The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
出版年份 2017 全文链接
标题
The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
作者
关键词
-
出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 21, Issue 3, Pages 291-304
出版商
Informa UK Limited
发表日期
2017-01-06
DOI
10.1080/14728222.2017.1279146
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
- (2016) Xiu-Ming Li et al. Journal of Inflammation-London
- NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration
- (2016) Erik Hedrick et al. MOLECULAR AND CELLULAR BIOLOGY
- Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis
- (2015) Takeshi Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nuclear Receptor Nr4a2 Promotes Alternative Polarization of Macrophages and Confers Protection in Sepsis
- (2015) Sahil Mahajan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells
- (2015) Daniel Crean et al. JOURNAL OF IMMUNOLOGY
- Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
- (2015) Joseph M McCoy et al. Journal of Inflammation-London
- NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation
- (2015) Olivier Calvayrac et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation
- (2015) Guijun Yan et al. MOLECULAR AND CELLULAR BIOLOGY
- Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
- (2015) Li Li et al. Nature Chemical Biology
- A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro
- (2015) Sean L. Hammond et al. NEUROSCIENCE LETTERS
- NR4A receptors up-regulate the antiproteinase alpha-2 macroglobulin (A2M) and modulate MMP-2 and MMP-9 in vascular smooth muscle cells
- (2015) Ricardo Rodríguez-Calvo et al. THROMBOSIS AND HAEMOSTASIS
- The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3
- (2015) Heba N. Nowyhed et al. Scientific Reports
- Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis
- (2015) Pengguo Chen et al. PeerJ
- NR4A nuclear receptors are orphans but not lonesome
- (2014) Kondababu Kurakula et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium
- (2014) Ingo Hilgendorf et al. CIRCULATION RESEARCH
- B-Cell Translocation Gene 2 Regulates Hepatic Glucose Homeostasis via Induction of Orphan Nuclear Receptor Nur77 in Diabetic Mouse Model
- (2014) Yong Deuk Kim et al. DIABETES
- The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells
- (2014) N. Ipseiz et al. JOURNAL OF IMMUNOLOGY
- The NR4A orphan nuclear receptors: mediators in metabolism and diseases
- (2014) Harmit S. Ranhotra JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells
- (2014) Syng-Ook Lee et al. MOLECULAR CANCER RESEARCH
- Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells
- (2014) Syng-Ook Lee et al. MOLECULAR ENDOCRINOLOGY
- Nur77 Decreases Atherosclerosis Progression in apoE−/− Mice Fed a High-Fat/High-Cholesterol Diet
- (2014) Yan-Wei Hu et al. PLoS One
- Novel Para-Phenyl Substituted Diindolylmethanes Protect Against MPTP Neurotoxicity and Suppress Glial Activation in a Mouse Model of Parkinson’s Disease
- (2014) Briana R. De Miranda et al. TOXICOLOGICAL SCIENCES
- NR4A nuclear receptors in immunity and atherosclerosis
- (2013) Anouk A.J. Hamers et al. CURRENT OPINION IN LIPIDOLOGY
- Haloperidol-induced striatalNur77expression in a non-human primate model of tardive dyskinesia
- (2013) Souha Mahmoudi et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Over-expression of Neuron-derived Orphan Receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury
- (2013) R. Rodriguez-Calvo et al. HUMAN MOLECULAR GENETICS
- Perturbation of Transcription FactorNur77Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
- (2013) Matthew P. Mount et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NR4A1 enhances neural survival following oxygen and glucose deprivation: An in vitro study
- (2013) Guodong Xiao et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Minireview: Role Of Orphan Nuclear Receptors in Cancer and Potential as Drug Targets
- (2013) Stephen Safe et al. MOLECULAR ENDOCRINOLOGY
- Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
- (2013) Wei-jia Wang et al. Nature Chemical Biology
- Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
- (2013) Takashi Sekiya et al. NATURE IMMUNOLOGY
- Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling
- (2013) Ben J. E. Raveney et al. PLoS One
- Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription
- (2012) Kimberlee S. Mix et al. ARTHRITIS AND RHEUMATISM
- NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors
- (2012) Joshua D. Hawk et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory
- (2012) S. E. McNulty et al. LEARNING & MEMORY
- NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61
- (2012) X. Zhang et al. PLACENTA
- Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
- (2012) M. S. Fassett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of NR4A transcription factors in memory formation
- (2011) Josh D. Hawk et al. BRAIN RESEARCH BULLETIN
- Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis
- (2011) Anouk A.J. Hamers et al. CIRCULATION RESEARCH
- NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis
- (2011) Richard N. Hanna et al. CIRCULATION RESEARCH
- Differential expression of oxidored nitro domain containing protein 1 (NOR1), in mouse tissues and in normal and cancerous human tissues
- (2011) Bo Xiang et al. GENE
- NR4A Gene Expression Is Dynamically Regulated in the Ventral Tegmental Area Dopamine Neurons and Is Related to Expression of Dopamine Neurotransmission Genes
- (2011) Jeffrey B. Eells et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes
- (2011) Richard N Hanna et al. NATURE IMMUNOLOGY
- The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
- (2011) S-O Lee et al. ONCOGENE
- α-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization
- (2010) Han-Jong Kim et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Nuclear orphan receptor Nor-1 contributes to depressive behavior in the Wistar–Kyoto rat model of depression
- (2010) Daniel J. Schaffer et al. BRAIN RESEARCH
- Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth
- (2010) S.-O. Lee et al. CANCER RESEARCH
- A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro
- (2010) Jing-jing Liu et al. CANCER RESEARCH
- Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels
- (2010) Peter I. Bonta et al. CARDIOVASCULAR RESEARCH
- Nuclear Receptor Nurr1 Is Expressed In and Is Associated With Human Restenosis and Inhibits Vascular Lesion Formation In Mice Involving Inhibition of Smooth Muscle Cell Proliferation and Inflammation
- (2010) Peter I. Bonta et al. CIRCULATION
- Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis
- (2010) Yue Zhao et al. CIRCULATION RESEARCH
- Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder
- (2010) G. Novak et al. GENES BRAIN AND BEHAVIOR
- Nuclear receptor Nur77 suppresses inflammatory response dependent on COX-2 in macrophages induced by oxLDL
- (2010) Qin Shao et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease
- (2010) Michael A. Pearen et al. MOLECULAR ENDOCRINOLOGY
- NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection
- (2010) N. Volakakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77
- (2009) C. Ferlini et al. CANCER RESEARCH
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- Deficiency of the NR4A Neuron-Derived Orphan Receptor-1 Attenuates Neointima Formation After Vascular Injury
- (2009) Takashi Nomiyama et al. CIRCULATION
- The Orphan Nuclear Receptor Nur77 Suppresses Endothelial Cell Activation Through Induction of IκBα Expression
- (2009) Bei You et al. CIRCULATION RESEARCH
- Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77
- (2009) Lily C. Chao et al. DIABETES
- Crosstalk in Inflammation: The Interplay of Glucocorticoid Receptor-Based Mechanisms and Kinases and Phosphatases
- (2009) Ilse M. E. Beck et al. ENDOCRINE REVIEWS
- The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress
- (2009) Luke A. J. O'Neill IMMUNOLOGICAL REVIEWS
- Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis
- (2009) Carol M. Aherne et al. MOLECULAR IMMUNOLOGY
- Involvement of linear polyubiquitylation of NEMO in NF-κB activation
- (2009) Fuminori Tokunaga et al. NATURE CELL BIOLOGY
- Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid
- (2009) Souha Mahmoudi et al. NEUROBIOLOGY OF DISEASE
- The NF- B Family of Transcription Factors and Its Regulation
- (2009) A. Oeckinghaus et al. Cold Spring Harbor Perspectives in Biology
- A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer
- (2008) Siva Kumar Kolluri et al. CANCER CELL
- Shared Principles in NF-κB Signaling
- (2008) Matthew S. Hayden et al. CELL
- TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme
- (2008) L. Verstrepen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Nuclear Factor- B Induction by Visfatin in Human Vascular Endothelial Cells: Its role in MMP-2/9 production and activation
- (2008) R. Adya et al. DIABETES CARE
- Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77
- (2008) Yongjuan Zhao et al. FEBS Journal
- Whole-genome microarray analysis identifies up-regulation of Nr4a nuclear receptors in muscle and liver from diet-restricted rats
- (2008) Radu C. Oita et al. MECHANISMS OF AGEING AND DEVELOPMENT
- 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth
- (2008) T. Inamoto et al. MOLECULAR CANCER THERAPEUTICS
- Cytosporone B is an agonist for nuclear orphan receptor Nur77
- (2008) Yanyan Zhan et al. Nature Chemical Biology
- Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
- (2008) Y. Doi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Expression of the Orphan Nuclear Receptor NURR1 in Psoriasis and Modulation following TNF-α Inhibition
- (2007) Marina O'Kane et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells
- (2007) Ronald B. Tjalkens et al. JOURNAL OF NEUROSCIENCE RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started