Article
Gastroenterology & Hepatology
Masashi Ninomiya, Jun Inoue, Eugene W. Krueger, Jing Chen, Hong Cao, Atsushi Masamune, Mark A. McNiven
Summary: This study found that the tetraspanin protein CD63 is associated with HBV during viral infection and shedding, and may play an important role in the formation and release of infectious HBV particles.
HEPATOLOGY COMMUNICATIONS
(2021)
Review
Cell Biology
Kate Dicker, Aino I. Jarvelin, Manuel Garcia-Moreno, Alfredo Castello
Summary: RNA viruses rely on cellular RNA-binding proteins to facilitate replication and spread, with a pool of RBPs typically incorporated into viral particles. These RBPs play crucial roles in viral particle formation and infectivity, suggesting broader implications for host RBPs in virus infection than previously thought.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wenshi Wang, Florian A. Lempp, Franziska Schlund, Lisa Walter, Charlotte C. Decker, Zhenfeng Zhang, Yi Ni, Stephan Urban
Summary: Research has shown that HDVs from different genotypes replicate with varying efficacies. Variations in HDV genomes and HBV envelope proteins are major determinants of HDV egress and entry efficacy.
JOURNAL OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cyrine Bentaleb, Kevin Hervouet, Claire Montpellier, Charline Camuzet, Martin Ferrie, Julien Burlaud-Gaillard, Stephane Bressanelli, Karoline Metzger, Elisabeth Werkmeister, Maliki Ankavay, Nancy Leon Janampa, Julien Marlet, Julien Roux, Clarence Deffaud, Anne Goffard, Yves Rouille, Jean Dubuisson, Philippe Roingeard, Cecile-Marie Aliouat-Denis, Laurence Cocquerel
Summary: Despite being a major cause of viral hepatitis worldwide, many aspects of the hepatitis E virus (HEV) lifecycle remain poorly understood. In this study, researchers generated specific antibodies to identify different forms of the HEV capsid protein. They discovered subcellular structures enriched with viral proteins and RNA, as well as a membrane network induced by HEV infection. This network depended on the capsid protein assembly and expression of a specific viral protein. The study provides new insights into the replication process of HEV and its interactions with cellular compartments.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Microbiology
Fernando Villalon-Letelier, Andrew G. Brooks, Sarah L. Londrigan, Patrick C. Reading
Summary: MARCH8 restricts influenza A virus at a late stage in replication by reducing incorporation of envelope glycoproteins into virions, demonstrating a unique mechanism of antiviral activity. The N-terminal cytoplasmic domain of MARCH8 is essential for this anti-IAV activity, distinguishing it from MARCH1.
Article
Biology
Lea Buehler, Adriano Maida, Elena Sophie Vogl, Anastasia Georgiadi, Andrea Takacs, Oliver Kluth, Annette Schuermann, Annette Feuchtinger, Christine von Toerne, Foivos-Filippos Tsokanos, Katarina Klepac, Gretchen Wolff, Minako Sakurai, Bilgen Ekim Uestuenel, Peter Nawroth, Stephan Herzig
Summary: Members of the lipocalin protein family have potential as biomarkers for kidney disease and acute phase inflammatory reactions, but face challenges in clinical development due to their complex biological activity and lack of mechanistic knowledge.
LIFE SCIENCE ALLIANCE
(2021)
Article
Virology
Yu You, Andele M. Conradie, Ahmed Kheimar, Luca D. Bertzbach, Benedikt B. Kaufer
Summary: The study reveals the role of the MDV082 protein in the pathogenesis of Marek's disease, showing that while not essential, it contributes to the rapid onset of the disease.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keith Saunders, Eva C. Thuenemann, Hadrien Peyret, George P. Lomonossoff
Summary: The presence of the origin of assembly sequence (OAS) is necessary for the specific encapsidation of replicating viral RNA, providing a unique site for the initiation of viral assembly and leading to the formation of specific nucleoprotein nanorods.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Farzaneh Mohajerani, Botond Tyukodi, Christopher J. Schlicksup, Jodi A. Hadden-Perilla, Adam Zlotnick, Michael F. Hagan
Summary: In this study, computer simulations and analysis were used to reveal the assembly process of hepatitis B virus (HBV) and the mechanism of capsid polymorphism. The findings are important for understanding the HBV lifecycle and developing new antiviral drugs.
