Article
Virology
Pinar Yazici ozkaya, Ese Eda Turanli, Hamdi Metin, Ayca Aydin Uysal, Candan cicek, Bulent Karapinar
Summary: This study aimed to identify the clinical features and mortality associated with severe influenza A and B virus infections in children admitted to the pediatric intensive care unit (PICU) between 2012 and 2019. The study found that although the proportion of influenza A cases admitted to the PICU was higher, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. Additionally, there was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Raegan M. Skelton, Victor C. Huber
Summary: This article reviews the known information about the host-pathogen interactions that limit the disease caused by influenza D virus (IDV). It focuses on the early immune interactions between the virus and infected host cells in IDV pathogenesis. This work establishes a foundation for further research on IDV infection and immunity in mammalian hosts.
Article
Microbiology
Kin Kui Lai, James B. B. Munro, Guoli Shi, Saliha Majdoul, Alex A. A. Compton, Alan Rein
Summary: Serine incorporator 5 (Ser5) is a host antiviral factor against HIV-1, gammaretroviruses, and Influenza A virus (IAV). It inhibits virus-cell fusion by interacting with HA proteins and destabilizing the pre-fusion conformation of IAV HA. This study provides insights into the antiviral mechanism of Ser5.
Article
Immunology
Florian Krammer, Stacey Schultz-Cherry
Summary: Recent evidence of avian H5N1 virus transmission among mammals raises concerns about its potential for a pandemic. We need to increase awareness, preparedness, and adopt safe farming practices to prevent the emergence of concerning pathogens in the future.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Microbiology
Nicolas Malausse, Sylvie van der Werf, Nadia Naffakh, Sandie Munier
Summary: Co-infections between influenza A virus (IAV) and influenza B virus (IBV) were studied by infecting A549 cells with recombinant IAV-GFP and IBV-mCherry. Surprisingly, IBV replication was enhanced when co-infected with IAV, particularly when IAV was added 1 hour before IBV. This enhancing effect was dependent on transcription/replication of the IAV genome.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Virology
Umarqayum AbuBakar, Lina Amrani, Farah Ayuni Kamarulzaman, Saiful Anuar Karsani, Pouya Hassandarvish, Jasmine Elanie Khairat
Summary: An influenza pandemic occurs when a new influenza A virus is able to infect and transmit efficiently to a new host species. The emergence of pandemics is influenced by both viral and host factors. The interaction between the virus and the host determines the virus tropism, including binding, replication, assembly, and transmission between individuals. Avian influenza virus (AIV), which mainly infects wild birds asymptomatically, can cross into new species and occasionally achieve human-to-human transmission. This review focuses on the determinants of AIV for initiating a human pandemic and discusses the mechanisms of AIV mutation for establishing tropism and stable human adaptation. Understanding AIV tropism is crucial for preventing human transmission and improving vaccine and therapeutic agent design.
Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Editorial Material
Medicine, General & Internal
Kanta Subbarao
Summary: We have been fortunate to avoid the co-circulation of influenza and SARS-CoV-2 since 2020, but this situation is likely to change.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Review
Medicine, General & Internal
Timothy M. Uyeki, David S. Hui, Maria Zambon, David E. Wentworth, Arnold S. Monto
Summary: Seasonal influenza caused by influenza A and B viruses is a significant global burden. Vaccination is the primary prevention measure, but novel influenza viruses still pose pandemic threats.
Article
Biochemistry & Molecular Biology
Maria Auladell, Hoang Vu Mai Phuong, Le Thi Quynh Mai, Yeu-Yang Tseng, Louise Carolan, Sam Wilks, Pham Quang Thai, David Price, Nguyen Thanh Duong, Nguyen Le Khang Hang, Le Thi Thanh, Nguyen Thi Hong Thuong, Tran Thi Kieu Huong, Nguyen Thi Ngoc Diep, Vu Thi Ngoc Bich, Arseniy Khvorov, Luca Hensen, Tran Nhu Duong, Katherine Kedzierska, Dang Duc Anh, Heiman Wertheim, Scott D. Boyd, Kim L. Good-Jacobson, Derek Smith, Ian Barr, Sheena Sullivan, H. Rogier van Doorn, Annette Fox
Summary: Recent prior influenza A infection enhances antibody responses to subsequent influenza vaccination and broadens the reactivity to different strains. Immunological memory induced by prior infection plays an important role in vaccine responses.
Article
Microbiology
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Mizhou Hui, Junwei Li
Summary: A replication-deficient recombinant influenza virus was developed in this study, which stimulated robust immune response and conferred complete protection against H5N1 or H9N2 influenza virus infections in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Claudia Maria Trombetta, Otfried Kistner, Emanuele Montomoli, Simonetta Viviani, Serena Marchi
Summary: Influenza is a vaccine preventable disease and vaccination is the most effective method of controlling the morbidity and mortality of seasonal influenza, especially among risk groups. The effectiveness of current influenza vaccines is suboptimal, but they are still effective against morbidity and mortality in all age and risk groups, particularly in young children and older adults.
