Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

(2015) Zhifen Yang et al.   Scientific Reports

Mechanisms and pathways of innate immune activation and regulation in health and cancer

(2015) Jun Cui et al.   Human Vaccines & Immunotherapeutics

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Cellular Sensing of Viral DNA and Viral Evasion Mechanisms

(2014) Megan H. Orzalli et al.   Annual Review of Microbiology

Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response

(2014) Ricardo Rajsbaum et al.   IMMUNITY

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF- B Activation

(2014) H. Shinohara et al.   SCIENCE

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex

(2013) Xikui Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

(2010) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

(2010) Savaş Tay et al.   NATURE

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

High-Affinity Interaction between IKKβ and NEMO

(2008) Yu-Chih Lo et al.   BIOCHEMISTRY

Dynamical modeling and multi-experiment fitting with PottersWheel

(2008) Thomas Maiwald et al.   BIOINFORMATICS

Dynamic sensitivity analysis of biological systems

(2008) Wu Wu et al.   BMC BIOINFORMATICS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior

(2008) Beatrice Rivière et al.   MATHEMATICAL BIOSCIENCES

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE