Review
Oncology
Xiaofeng Duan, Stephen Iwanowycz, Soo Ngoi, Megan Hill, Qiang Zhao, Bei Liu
Summary: GRP94 plays a crucial role in tumor development by promoting survival signals, modulating immune responses, and correlating with aggressive phenotypes and poor clinical outcomes. It has the potential to be a therapeutic target in malignancies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beibei Fu, Xiaoyuan Lin, Shun Tan, Rui Zhang, Weiwei Xue, Haiwei Zhang, Shanfu Zhang, Qingting Zhao, Yu Wang, Kelly Feldman, Lei Shi, Shaolin Zhang, Weiqi Nian, Krishna Chaitanya Pavani, Zhifeng Li, Xingsheng Wang, Haibo Wu
Summary: The research reveals that the miR-342-3p/SOCS6 axis plays a crucial role in regulating anti-Mtb immunity and the balance between cell apoptosis and necrosis during Mtb infection, providing new insights for developing host-directed therapies targeting these pathways.
Article
Medicine, Research & Experimental
Qihang Li, Zhiyu Zhang, HongChao Jiang, Jun Hou, Yuhang Chai, Hongxing Nan, Feng Li, Lianghai Wang
Summary: DLEU1 is highly expressed in ESCC tissues and its upregulation is associated with worse prognosis. DLEU1 promotes tumor growth by inhibiting cell apoptosis and stabilizes DYNLL1 by interfering with RNF114-mediated ubiquitination and proteasomal degradation. Additionally, DLEU1 upregulation may be facilitated by promoter hypomethylation. Targeting DLEU1 may enhance sensitivity of ESCC cells to cisplatin-induced death.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao, Jiansong Ji
Summary: The study found that USP9X alleviates the malignant potential of cholangiocarcinoma through upregulation of EGLN3. These findings provide a novel insight into the potential of USP9X as a biomarker or therapeutic/diagnostic target for cholangiocarcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Oncology
Tingzheng Pan, Xuetao Li, Yanyan Li, Zhennan Tao, Hui Yao, Yue Wu, Guangliang Chen, Kai Zhang, Youxin Zhou, Yulun Huang
Summary: Inhibition of USP7 has been shown to induce apoptosis in GBM cells, with the key anti-apoptotic substrate of USP7 identified as ARF4. Experimental evidence confirmed the direct interaction of USP7 with ARF4, as well as the suppression of tumor growth and promotion of apoptotic gene expression upon USP7 inhibition in vivo. This suggests that targeted inhibition of USP7 may be an effective approach for the treatment of GBM, highlighting the potential clinical significance of novel specific inhibitors such as P5091.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Stephen Iwanowycz, Soo Ngoi, Yingqi Li, Megan Hill, Christopher Koivisto, Melodie Parrish, Beichu Guo, Zihai Li, Bei Liu
Summary: DC2s, the majority of conventional DCs within most tumors, have the potential to initiate and sustain antitumor immunity, showing significant correlation with survival across multiple human cancers. Impairment of DC1s and enhancement of DC2 functionality leads to improved tumor control, highlighting the therapeutic and prognostic potential of DC2s within checkpoint blockade-resistant tumors.
Article
Ophthalmology
Tiantian Qi, Ruihua Jing, Bo Ma, Conghui Hu, Chan Wen, Yongping Shao, Cheng Pei
Summary: This study reveals that the downregulation of RNF157 contributes to age-related cataract by upregulating p53, suggesting that modulation of RNF157 expression may serve as a potential therapeutic strategy for cataracts.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Anqi Wang, Jiayu Liu, Yuhan Yang, Zhejie Chen, Caifang Gao, Zhanguo Wang, Chaomei Fu, Liang Zou, Shengpeng Wang
Summary: In this study, it was found that Shikonin could induce necrosis and apoptosis in MDA-MB-231 cells by promoting autoubiquitination and degradation of cellular inhibitor of apoptosis proteins 1 and 2. This led to decreased ubiquitination of RIP1, inhibiting pro-survival signaling pathways and accelerating cell necrosis. The mechanisms of Shikonin-induced necrosis and apoptosis presented in this study provide insight for potential therapeutic approaches in triple negative breast cancer.
Article
Plant Sciences
Yuxing Mo, Bian Jiang, Jingxin Huo, Jiayi Lu, Xiaoyue Zeng, Yan Zhou, Tao Zhang, Min Yang, Yuerong Wei, Kaidong Liu
Summary: The study identified lysine ubiquitination sites on diverse proteins in papaya, revealing the essential role of lysine ubiquitination in the fruit ripening process.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Oncology
Xiao-Yu Wang, Hai-Wei Mao, Xiao-Hui Guan, Qi-Ming Huang, Zhen-Ping Yu, Jie Wu, Hui-Lan Tan, Feng Zhang, Xuan Huang, Ke-Yu Deng, Hong-Bo Xin
Summary: TRIM65 knockdown promotes cervical cancer cell death through enhancing autophagy and apoptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dacai Xu, Jiawen Wu, Liang Dong, Wenwen Luo, Lanying Li, Daolin Tang, Jinbao Liu
Summary: Serpinc1 plays an unexpected role in suppressing hepatocellular carcinoma, with its high expression associated with better prognosis and improved tumor immune microenvironment. It inhibits HCC cell growth by inducing apoptosis and also suppresses the formation of tumor-promoting M2 macrophages.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Killian Chaumonnot, Sophie Masson, Hugo Sikner, Alexanne Bouchard, Valentin Baverel, Pierre-Simon Bellaye, Bertrand Collin, Carmen Garrido, Evelyne Kohli
Summary: GRP94, an ER stress protein with dual inflammatory functions, is co-secreted with C3 under ER stress conditions in macrophages, contributing to the pro-inflammatory profile observed in stressed cells.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Surinder M. Soond, Lyudmila V. Savvateeva, Vladimir A. Makarov, Neonila V. Gorokhovets, Paul A. Townsend, Andrey A. Zamyatnin
Summary: The study highlights the up-regulation of cathepsin S expression under Paclitaxel-stimulatory conditions and its ability to cleave the apoptotic p21 BAX protein. It also demonstrates the potential therapeutic use of CS-PEP1 as an anti-cancer agent against chemotherapeutic-resistant Renal Clear Cell Carcinoma kidney cancer cells.
Review
Cell Biology
Zhijun Liu, Francis Ka-Ming Chan
Summary: RIP kinases, including RIPK1 and RIPK3, are key adaptors in inflammatory and cell death signaling pathways. Their activities are tightly regulated by post-translational modifications and environmental factors, which are crucial for proper immune responses and tissue homeostasis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Transplantation
Liang Peng, Di Liu, Haiyang Liu, Ming Xia, Lili Wan, Mei Li, Junyong Zhao, Chengyuan Tang, Guochun Chen, Xiangpin Qu, Zheng Dong, Hong Liu
Summary: BRAP plays an important role in cisplatin-induced acute kidney injury (AKI) by regulating tubular cell apoptosis and necroptosis. BRAP downregulation is associated with decreased expression of SIRT2. The findings suggest that BRAP may be a potential therapeutic target for AKI.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Oncology
Junwei Hou, Mengmeng Deng, Xin Li, Weiwei Liu, Xiaoyu Chu, Jing Wang, Feng Chen, Songdong Meng
Article
Multidisciplinary Sciences
Jun Hu, Yaxing Xu, Changfei Li, Junli Hao, Shanxin Peng, Xiaoyu Chu, Dake Zhang, Dongping Xu, Songdong Meng
SCIENTIFIC REPORTS
(2015)
Article
Pharmacology & Pharmacy
Xiaoyu Chu, Bo Wu, Hongxia Fan, Junwei Hou, Junli Hao, Jun Hu, Baozhong Wang, Guangze Liu, Changfei Li, Songdong Meng
ANTIVIRAL RESEARCH
(2016)
Article
Virology
Ningning Liu, Jinfang Zhang, Xiaohai Yang, Tong Jiao, Xin Zhao, Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li, Xin Ye
JOURNAL OF VIROLOGY
(2017)
Article
Gastroenterology & Hepatology
Ningning Liu, Qi Liu, Xiaohai Yang, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, Xin Ye
Article
Virology
Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, Xin Ye
JOURNAL OF VIROLOGY
(2015)
Article
Multidisciplinary Sciences
Jiming Gao, Shuqi Xiao, Yihong Xiao, Xiangpeng Wang, Chong Zhang, Qin Zhao, Yuchen Nan, Baicheng Huang, Hongliang Liu, Ningning Liu, Junhua Lv, Taofeng Du, Yani Sun, Yang Mu, Gang Wang, Shahid Faraz Syed, Gaiping Zhang, Julian A. Hiscox, Ian Goodfellow, En-Min Zhou
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Qi Liu, Ningning Liu, Qilin Shangguan, Fang Zhang, Wenjia Chai, Xiaomei Tong, Xin Zhao, Zhiwei Li, Dandan Qi, Xin Ye
SCIENTIFIC REPORTS
(2019)
Article
Gastroenterology & Hepatology
Ningning Liu, Ching Wen Chang, Clifford J. Steer, Xin Wei Wang, Guisheng Song
Summary: The study reveals that microRNA-15a/16-1 attenuates immunosuppression in hepatocellular carcinoma by disrupting CCL22-mediated communication between KCs and Tregs. MicroRNA-15a/16-1 represents a potential immunotherapy against HCC.
Article
Gastroenterology & Hepatology
Ningning Liu, Xiaomei Wang, Clifford John Steer, Guisheng Song
Summary: The study revealed that M2 polarisation of Kupffer cells is a major contributor to hepatocellular carcinoma in AKT/Ras mice, while microRNA-206 prevents HCC by promoting M1 polarisation of Kupffer cells and enhancing recruitment of CD8(+) T cells, suggesting its potential use as an immunotherapeutic approach.
Article
Gastroenterology & Hepatology
Ningning Liu, Clifford J. Steer, Guisheng Song
Summary: This study revealed that c-Myc-educated hepatocytes promote immunosuppression by overproducing TGF beta 1, while miR-206 attenuates TGF beta 1 overproduction, disrupting the communication between malignant hepatocytes and CTLs/Tregs, thus preventing HCC development. miR-206 represents a potential immunotherapeutic agent against HCC.
Article
Biochemistry & Molecular Biology
Ningning Liu, Tianpeng Zhang, Clifford J. Steer, Guisheng Song
Summary: miR-378a prevents colorectal cancer by inhibiting polyamine synthesis, suggesting its potential as a therapeutic agent against CRC.
CELL AND BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Tianpeng Zhang, Hongtao Shi, Ningning Liu, Jing Tian, Xiaoling Zhao, Clifford J. Steer, Qinghua Han, Guisheng Song
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.