Article
Medicine, Research & Experimental
Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: High expression of plasma exosomal HMGB1 is associated with an adverse radiotherapy response in ESCC patients. IR-induced exosomal HMGB1 enhances the radioresistance of ESCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Huarong Chen, Weixin Liu, Yifei Wang, Dabin Liu, Liuyang Zhao, Jun Yu
Summary: SARS-CoV-2 infection significantly increased ACE2 and TMPRSS2 expression in lung epithelial cells, leading to inflammation and interferon/cytokine signaling activation. Severe COVID-19 patients showed increased neutrophil and decreased macrophage counts in lung, along with elevated cytokine expression. Mild patients exhibited normalized neutrophil and macrophage levels, with increased T and NK cell accumulation.
Article
Neurosciences
Jixiang Zhang, Jazzmine M. Junigan, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen, Peter M. Grace
Summary: The treatment with an HDAC6 inhibitor can reverse cisplatin-induced mechanical hypersensitivity by inducing tonic enkephalin-DOR signaling in peripheral sensory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih, Tian-Li Wang
Summary: The study found that ARID1A protein transcriptionally modulates DUSP4 expression by remodeling chromatin, subsequently inactivating the MAPK pathway, leading to tumor suppression. The ARID1A-DUSP4-MAPK axis may be considered for developing targeted therapies against ARID1A-mutated cancers.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Erick J. Rodriguez-Palma, Isabel Velazquez-Lagunas, Ana Belen Salinas-Abarca, Guadalupe C. Vidal-Cantu, Maria J. Escoto-Rosales, Gabriela Castaneda-Corral, Alonso Fernandez-Guasti, Vinicio Granados-Soto
Summary: Chronic stress can trigger behavioral disorders such as nociceptive hypersensitivity and anxiety, but the mechanisms behind these disorders are not fully understood. This study investigated the role of HMGB1 and TLR4 in chronic stress-induced nociceptive hypersensitivity. The results showed that chronic stress induced tactile allodynia, anxiety-like behaviors, and activation of spinal microglia. HMGB1 and TLR4 expression was increased in the dorsal root ganglion. Blocking HMGB1 and TLR4 reduced nociceptive hypersensitivity and anxiety-like behaviors induced by chronic stress. TLR4 deletion diminished chronic stress-induced tactile allodynia in both male and female mice. The findings suggest that TLR4 could be a potential target for treating nociceptive hypersensitivity associated with chronic pain.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Chunhua Wan, Tianye Gu, Junyi Ling, Yi Qin, Jiashan Luo, Lingli Sun, Lu Hua, Jianya Zhao, Shengyang Jiang
Summary: This study revealed that subchronic exposure to PFOS may worsen liver fibrosis induced by carbon tetrachloride. The exposure to PFOS led to the activation of the HMGB1/TLR4 signaling pathway, which in turn promoted liver injury and activation of hepatic stellate cells. The study also showed that PFOS exposure induced the translocation of HMGB1 from the nucleus to the cytoplasm, accompanied by calcium flux, suggesting a potential link between calcium signaling and HMGB1 release. Additionally, the study demonstrated that PFOS-exposed conditional medium of hepatocytes induced the translocation of Smad2/3 in hepatic stellate cells in a TLR4-dependent manner.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul H. A. Quax, Anne Yael Nossent
Summary: The antisense oligonucleotide 3GA-494 inhibits the progression of atherosclerotic plaques and enhances plaque stability by dampening M1 polarization and enhancing M2 polarization. This effect is partly attributed to the activation of the Wnt signaling pathway, which regulates macrophage polarization.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Immunology
Kari Ann Shirey, Jorge C. G. Blanco, Stefanie N. Vogel
Summary: Respiratory viral infections, such as influenza, can lead to severe consequences due to misalignments between circulating strains and predicted vaccine strains. In addition to traditional antiviral treatments, blocking the host's immune response may offer a more effective approach to combat these infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Artur Javmen, Jun Zou, Shreeram C. Nallar, Henryk Szmacinski, Joseph R. Lakowicz, Andrew T. Gewirtz, Vladimir Y. Toshchakov
Summary: A peptide named 5R667 was found to have the strongest inhibitory effect on TLR5 signaling and could also inhibit signaling of TLR4, TLR2, and TLR9. It selectively bound to the TIR domains of TLR adapters and formed motifs that are highly conserved in vertebrate evolution. These findings suggest that 5R667 can serve as a pan-specific TLR inhibitor.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kai Zhuang, Xiyu Jiang, Renbin Liu, Cunsi Ye, Yumei Wang, Yunhan Wang, Shijian Quan, Heqing Huang
Summary: The study demonstrated that FMN can improve diabetic renal fibrosis and oxidative stress by activating the Nrf2/ARE signaling pathway and increasing Sirt1 protein levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Chen-Ying Fan, Fang-Hua Ye, Min Peng, Jia-Jia Dong, Wen-Wen Chai, Wen-Jun Deng, Hui Zhang, Liang-Chun Yang
Summary: Pyroptosis, a newly discovered mode of programmed cell death, plays an important role in cancer development. The non-histone nuclear protein HMGB1 is closely related to tumor development and chemotherapy resistance. However, the role of endogenous HMGB1 in regulating pyroptosis in neuroblastoma is still unknown.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Wenbo Dai, Yifu He, Kai Li
Summary: AS fibroblasts exhibited enhanced osteogenic differentiation potentials, with elevated expression of SPI1. Silencing of SPI1 inhibited osteogenic differentiation, while overexpression of TLR5 reversed this inhibition via NF-κB signaling. SPI1 regulated AS progression by modulating TLR5 through NF-κB signaling.
Article
Agronomy
Wenqiang Chen, Wei Wang, Yusong Lyu, Yawen Wu, Pingliang Huang, Shikai Hu, Xiangjin Wei, Guiai Jiao, Zhonghua Sheng, Shaoqing Tang, Gaoneng Shao, Ju Luo
Summary: Pre-harvest sprouting (PHS) is a detrimental trait in cereal production, and the regulatory mechanism involves the OsVP1 and Sdr4 genes. OsVP1 mutant showed increased PHS compared to the wild type, and activated the expression of Sdr4 by binding to its promoter. Both OsVP1 and Sdr4 mutants were insensitive to exogenous ABA and utilized the ABA signaling pathway in regulating seed dormancy, shedding light on strategies to prevent PHS in rice.
Article
Cell Biology
Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R. M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Summary: This study reveals that obesity induced by a high-fat diet can lead to inflammation in AMD, which in turn triggers iron accumulation and dysfunction in RPE cells.
Article
Oncology
Juan Wang, Yan Li, Jin-Hua Zhou, Fang-Rong Shen, Xiu Shi, You-Guo Chen
Summary: The study revealed that circATRNL1 is decreased while miR-378 is increased in ovarian cancer, and circATRNL1 acts as a sponge for miR-378 to activate Smad4 signaling, suppressing angiogenesis and ovarian cancer metastasis.
MOLECULAR ONCOLOGY
(2021)
Article
Neurosciences
Suzanne M. Green-Fulgham, Jayson B. Ball, Steven F. Maier, Kenner C. Rice, Linda R. Watkins, Peter M. Grace
Summary: This series of studies examines the impact of systemically administered therapeutics on peripheral nerve injury and the suppression of voluntary wheel running. The findings suggest that morphine treatment increases running activity, while co-administration of TLR4 and P2X7 antagonists can restore running behavior to normal levels in animals with nerve injury.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Geriatrics & Gerontology
Stephanie M. Muscat, Nicholas P. Deems, Heather D'Angelo, Meagan M. Kitt, Peter M. Grace, Nathan D. Andersen, Shaelyn N. Silverman, Kenner C. Rice, Linda R. Watkins, Steven F. Maier, Ruth M. Barrientos
Summary: Postoperative cognitive dysfunction (POCD) is a collection of cognitive impairments experienced by individuals following surgery, with persistent POCD most commonly affecting older individuals. In a study on aged rats, it was found that postsurgical treatment with morphine led to long-term memory impairments through a neuroinflammatory mechanism rather than pain modulation. Central blockade of IL-1b signaling completely prevented the memory impairment in rats, suggesting a potential target for future treatment discoveries.
NEUROBIOLOGY OF AGING
(2021)
Review
Pharmacology & Pharmacy
Ayla Hoogendoorn, Thomas D. Avery, Jiahe Li, Christina Bursill, Andrew Abell, Peter M. Grace
Summary: Fumarates have shown efficacy in treating psoriasis and multiple sclerosis due to their antioxidative, immunomodulatory, and neuroprotective properties. However, their exact mechanisms of action are not fully understood, requiring further research. Consideration of administration route, dosage, treatment timing, frequency, and duration is important in optimizing their clinical application.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna
Summary: Recent studies have shown that compound 194, a small-molecule inhibitor of CRMP2 SUMOylation, selectively reduces NaV1.7 currents and reverses mechanical allodynia in various models of neuropathic pain. The efficacy of 194 in both traditional measures of pain behavior and operator-independent mechanical conflict-avoidance assay suggests its robust anti-nociception effect in alleviating mechanical allodynia associated with nerve injury.
Article
Neurosciences
Jixiang Zhang, Jazzmine M. Junigan, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen, Peter M. Grace
Summary: The treatment with an HDAC6 inhibitor can reverse cisplatin-induced mechanical hypersensitivity by inducing tonic enkephalin-DOR signaling in peripheral sensory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Meeting Abstract
Hematology
Yankai Zhang, Celeste K. Kanne, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan
Meeting Abstract
Hematology
Yankai Zhang, Celeste K. Kanne, Britney N. Hernandez, Michael J. Lacagnina, Peter M. Grace, Mark J. Burish, Vivien A. Sheehan
Article
Neurosciences
Sanam Mustafa, Juliana E. Bajic, Benjamin Barry, Samuel Evans, Kariel R. Siemens, Mark R. Hutchinson, Peter M. Grace
Summary: The transition from acute to chronic pain is a major challenge in pain management, and the immune system plays a crucial role in this process. Understanding the dynamic and adaptable characteristics of the immune system is essential for developing new strategies to manage and treat chronic pain.
Meeting Abstract
Clinical Neurology
Mohd Sami Ur Rasheed, Fisher R. Cherry, Peter M. Grace
Meeting Abstract
Clinical Neurology
Rafael Cazuza, Michael J. Lacagnina, Peter M. Grace
Meeting Abstract
Clinical Neurology
Fisher Cherry, Mohd Sami Ur Rasheed, Melissa V. Chavez, Jiahe Li, Peter M. Grace
Meeting Abstract
Clinical Neurology
Michael J. Lacagnina, Kendal Willcox, Jiahe Li, Andrew G. Alfaro, Sabina Lorca, Peter M. Grace
Meeting Abstract
Clinical Neurology
Jiahe Li, Thomas D. Avery, Dion J. L. Turner, Fisher R. Cherry, Mohd S. Ur Rasheed, Clarissa Aguilar, Andrew J. Shepherd, Jingxian Yu, Andrew D. Abell, Peter M. Grace
Review
Neurosciences
Michael J. Lacagnina, Cobi J. Heijnen, Linda R. Watkins, Peter M. Grace
Summary: Chronic pain, a debilitating condition poorly managed by current therapeutics, involves reciprocal interactions between the nervous and immune systems. Autoimmune mechanisms, such as the production of autoantibodies by B cells, can contribute to peripheral and central sensitization, leading to persistent pain. Autoantibodies can modulate neuronal excitability by activating the complement pathway, signaling at sensory neurons, or disrupting ion channels, suggesting therapeutic implications for designing novel treatments for chronic pain.
Article
Neurosciences
Juan P. Cata, Miguel Patino, Michael J. Lacagnina, Jiahe Li, Aysegul Gorur, Ruben Agudelo-Jimenez, Bo Wei, Carin A. Hagberg, Patrick M. Dougherty, Imad Shureiqi, Peiying Yang, Peter M. Grace
Summary: A novel rat model was developed to mimic surgical recovery in humans, showing a significant reduction in recovery scores postoperatively. Nutraceutical intervention with aspirin and eicosapentaenoic acid improved recovery scores and modulated the inflammatory response after surgery.