Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
出版年份 2020 全文链接
标题
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
作者
关键词
Cytokines, Cytokine storm, Innate Immunity, PAMPs, Sepsis, TLRs
出版物
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 89, Issue -, Pages 107087
出版商
Elsevier BV
发表日期
2020-10-12
DOI
10.1016/j.intimp.2020.107087
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
- (2020) Kristina E Rudd et al. LANCET
- TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
- (2020) Salik Hussain et al. eLife
- GRP94 Regulates M1 Macrophage Polarization and Insulin Resistance
- (2020) Lili Song et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system
- (2020) Francesca Coperchini et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
- (2020) Ulf Andersson et al. MOLECULAR MEDICINE
- PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
- (2020) Sreekanth Rajan et al. Nature Chemical Biology
- LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling
- (2020) Wenbo Li et al. Frontiers in Immunology
- Protective Effect of Metformin on Sepsis Myocarditis in Zebrafish
- (2020) Mingming Zhang et al. Dose-Response
- SHP‐1 suppresses the antiviral innate immune response by targeting TRAF3
- (2020) Doudou Hao et al. FASEB JOURNAL
- SHP‐1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production
- (2020) Lin Lin et al. FEBS LETTERS
- Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
- (2020) Mihee Oh et al. Scientific Reports
- TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes
- (2020) Brittney N. Nguyen et al. PLoS Pathogens
- Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice
- (2019) Qi Li et al. Journal of Immunology Research
- Elevated serum IL-37 concentrations in patients with sepsis
- (2019) Yong-Chun Wang et al. MEDICINE
- Role of IRF4 in the Protection of Metformin-Mediated Sepsis Myocarditis
- (2019) Minghua Li et al. Dose-Response
- RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
- (2019) Snahel Patel et al. CELL DEATH AND DIFFERENTIATION
- Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
- (2019) Michael Carty et al. IMMUNITY
- TIPE2 suppresses Pseudomonas aeruginosa keratitis by inhibiting NF-κB signaling and the infiltration of inflammatory cells
- (2019) Qun Wang et al. JOURNAL OF INFECTIOUS DISEASES
- Toll-like receptors in the pathogenesis of neuroinflammation
- (2019) V. Kumar JOURNAL OF NEUROIMMUNOLOGY
- Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock
- (2019) Chenxi Li et al. Cell Death & Disease
- Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis
- (2019) Chao Cao et al. Cell Death & Disease
- Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation
- (2019) Jinchun Zhou et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling
- (2019) Dongqiang Yang et al. MOLECULAR IMMUNOLOGY
- Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species
- (2018) Glenn Hamonic et al. CELL AND TISSUE RESEARCH
- DAMP-TLR-cytokine axis dictates the fate of tumor
- (2018) Ashok Patidar et al. CYTOKINE
- Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2
- (2018) Joshua D. Bernstock et al. FASEB JOURNAL
- Small-Molecule Inhibitors Targeting Protein SUMOylation as Novel Anticancer Compounds
- (2018) Yanfang Yang et al. MOLECULAR PHARMACOLOGY
- Drugging SUMOylation for neuroprotection and oncotherapy
- (2018) JoshuaD Bernstock et al. Neural Regeneration Research
- Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis
- (2018) Theodora A.M. Claushuis et al. PLATELETS
- Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
- (2018) Jesus Cosin-Roger et al. PLoS One
- Toll-Like Receptors: Regulators of the Immune Response in the Human Gut
- (2018) Hubert Hug et al. Nutrients
- The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
- (2018) Meihong Deng et al. IMMUNITY
- The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
- (2017) Ricardo Rodríguez-Calvo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells
- (2017) Sarang Tartey et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis
- (2017) Stefanie Steiger et al. JOURNAL OF IMMUNOLOGY
- TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF–TBK1 Interaction
- (2017) Wen Ye et al. JOURNAL OF IMMUNOLOGY
- Shp1 function in myeloid cells
- (2017) Clare L. Abram et al. JOURNAL OF LEUKOCYTE BIOLOGY
- TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses
- (2017) Nicholas J. Hess et al. JOURNAL OF LEUKOCYTE BIOLOGY
- IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells
- (2017) Qiong Zhan et al. MOLECULAR MEDICINE
- Recognizing Sepsis as a Global Health Priority — A WHO Resolution
- (2017) Konrad Reinhart et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model
- (2017) Anargyros Bakopoulos et al. PLoS One
- Cytokine storm and sepsis disease pathogenesis
- (2017) Benjamin G. Chousterman et al. Seminars in Immunopathology
- Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury
- (2017) Tanaporn Panich et al. BMC Nephrology
- Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β
- (2017) Jin Hee Park et al. Scientific Reports
- Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
- (2017) Keqiang Chen et al. Journal of the American Heart Association
- Toll-Interacting Protein in Resolving and Non-Resolving Inflammation
- (2017) Elizabeth J. A. Kowalski et al. Frontiers in Immunology
- Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation
- (2017) V. Kumar European Journal of Inflammation
- Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages
- (2017) Weishan Fang et al. Scientific Reports
- MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses
- (2017) Chanyoung Shin et al. Scientific Reports
- Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming
- (2017) Joshua D. Bernstock et al. Scientific Reports
- Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection
- (2016) Lei Yue et al. AMERICAN JOURNAL OF PATHOLOGY
- The Global Epidemiology of Sepsis. Does It Matter That We Know So Little?