Editorial Material
Multidisciplinary Sciences
Younjung Kim, Guillaume Fournie, Raphalle Metras, Daesub Song, Christl A. Donnelly, Dirk U. Pfeiffer, Pierre Nouvellet
Summary: This article discusses recent outbreaks of highly pathogenic avian influenza in two cat shelters in South Korea and emphasizes the need to enhance surveillance for cross-species viral transmission from a One Health perspective.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Alvaro Lopez-Valinas, Marta Valle, Miaomiao Wang, Ayub Darji, Guillermo Cantero, Chiara Chiapponi, Joaquim Segales, Llilianne Ganges, Jose I. Nunez
Summary: Influenza A viruses have the ability to infect a wide range of bird and mammal species. They constantly evolve due to low proofreading activity and genomic reassortment, posing a threat to human and animal health. This study found that vaccination can reduce the likelihood of genomic reassortment and may influence the evolution of swine influenza viruses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan
Summary: Research suggests that avian influenza VLP vaccines expressing multiple neuraminidases can provide both homologous and heterosubtypic protection against different subtypes, offering a promising approach for developing a universal influenza A vaccine against avian and human influenza virus infections.
Letter
Immunology
Charlotte Charpentier, Ricardo Camacho, Jean Ruelle, Josef Eberle, Lutz Guertler, Alejandro Pironti, Martin Stuermer, Francoise Brun-Vezinet, Rolf Kaiser, Diane Descamps, Martin Obermeier
CLINICAL INFECTIOUS DISEASES
(2015)
Article
Biochemical Research Methods
Eddy Okoth Odari, Alex Maiyo, Raphael Lwembe, Lutz Gurtler, Josef Eberle, Hans Nitschko
JOURNAL OF VIROLOGICAL METHODS
(2015)
Article
Multidisciplinary Sciences
Stephanie Rebensburg, Markus Helfer, Martha Schneider, Herwig Koppensteiner, Josef Eberle, Michael Schindler, Lutz Guertler, Ruth Brack-Werner
SCIENTIFIC REPORTS
(2016)
Review
Immunology
Lutz G. Guertler, Josef Eberle
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2017)
Article
Public, Environmental & Occupational Health
H. F. Rabenau, R. Gottschalk, L. Guertler, A. E. Haberl, O. Hamouda, H. Himmelreich, K. Korn, T. Mertens, K. W. Schmidt, S. Schmiedel, A. Spickhoff, G. Wirz, P. Wutzler, S. Wicker
BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ
(2012)
Article
Immunology
Charlotte Charpentier, Ricardo Camacho, Jean Ruelle, Rolf Kaiser, Josef Eberle, Lutz Guertler, Alejandro Pironti, Martin Stuermer, Francoise Brun-Vezinet, Diane Descamps, Martin Obermeier
CLINICAL INFECTIOUS DISEASES
(2013)
Editorial Material
Hematology
Giovanni Di Minno, Mariana Canaro, James W. Ironside, David Navarro, Carlo Federico Perno, Andreas Tiede, Lutz Guertler
Editorial Material
Virology
Lutz Guertler
Article
Virology
Josef Eberle, Lutz Guertler
Article
Virology
Josef Eberle, Lutz Guertler
Editorial Material
Virology
Wolfram H. Gerlich, Dieter Glebe, Lutz G. Guertler, Rolf Kaiser
Article
Virology
Lutz G. Guertler
Article
Hematology
Kai Hourfar, Josef Eberle, Markus Mueller, C. Micha Nuebling, Michael Chudy, Julia Kress, Lutz Guertler, Uschi Mayr-Wohlfart, Hubert Schrezenmeier, Inke Hellmann, Juergen Luhm, Sabine Kraas, Juergen Ringwald, Knut Gubbe, Kerstin Frank, Andreas Karl, Torsten Tonn, Maike Jaeger, Walid Sireis, Erhard Seifried, Michael Schmidt
Review
Hematology
Giovanni Di Minno, David Navarro, Carlo Federico Perno, Mariana Canaro, Lutz Guertler, James W. Ironside, Hermann Eichler, Andreas Tiede
ANNALS OF HEMATOLOGY
(2017)
Article
Immunology
Aubin J. Nanfack, Desire Takou, Joseph Fokam, Romina Salpini, Maria M. Santoro, Giulia Cappelli, Martin Baane, Suzie M. Tetang, Josef Eberle, Lutz Gurtler, Francesca Ceccherini-Silberstein, Judith N. Torimiro, Vittorio Colizzi, Carlo-Federico Perno, Alexis Ndjolo
CURRENT HIV RESEARCH
(2017)
