期刊
CYTOKINE
卷 43, 期 3, 页码 359-367出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2008.07.012
关键词
Ubiquitination; Phosphorylation; Interferon; Pattern-recognition receptors; Innate immunity
资金
- Canadian Institutes of Health Research (CIHR) [MOP-84571]
Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate genes involved in their clearance, a concept known as innate immunity. While phosphorylation mechanisms play essential roles in regulating different aspects of the innate immune response, ubiquitination is now recognized as another post-translational modification that works in parallel with phosphorylation to orchestrate the final proper innate immune response against invading pathogens. More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling. (C) 2008 Elsevier Ltd. All rights reserved.
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