- (2016) Simon Finfer et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations
- (2016) Carolin Fleischmann et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
- (2016) Haitao Guo et al. Cell Host & Microbe
- Cellular and molecular regulation of innate inflammatory responses
- (2016) Juan Liu et al. Cellular & Molecular Immunology
- Suppression of innate inflammation and immunity by interleukin-37
- (2016) Charles A. Dinarello et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The immune system's role in sepsis progression, resolution, and long-term outcome
- (2016) Matthew J. Delano et al. IMMUNOLOGICAL REVIEWS
- Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis
- (2016) Yu Gong et al. INFLAMMATION
- Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression
- (2016) Ming-Wei Liu et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
- (2016) Mervyn Singer et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal
- (2016) Michitaka Oho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling
- (2016) Song Jiang et al. JOURNAL OF IMMUNOLOGY
- Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
- (2016) Xiu-Ming Li et al. Journal of Inflammation-London
- Nuclear receptor 4A (NR4A) family – orphans no more
- (2016) Stephen Safe et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
- (2016) Rajendra Karki et al. NATURE
- Autophagosome–lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
- (2016) Maria Giovanna De Leo et al. NATURE CELL BIOLOGY
- The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3
- (2016) Yilong Zhou et al. NATURE IMMUNOLOGY
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- Multiple functions of USP18
- (2016) Nadine Honke et al. Cell Death & Disease
- Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis
- (2016) Na Diao et al. Scientific Reports
- HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia
- (2016) Nabanita Das et al. Cell Reports
- Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms
- (2016) Hirotsugu Hatai et al. PLoS One
- TAM Receptor Signaling in Immune Homeostasis
- (2015) Carla V. Rothlin et al. Annual Review of Immunology
- SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
- (2015) Dan Li et al. BMC IMMUNOLOGY
- Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance
- (2015) Shiyan Yu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- HIV Infection and Severe Sepsis
- (2015) Matthew R. Gingo et al. CRITICAL CARE MEDICINE
- IL-37: A new player in immune tolerance
- (2015) Hui-min Chen et al. CYTOKINE
- USP18 lack in microglia causes destructive interferonopathy of the mouse brain
- (2015) T. Goldmann et al. EMBO JOURNAL
- Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch
- (2015) Qingcai Meng et al. JOURNAL OF CELL BIOLOGY
- A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check
- (2015) Yinling Hu JOURNAL OF CELL BIOLOGY
- Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+T Cell Expansion and Effector Function through Direct Repression of Irf4
- (2015) Heba N. Nowyhed et al. JOURNAL OF IMMUNOLOGY
- TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury
- (2015) Hongyu Zhang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
- (2015) Adrien Decque et al. NATURE IMMUNOLOGY
- IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
- (2015) Claudia A Nold-Petry et al. NATURE IMMUNOLOGY
- Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
- (2015) Iftach Shaked et al. NATURE IMMUNOLOGY
- Complement, a target for therapy in inflammatory and degenerative diseases
- (2015) B. Paul Morgan et al. NATURE REVIEWS DRUG DISCOVERY
- Interleukin-8 for Diagnosis of Neonatal Sepsis: A Meta-Analysis
- (2015) Min Zhou et al. PLoS One
- Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88
- (2015) Byung-Cheol Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
- (2015) Suzhao Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury
- (2015) Robert Kraft et al. SHOCK
- Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
- (2015) Changwon Kho et al. Nature Communications
- PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm
- (2015) Rumiko Ono et al. Scientific Reports
- USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms
- (2015) Zhifen Yang et al. Scientific Reports
- International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module
- (2014) Víctor Daniel Rosenthal et al. AMERICAN JOURNAL OF INFECTION CONTROL
- Toll-like Receptor 4 Is Essential to Preserving Cardiac Function and Survival in Low-grade Polymicrobial Sepsis
- (2014) Ming Zhang et al. ANESTHESIOLOGY
- Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes
- (2014) Chenqi Zhao et al. BIOCHEMICAL PHARMACOLOGY
- TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
- (2014) J. H. M. van der Meer et al. BLOOD
- Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
- (2014) Alain Vandewalle et al. Cell Communication and Signaling
- Immunobiology of IL-37: mechanism of action and clinical perspectives
- (2014) Shannon Quirk et al. Expert Review of Clinical Immunology
- Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis
- (2014) MING-WEI LIU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis
- (2014) Ana C.C. Redondo et al. Jornal de Pediatria
- Toll-like Receptor-mediated Down-regulation of the Deubiquitinase Cylindromatosis (CYLD) Protects Macrophages from Necroptosis in Wild-derived Mice
- (2014) Stephen A. Schworer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Innate Immunity in Sepsis Pathogenesis and Its Modulation: New Immunomodulatory Targets Revealed
- (2014) V. Kumar et al. JOURNAL OF CHEMOTHERAPY
- The Transcription Factor Nuclear Factor of Activated T Cells c3 Modulates the Function of Macrophages in Sepsis
- (2014) Ravi Ranjan et al. Journal of Innate Immunity
- The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation
- (2014) Chinnaswamy Tiruppathi et al. NATURE IMMUNOLOGY
- MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response
- (2014) Fabiane Sônego et al. PLoS One
- Human TLR10 is an anti-inflammatory pattern-recognition receptor
- (2014) Marije Oosting et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
- (2014) S. M. Y. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HSP70 mediates degradation of the p65 subunit of nuclear factor B to inhibit inflammatory signaling
- (2014) T. Tanaka et al. Science Signaling
- Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge
- (2014) P G Través et al. Cell Death & Disease
- Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
- (2014) Judith Austermann et al. Cell Reports
- Specific Phosphorylation of Histone Demethylase KDM3A Determines Target Gene Expression in Response to Heat Shock
- (2014) Mo-bin Cheng et al. PLOS BIOLOGY
- IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis
- (2014) Silvia Moretti et al. PLoS Pathogens
- ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression
- (2013) Pei-Fang Lai et al. Evidence-based Complementary and Alternative Medicine
- Innate lymphoid cells: New paradigm in immunology of inflammation
- (2013) Vijay Kumar IMMUNOLOGY LETTERS
- Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis
- (2013) Gao-hong Dong et al. INFLAMMATION
- Increased MerTK expression in circulating innate immune cells of patients with septic shock
- (2013) Caroline Guignant et al. INTENSIVE CARE MEDICINE
- A Janus role for MerTK in the outcome of septic shock
- (2013) Massimo Girardis et al. INTENSIVE CARE MEDICINE
- Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
- (2013) Steven M. Opal et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Causes, consequences, and reversal of immune system aging
- (2013) Encarnacion Montecino-Rodriguez et al. JOURNAL OF CLINICAL INVESTIGATION
- Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin
- (2013) M. Raetz et al. JOURNAL OF IMMUNOLOGY
- Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type-Specific Functions of TLR4 during Sepsis
- (2013) M. Deng et al. JOURNAL OF IMMUNOLOGY
- MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop
- (2013) K. F. MacKenzie et al. MOLECULAR AND CELLULAR BIOLOGY
- The TLR4 antagonist Eritoran protects mice from lethal influenza infection
- (2013) Kari Ann Shirey et al. NATURE
- A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages
- (2013) Q. Peng et al. Science Signaling
- Interleukin-37
- (2013) Charles A. Dinarello et al. SEMINARS IN IMMUNOLOGY
- A20 in inflammation and autoimmunity
- (2013) Leen Catrysse et al. TRENDS IN IMMUNOLOGY
- Biology of the TAM Receptors
- (2013) G. Lemke Cold Spring Harbor Perspectives in Biology
- Sepsis in AIDS patients: clinical, etiological and inflammatory characteristics
- (2013) João Manoel Silva et al. Journal of the International AIDS Society
- Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6
- (2013) Xing Liu et al. PLoS Pathogens
- Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes
- (2013) Nadine Honke et al. PLoS Pathogens
- NLRC5: a NOD-like receptor protein with many faces in immune regulation
- (2012) Yue Zhao et al. CELL RESEARCH
- NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
- (2012) Yikun Yao et al. CELL RESEARCH
- Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice
- (2012) Yanzheng Tong et al. CELL RESEARCH
- Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses
- (2012) C Mikacenic et al. GENES AND IMMUNITY
- β-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury
- (2012) Bibo Ke et al. HEPATOLOGY
- Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii
- (2012) A. Alicia Koblansky et al. IMMUNITY
- Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation
- (2012) FangFang Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TLR4-Mediated AKT Activation Is MyD88/TRIF Dependent and Critical for Induction of Oxidative Phosphorylation and Mitochondrial Transcription Factor A in Murine Macrophages
- (2012) C. P. Bauerfeld et al. JOURNAL OF IMMUNOLOGY
- Into the Eye of the Cytokine Storm
- (2012) J. R. Tisoncik et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
- (2012) Monika Schneider et al. NATURE IMMUNOLOGY
- TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis
- (2012) Angela Castoldi et al. PLoS One
- TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification
- (2012) M. Oldenburg et al. SCIENCE
- Dissecting negative regulation of Toll-like receptor signaling
- (2012) Takeshi Kondo et al. TRENDS IN IMMUNOLOGY
- Targeting of TAK1 in inflammatory disorders and cancer
- (2012) Hiroaki Sakurai TRENDS IN PHARMACOLOGICAL SCIENCES
- Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality
- (2012) Issrah Jawad et al. Journal of Global Health
- Genetic relationships betweenA20/TNFAIP3, chronic inflammation and autoimmune disease
- (2011) Lars Vereecke et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Inflammation: a role for NR4A orphan nuclear receptors?
- (2011) Jason P. McMorrow et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Antimicrobial peptides: key components of the innate immune system
- (2011) Mukesh Pasupuleti et al. CRITICAL REVIEWS IN BIOTECHNOLOGY
- Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies
- (2011) Amisha Barochia et al. Expert Opinion on Drug Metabolism & Toxicology
- NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK
- (2011) Xiaojun Xia et al. IMMUNITY
- Two Independent Mechanisms Promote Expression of an N-terminal Truncated USP18 Isoform with Higher DeISGylation Activity in the Nucleus
- (2011) Christoph Burkart et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Low-Dose Endotoxin Induces Inflammation by Selectively Removing Nuclear Receptors and Activating CCAAT/Enhancer-Binding Protein δ
- (2011) Urmila Maitra et al. JOURNAL OF IMMUNOLOGY
- IL-6 Production Is Positively Regulated by Two Distinct Src Homology Domain 2-Containing Tyrosine Phosphatase-1 (SHP-1)-Dependent CCAAT/Enhancer-Binding Protein and NF- B Pathways and an SHP-1-Independent NF- B Pathway in Lipopolysaccharide-Stimulated Bone Marrow-Derived Macrophages
- (2011) D. Rego et al. JOURNAL OF IMMUNOLOGY
- NLRC5: a newly discovered MHC class I transactivator (CITA)
- (2011) Torsten B. Meissner et al. MICROBES AND INFECTION
- Expression of tumor necrosis factor-α induced protein 8 like-2 contributes to the immunosuppressive property of CD4+CD25+ regulatory T cells in mice
- (2011) Ying-yi Luan et al. MOLECULAR IMMUNOLOGY
- Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
- (2011) Nadine Honke et al. NATURE IMMUNOLOGY
- The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
- (2011) Jae-Min Yuk et al. NATURE IMMUNOLOGY
- Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
- (2011) Stephen J Galli et al. NATURE IMMUNOLOGY
- ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
- (2011) Wolfram Hoetzenecker et al. NATURE MEDICINE
- In Silico Approach to Inhibition of Signaling Pathways of Toll-Like Receptors 2 and 4 by ST2L
- (2011) Shaherin Basith et al. PLoS One
- USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
- (2011) Véronique François-Newton et al. PLoS One
- Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination
- (2011) Q. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The TRAF-associated protein TANK facilitates cross-talk within the I B kinase family during Toll-like receptor signaling
- (2011) K. Clark et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways
- (2010) Jun Cui et al. CELL
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- A20 inhibition of NFκB and inflammation: Targeting E2:E3 ubiquitin enzyme complexes
- (2010) Noula Shembade et al. CELL CYCLE
- SARM inhibits both TRIF- and MyD88-mediated AP-1 activation
- (2010) Jun Peng et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Intracellular Toll-like Receptors
- (2010) Amanda L. Blasius et al. IMMUNITY
- Soluble ST2 plasma concentrations predict mortality in severe sepsis
