner
Summary: The differentiation of naive CD8+ T lymphocytes into effector and memory cells involves large-scale changes in genome organization. This study used Hi-C to map the spatial organization of genome contacts in naive, effector, and memory CD8+ T cells and found distinctive architectural differences. Key transcription factors, such as BACH2 and SATB1, were shown to play a role in maintaining the naive chromatin state and restraining T cell differentiation.
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ryan Zander, Moujtaba Y. Kasmani, Yao Chen, Paytsar Topchyan, Jian Shen, Shikan Zheng, Robert Burns, Jennifer Ingram, Can Cui, Nikhil Joshi, Joseph Craft, Allan Zajac, Weiguo Cui
Summary: This study found that CD4(+) T cells consist of three distinct subsets during chronic viral infection, and IL-21 derived from Tfh cells is critical for sustaining CD8(+) T cell responses and viral control.
