Into the Eye of the Cytokine Storm

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Early Corticosteroids in Severe Influenza A/H1N1 Pneumonia and Acute Respiratory Distress Syndrome

(2011) Christian Brun-Buisson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

(2011) Jason E McDermott et al.   BMC Systems Biology

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Chemokines as targets for therapy

(2011) Alexandre Garin et al.   EXPERIMENTAL CELL RESEARCH

Chemokines in health and disease

(2011) Dayanidhi Raman et al.   EXPERIMENTAL CELL RESEARCH

Genetic analysis of complex traits in the emerging Collaborative Cross

(2011) David L. Aylor et al.   GENOME RESEARCH

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Mini-review series: focus on chemokines

(2011) Iain Comerford et al.   IMMUNOLOGY AND CELL BIOLOGY

Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia

(2011) Diego Viasus et al.   JOURNAL OF INFECTION

2009 Pandemic H1N1 Influenza Virus Causes Disease and Upregulation of Genes Related to Inflammatory and Immune Responses, Cell Death, and Lipid Metabolism in Pigs

(2011) W. Ma et al.   JOURNAL OF VIROLOGY

Host Regulatory Network Response to Infection with Highly Pathogenic H5N1 Avian Influenza Virus

(2011) C. Li et al.   JOURNAL OF VIROLOGY

Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial

(2011) Sabine CA Meijvis et al.   LANCET

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load

(2011) A. C. M. Boon et al.   mBio

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

(2010) Lei Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Host response to influenza virus: protection versus immunopathology

(2010) JSM Peiris et al.   CURRENT OPINION IN IMMUNOLOGY

Timing of CD8+ T Cell Responses in Relation to Commencement of Capillary Leakage in Children with Dengue

(2010) N. T. P. Dung et al.   JOURNAL OF IMMUNOLOGY

CCR2-Antagonist Prophylaxis Reduces Pulmonary Immune Pathology and Markedly Improves Survival during Influenza Infection

(2010) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Mice Lacking Both TNF and IL‐1 Receptors Exhibit Reduced Lung Inflammation and Delay in Onset of Death following Infection with a Highly Virulent H5N1 Virus

(2010) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

(2010) C. Cilloniz et al.   JOURNAL OF VIROLOGY

The Early Whole-Blood Transcriptional Signature of Dengue Virus and Features Associated with Progression to Dengue Shock Syndrome in Vietnamese Children and Young Adults

(2010) L. T. Hoang et al.   JOURNAL OF VIROLOGY

Genomic Profiling of Tumor Necrosis Factor Alpha (TNF- ) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-  Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection

(2010) S. E. Belisle et al.   JOURNAL OF VIROLOGY

Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection

(2010) G. A. Zornetzer et al.   JOURNAL OF VIROLOGY

Pandemic Swine-Origin H1N1 Influenza A Virus Isolates Show Heterogeneous Virulence in Macaques

(2010) D. Safronetz et al.   JOURNAL OF VIROLOGY

Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway

(2010) I.-Y. Chen et al.   JOURNAL OF VIROLOGY

Structured regulation of inflammation during respiratory viral infection

(2010) Tracy Hussell et al.   LANCET INFECTIOUS DISEASES

Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection

(2010) Rudi Alberts et al.   MICROBES AND INFECTION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

IL-1 family nomenclature

(2010) Charles Dinarello et al.   NATURE IMMUNOLOGY

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

CISHand Susceptibility to Infectious Diseases

(2010) Chiea C. Khor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice

(2010) Michelle A. Carey et al.   PLoS One

PPAR-γ Activation As an Anti-inflammatory Therapy for Respiratory Virus Infections

(2010) Josep Bassaganya-Riera et al.   VIRAL IMMUNOLOGY

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

(2010) Ali Danesh et al.   VIROLOGY

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

(2010) Matthew B. Frieman et al.   PLoS Pathogens

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Interferons and viral infections

(2009) Volker Fensterl et al.   BIOFACTORS

Critical Role of IL-17RA in Immunopathology of Influenza Infection

(2009) C. R. Crowe et al.   JOURNAL OF IMMUNOLOGY

Patterns of Gene Transcript Abundance in the Blood of Children with Severe or Uncomplicated Dengue Highlight Differences in Disease Evolution and Host Response to Dengue Virus Infection

(2009) Hoang Truong Long et al.   JOURNAL OF INFECTIOUS DISEASES

Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo

(2009) Aniuska Becerra et al.   JOURNAL OF MEDICAL VIROLOGY

Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus

(2009) H. M. Weingartl et al.   JOURNAL OF VIROLOGY

Pandemic H1N1 2009 Influenza A Virus Induces Weak Cytokine Responses in Human Macrophages and Dendritic Cells and Is Highly Sensitive to the Antiviral Actions of Interferons

(2009) P. Osterlund et al.   JOURNAL OF VIROLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

(2009) C. R. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria primes the innate immune response due to interferon-  induced enhancement of toll-like receptor expression and function

(2009) B. S. Franklin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes

(2009) Cristian Cillóniz et al.   PLoS Pathogens

The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome

(2008) Houli Wang et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis

(2008) Mark M. Wurfel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Presenting and exploring biological pathways with PathVisio

(2008) Martijn P van Iersel et al.   BMC BIOINFORMATICS

Clinical uses of interferons

(2008) Robert M. Friedman   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Genetic Insights into Sepsis: What have we Learned and How will it Help?

(2008) M. Wurfel   CURRENT PHARMACEUTICAL DESIGN

A20: Central Gatekeeper in Inflammation and Immunity

(2008) Beatrice Coornaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperinduction of Cyclooxygenase‐2–Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection

(2008) Suki M. Y. Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Integration of metabolism and inflammation by lipid-activated nuclear receptors

(2008) Steven J. Bensinger et al.   NATURE

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

Insights into Inflammation and Influenza

(2008) Cameron Simmons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antimalarial Drug Quality in the Most Severely Malarious Parts of Africa – A Six Country Study

(2008) Roger Bate et al.   PLoS One

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

(2008) B.-J. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens