Article
Nanoscience & Nanotechnology
Jungho Kim, Se-Jin Park, Jisang Park, Hojeong Shin, Yong-Suk Jang, Jae-Sung Woo, Dal-Hee Min
Summary: Dengue virus causes infectious diseases, but there are no approved antiviral drugs. Developing antiviral agents targeting viral enzymes, such as helicase, is important. Helicase inhibition could serve as a direct-acting antiviral agent.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Gastroenterology & Hepatology
Maria M. Zanone, Claudia Marinucci, Alessia Ciancio, Dario Cocito, Federica Zardo, Emanuela Spagone, Bruno Ferrero, Cristina Cerruti, Lorena Charrier, Franco Cavallo, Giorgio M. Saracco, Massimo Porta
Summary: This longitudinal study assessed the prevalence and outcome of neuropathy in chronic HCV patients before and after DAA treatment. Results showed improvement in neuropathy after DAA therapy, supporting the need for larger intervention studies.
LIVER INTERNATIONAL
(2021)
Review
Virology
Mohammad Enamul Hoque Kayesh, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara
Summary: The tree shrew model plays a significant role in understanding human viral infection and pathogenesis, highlighting its potential as a viable viral infection model. Researchers have summarized the latest progress of the tree shrew model in this area.
Article
Multidisciplinary Sciences
Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki, Yohei Watanabe
Summary: Patients with severe COVID-19 exhibit elevated levels of cytokines and delayed interferon response. The study finds that SARS-CoV-2 generates excessive small viral RNAs encoding the 50 ends of positive-sense genes, which can stimulate the immune response. It suggests that RIG-I activation by accumulated SARS-CoV-2 50 end svRNAs may contribute to over-exuberant IFN production and the weaker immune response in less pathogenic coronaviruses may be due to lower svRNA production during replication.
Review
Immunology
Gilberto Betancor
Summary: MX proteins play a crucial role in the immune response to viral infections. This review focuses on MX2 and its antiviral activity against HIV-1, as well as other RNA and DNA viruses. The molecular determinants governing MX2's antiviral activity are discussed, with potential areas for further research highlighted.
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Review
Immunology
Coen Govers, Philip C. Calder, Huub F. J. Savelkoul, Ruud Albers, R. J. Joost van Neerven
Summary: Respiratory infections, especially in vulnerable groups, place a heavy burden on the health care system. Nutrition plays a role in optimizing immune responsiveness and preventing infections. Micronutrients act as regulators of immune cells' molecular responses, while undernutrition and specific micronutrient deficiencies impair immune response and increase susceptibility to respiratory and gastrointestinal infections. Dietary components such as proteins, pre-, pro- and synbiotics, as well as animal- and plant-derived bioactive components, can support the immune system. Both innate and adaptive defense systems contribute to respiratory tract immunity, and this review aims to describe the effects of different dietary components on these immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Meritxell Llorens-Revull, Maria Isabel Costafreda, Angie Rico, Mercedes Guerrero-Murillo, Maria Eugenia Soria, Sofia Piriz-Ruzo, Elena Vargas-Accarino, Pablo Gabriel-Medina, Francisco Rodriguez-Frias, Mar Riveiro-Barciela, Celia Perales, Josep Quer, Silvia Sauleda, Juan Ignacio Esteban, Marta Bes
Summary: The study revealed that DAA treatment can partly reverse the exhaustion of CD4+ specific T cells in chronically infected HCV patients, while the proliferative capacity of both HCV-specific CD4+ and CD8+ T cells can be restored after DAA therapies.
Article
Biochemistry & Molecular Biology
Dong-Eun Kim, Young Hyun Shin, Jung-Eun Cho, Subeen Myung, Hong Gi Kim, Kyung-Chang Kim, Chul Min Park, Cheol-Hee Yoon
Summary: This study synthesized a series of novel 3-oxindole-2-carboxylates and evaluated their antiviral activity against HIV-1 infection. One compound showed the most potent inhibitory effect without severe cytotoxicity. Mode-of-action studies indicated that these compounds specifically inhibited Tat-mediated viral transcription.
Review
Immunology
Barbara N. Porto
Summary: The virome refers to the viral component of the microbiome, including all viruses that inhabit the human body. Despite previous limitations in accurately characterizing viruses, recent advancements in methods such as deep sequencing and metagenomics have allowed for a better understanding of the diverse viral species present in the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yifei Duan, Jinlan He, Yali Cui, Wensheng Li, Yongmei Jiang
Summary: In west China, respiratory viruses influenza A and respiratory syncytial virus (RSV) were found to be the most common among young children with acute respiratory tract infection, showing pronounced seasonality. During the SARS-CoV-2 pandemic, isolation measures led to a decline in the number of ARTI cases.
Review
Biochemistry & Molecular Biology
Luyao Wang, Zhiqiang Xia, Wei Tang, Yu Sun, Yingliang Wu, Hang Fai Kwok, Fang Sun, Zhijian Cao
Summary: Understanding the molecular and cellular mechanisms of viral infections is crucial for preventing and treating viral diseases. The p38 MAPK signaling pathway plays an important role in viral infections, and studying its activation can provide insights for developing antiviral strategies.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Muhammad Nauman Zahid
Summary: There is concern about using organs from HCV-positive donors for transplantation. However, direct-acting antiviral drugs have been proven to effectively treat Hepatitis C in transplant patients. This review will examine the impact of DAA treatments on transplants of different organs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Ebony A. Monson, Alice M. Trenerry, Jay L. Laws, Jason M. Mackenzie, Karla J. Helbig
Summary: Lipid droplets play crucial roles in cellular physiology and pathophysiology, regulating lipid storage, protein sequestration, and serving as hubs for integrating metabolic and inflammatory processes in response to cellular stress.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna A. Shtro, Artem M. Klabukov, Anzhelika V. Garshinina, Anastasia V. Galochkina, Yulia V. Nikolaeva, Tatyana M. Khomenko, Danila E. Bobkov, Aleksey A. Lozhkov, Konstantin V. Sivak, Kirill S. Yakovlev, Andrey B. Komissarov, Sophia S. Borisevich, Konstantin P. Volcho, Nariman F. Salakhutdinov
Summary: This article discusses the mechanism of action of compound K142 against respiratory syncytial virus (RSV), showing that its interaction with RSV surface proteins is crucial for its antiviral activity. However, in vivo studies have indicated weak antiviral activity, suggesting the need for further modifications to enhance its efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Paul C. Jordan, Sarah K. Stevens, Yuen Tam, Ryan P. Pemberton, Shuvam Chaudhuri, Antitsa D. Stoycheva, Natalia Dyatkina, Guangyi Wang, Julian A. Symons, Jerome Deval, Leo Beigelman
ACS CHEMICAL BIOLOGY
(2017)
Article
Rheumatology
Yana Zhang, Ming Gui, Yajun Wang, Nikita Mani, Shuvam Chaudhuri, Beixue Gao, Huabin Li, Yashpal S. Kanwar, Sarah A. Lewis, Sabrina N. Dumas, James M. Ntambi, Kezhong Zhang, Deyu Fang
Summary: The study uncovers a molecular link in the dysregulation of lipid metabolism in the pathogenesis of lupus, demonstrating that the IRE-1 alpha/XBP-1 pathway controls plasma cell differentiation through SCD-1/SCD-2-mediated monounsaturated fatty acid synthesis. Targeting IRE-1 alpha and monounsaturated fatty acid synthesis may be a potential treatment strategy for patients with SLE.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juncheng Wei, Bryan T. Harada, Dan Lu, Ruihua Ma, Beixue Gao, Yanan Xu, Elena Montauti, Nikita Mani, Shuvam M. Chaudhuri, Shana Gregory, Samuel E. Weinberg, Donna D. Zhang, Richard Green, Chuan He, Deyu Fang
Summary: The study reveals that accumulation of unfolded/misfolded proteins selectively induces N-6-adenosine-methyltransferase-14 (METTL14) expression, which promotes C/EBP-homologous protein (CHOP) mRNA decay to inhibit pro-apoptotic gene expression. The unfolded protein response induces METTL14 expression by competing against the ER-associated degradation machinery, resulting in adaptation to proteotoxic stress.
Letter
Allergy
Wenyi Chen, Yurong Bai, Weifeng Kong, Xin Luo, Yinhui Zeng, Jingyuan Chen, Xinyue Wang, Qingwu Wu, Shuvam Chaudhuri, Jianning Chen, Qintai Yang, Yana Zhang
Summary: The crystalline CLC structures in nasal tissues may serve as an easy-counting and promising biomarker to predict CRSwNP recurrence.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Multidisciplinary Sciences
Elena Montauti, Samuel E. Weinberg, Peng Chu, Shuvam Chaudhuri, Nikita L. Mani, Radhika Iyer, Yuanzhang Zhou, Yusi Zhang, Changhong Liu, Chen Xin, Shana Gregory, Juncheng Wei, Yana Zhang, Wantao Chen, Zhaolin Sun, Ming Yan, Deyu Fang
Summary: This study reveals the mechanisms underlying T-reg cell adaptation in the tumor microenvironment. TME selectively induces two specific deubiquitinases of Foxp3 by regulating TGF-beta, HIF, and mTOR signaling to maintain Treg stability and suppressive functions. The study also identifies Usp22 as a potential therapeutic target for enhancing antitumor immunity by reducing intratumoral Treg Foxp3 expression.
Article
Oncology
Shana Gregory, Yanan Xu, Ping Xie, Jie Fan, Beixue Gao, Nikita Mani, Radhika Iyer, Amy Tang, Juncheng Wei, Shuvam Mohan Chaudhuri, Shengnan Wang, Huiping Liu, Bin Zhang, Deyu Fang
Summary: In breast cancer, USP22 functions as a positive regulator for CD73 by protecting it from proteasomal degradation, thus promoting tumor growth and metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Zhinan Jin, April Kinkade, Ishani Behera, Shuvam Chaudhuri, Kathryn Tucker, Natalia Dyatkina, Vivek K. Rajwanshi, Guangyi Wang, Andreas Jekle, David B. Smith, Leo Beigelman, Julian A. Symons, Jerome Deval
ANTIVIRAL RESEARCH
(2017)