Article
Multidisciplinary Sciences
Chiao-Fang Teng, Tsai-Chung Li, Ting Wang, Da-Ching Liao, Yi-Hsuan Wen, Tzu-Hua Wu, John Wang, Han-Chieh Wu, Woei-Cherng Shyu, Ih-Jen Su, Long-Bin Jeng
Summary: Hepatocellular carcinoma (HCC) is closely associated with chronic hepatitis B virus (HBV) infection. The oncoprotein pre-S2 mutant plays important roles in HCC development and is linked to poor prognosis in HCC patients. In pre-S2 mutant-positive HCC patients, there is a higher infiltration of regulatory T cells (Tregs) but a lower infiltration of cytotoxic T lymphocytes (CTLs) in tumor tissues.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Adrienne E. H. Shearer, Kalmia E. Kniel
Summary: The study found that plant-derived proteases, including bromelain, papain, and ficin, had limited efficacy in inactivating hepatitis A virus (HAV), Tulane virus (TV), and murine norovirus (MNV) even at elevated temperatures and exposure times. The varying susceptibilities observed between TV and MNV highlight challenges in predicting pathogen behavior for specific treatment structures.
JOURNAL OF FOOD PROTECTION
(2021)
Article
Virology
Caitlin Pley, Jose Lourenco, Anna L. McNaughton, Philippa C. Matthews
Summary: This study explores the role of the spacer sequence in HBV evolution and lineage, its associations with drug and immune evasion, and potential impacts on disease outcomes.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Wei-Cheng Huang, Yu-Chen Lin, Po-Ju Chen, Nien-Tzu Hsu, Chia-Ling Tu, Te-Sheng Chang, Chao-Hung Hung, Kwong-Ming Kee, Wen-Hua Chao, Sheng-Nan Lu
Summary: Screening and linkage to care are crucial in achieving viral hepatitis elimination by 2030. By using quantitative antigen screening in a community-based setting, two hyperendemic townships were identified, aiding in the control of viral hepatitis transmission.
Article
Gastroenterology & Hepatology
Maud Michelet, Dulce Alfaiate, Brieux Chardes, Caroline Pons, Suzanne Faure-Dupuy, Thomas Engleitner, Rayan Farhat, Tobias Riedl, Anne-Flore Legrand, Roland Rad, Michel Rivoire, Fabien Zoulim, Mathias Heikenwalder, Anna Salvetti, David Durantel, Julie Lucifora
Summary: This study analyzed the effect of several innate immune stimulators on HDV replication in infected hepatocytes. The researchers found that immune-modulators triggering the NF-kappa B pathways can inhibit HDV replication and may be a potential therapeutic approach for chronically HBV/HDV-infected patients.
Article
Microbiology
Dara Burdette, Anastasia Hyrina, Zhijuan Song, Rudolf K. Beran, Tara Cheung, Sarah Gilmore, Tetsuya Kobayashi, Li Li, Yang Liu, Anita Niedziela-Majka, Jonathan Medley, Upasana Mehra, Philip Morganelli, Nikolai Novikov, Congrong Niu, Danny Tam, Jennifer Tang, Jianhong Wang, Qin Yue, Simon P. Fletcher, Meghan M. Holdorf, William E. Delaney, Becket Feierbach, Scott Lazerwith
Summary: The standard treatment for chronic hepatitis B involves lifelong use of nucleos(t)ide analogs (NAs) to suppress viral replication. However, these agents fail to cure most patients and infectious virus can still be detected in virally suppressed patients. Therefore, new antiviral treatment options are being developed to enhance the suppression of hepatitis B virus (HBV) replication. GS-SBA-1, a capsid assembly modulator (CAM), demonstrated potent inhibition of extracellular HBV DNA both in vitro and in vivo, and showed comparable activities across different HBV genotypes and drug-resistant mutants. GS-SBA-1 also showed additive effects in combination with tenofovir alafenamide (TAF). Furthermore, GS-SBA-1 prevented the formation of covalently closed circular DNA (cccDNA) and decreased HBV RNA and antigen levels, as well as the production of extracellular HBV RNA-containing viral particles in vitro.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Cell Biology
Marie Febvre-James, Valerie Lecureur, Olivier Fardel
INFLAMMATION RESEARCH
(2020)
Article
Entomology
Johan Sebastian Portilla-Pulido, Ruth Mariela Castillo-Morales, Mario Alberto Baron-Rodriguez, Jonny Edward Duque, Stelia Carolina Mendez-Sanchez
JOURNAL OF MEDICAL ENTOMOLOGY
(2020)
Article
Chemistry, Medicinal
Kristina Forsch, Verena Schoening, Greta Marie Assmann, Christin Moser, Beate Siewert, Veronika Butterweck, Juergen Drewe
PHYTOTHERAPY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jessica Dietrich, Magdalena Schindler, Alfonso Lampen, Albert Braeuning, Stefanie Hessel-Pras
CHEMICO-BIOLOGICAL INTERACTIONS
(2020)
Article
Biotechnology & Applied Microbiology
Aziza A. A. Adam, Aldo Jongejan, Perry D. Moerland, Vincent A. van der Mark, Ronald P. Oude Elferink, Robert A. F. M. Chamuleau, Ruurdtje Hoekstra
Article
Pharmacology & Pharmacy
Dianke Yu, Jing Chen, Si Chen, Lin Xu, Leihong Wu, Dongying Li, Jiao Luo, Yuan Jin, Yanjie Zhao, Bridgett Knox, William H. Tolleson, Xubing Wang, Lei Guo, Weida Tong, Baitang Ning
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Environmental Sciences
Lin Yu, Hequn Li, Chi Zhang, Qiang Zhang, Jiabin Guo, Jin Li, Haitao Yuan, Lizhong Li, Paul Carmichael, Shuangqing Peng
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Lea Wagmann, Sascha K. Manier, Thomas P. Bambauer, Christina Felske, Niels Eckstein, Veit Flockerzi, Markus R. Meyer
JOURNAL OF ANALYTICAL TOXICOLOGY
(2020)
Article
Genetics & Heredity
Yuqi Wei, Cong Huai, Chenxi Zhou, Yaqi Gao, Luan Chen, Wei Zhou, Muyun Wei, Shengying Qin
PHARMACOGENOMICS JOURNAL
(2020)
Article
Multidisciplinary Sciences
Angela Zhang, Cindy Yanfei Li, Edward J. Kelly, Lianne Sheppard, Julia Yue Cui
Article
Toxicology
Eva Gijbels, Vania Vilas-Boas, Pieter Annaert, Tamara Vanhaecke, Lindsey Devisscher, Mathieu Vinken
ARCHIVES OF TOXICOLOGY
(2020)
Article
Toxicology
Shuo Yang, Matthias Diem, Jakob D. H. Liu, Sebastiaan Wesseling, Jacques Vervoort, Chris Oostenbrink, Ivonne M. C. M. Rietjens
ARCHIVES OF TOXICOLOGY
(2020)
Article
Toxicology
Dongying Li, Leihong Wu, Bridgett Knox, Si Chen, William H. Tolleson, Fang Liu, Dianke Yu, Lei Guo, Weida Tong, Baitang Ning
ARCHIVES OF TOXICOLOGY
(2020)
Article
Medicine, General & Internal
Suofeng Sun, Yuan Li, Bowei Liu, Bingyong Zhang, Shuangyin Han, Xiuling Li
ARCHIVES OF MEDICAL SCIENCE
(2020)
Article
Biology
Albert Braeuning, Almut Mentz, Felix F. Schmidt, Stefan P. Albaum, Hannes Planatscher, Joern Kalinowski, Thomas O. Joos, Oliver Poetz, Dajana Lichtenstein