- (2010) Jacobien J. Hoogerwerf et al. INTENSIVE CARE MEDICINE
- Neutrophils: Cinderella of innate immune system
- (2010) V. Kumar et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Infection Rate and Acute Organ Dysfunction Risk as Explanations for Racial Differences in Severe Sepsis
- (2010) Florian B. Mayr JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production
- (2010) Jose M. González-Navajas et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling
- (2010) Y. Guan et al. JOURNAL OF IMMUNOLOGY
- NLRC5 Limits the Activation of Inflammatory Pathways
- (2010) S. Benko et al. JOURNAL OF IMMUNOLOGY
- ST2 Negatively Regulates TLR2 Signaling, but Is Not Required for Bacterial Lipoprotein-Induced Tolerance
- (2010) J. Liu et al. JOURNAL OF IMMUNOLOGY
- NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections
- (2010) H. Kumar et al. JOURNAL OF IMMUNOLOGY
- Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase
- (2010) Delu Zhou et al. JOURNAL OF LEUKOCYTE BIOLOGY
- SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells
- (2010) Chun Zhang et al. MOLECULAR BIOLOGY REPORTS
- IL-37 is a fundamental inhibitor of innate immunity
- (2010) Marcel F Nold et al. NATURE IMMUNOLOGY
- Calming the cytokine storm
- (2010) Charlotte Harrison NATURE REVIEWS DRUG DISCOVERY
- The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
- (2010) Jaclyn R. Gareau et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes
- (2010) N. Shembade et al. SCIENCE
- Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza
- (2010) N. R. London et al. Science Translational Medicine
- Antimicrobial peptides: The ancient arm of the human immune system
- (2010) Jochen Wiesner et al. Virulence
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes
- (2009) S-C Sun CELL DEATH AND DIFFERENTIATION
- The roles of Dok family adapters in immunoreceptor signaling
- (2009) Ryuichi Mashima et al. IMMUNOLOGICAL REVIEWS
- Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo
- (2009) Charay Jennings et al. Innate Immunity
- Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6
- (2009) Shu Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
- (2009) Manuel T. Silva JOURNAL OF LEUKOCYTE BIOLOGY
- TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway
- (2009) Eva M Palsson-McDermott et al. NATURE IMMUNOLOGY
- TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
- (2009) Tatsukata Kawagoe et al. NATURE IMMUNOLOGY
- Therapeutic potential of complement modulation
- (2009) Eric Wagner et al. NATURE REVIEWS DRUG DISCOVERY
- TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
- (2009) Cecilia Garlanda et al. TRENDS IN IMMUNOLOGY
- The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
- (2009) Lars Vereecke et al. TRENDS IN IMMUNOLOGY
- The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation
- (2009) Peyman Nakhaei et al. PLoS Pathogens
- TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis
- (2008) Honghong Sun et al. CELL
- CYLD is a crucial negative regulator of innate immune response inEscherichia colipneumonia
- (2008) Jae Hyang Lim et al. CELLULAR MICROBIOLOGY
- Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling
- (2008) Annie Bibeau-Poirier et al. CYTOKINE
- A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARα to target promoters
- (2008) Nathalie Bruck et al. EMBO JOURNAL
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction
- (2008) Luke A.J. O'Neill IMMUNITY
- Makorin-2 Is a Neurogenesis Inhibitor Downstream of Phosphatidylinositol 3-Kinase/Akt (PI3K/Akt) Signal
- (2008) Pai-Hao Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-κB
- (2008) Nollaig C. Healy et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages
- (2008) Hongmei Xu et al. MOLECULAR IMMUNOLOGY
- TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation
- (2008) Mude Shi et al. NATURE IMMUNOLOGY
- The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
- (2008) Chun Kim et al. NATURE IMMUNOLOGY
- The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
- (2008) Olga Ananieva et al. NATURE IMMUNOLOGY
- Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
- (2008) Huazhang An et al. NATURE IMMUNOLOGY
- The IL-33/ST2 pathway: therapeutic target and novel biomarker
- (2008) Rahul Kakkar et al. NATURE REVIEWS DRUG DISCOVERY
- TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS
- (2008) Reinaldo Salomão et al. SHOCK
- Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif
- (2008) Issa Abu-Dayyeh et al. PLoS Neglected Tropical Diseases
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now