Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

(2015) Li Li et al.   Nature Chemical Biology

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

The Nuclear Receptor Nr4a1 Controls CD8 T Cell Development Through Transcriptional Suppression of Runx3

(2015) Heba N. Nowyhed et al.   Scientific Reports

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation

(2014) S.-H. Yi et al.   DEVELOPMENT

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stress and glucocorticoid regulation of NR4A genes in mice

(2014) Jean-Christophe Helbling et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

(2012) Yasunobu Arima et al.   CELL

Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

(2012) Marco Cosentino et al.   Journal of Neuroimmune Pharmacology

Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse

(2012) Peter J Gaskill et al.   Journal of Neuroinflammation

Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision

(2012) C. R. Jackson et al.   JOURNAL OF NEUROSCIENCE

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Chronic in vivo imaging in the mouse spinal cord using an implanted chamber

(2012) Matthew J Farrar et al.   NATURE METHODS

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic epithelial NF- B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

(2012) H. Shaked et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation: a role for NR4A orphan nuclear receptors?

(2011) Jason P. McMorrow et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

(2011) Anouk A.J. Hamers et al.   CIRCULATION RESEARCH

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the multiple sclerosis traits: Nuclear receptors (NR) impaired apoptosis pathway and the role of 1-alpha 25-dihydroxyvitamin D3

(2011) Anat Achiron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

(2011) Danae Campos-Melo et al.   NEUROTOXICITY RESEARCH

Prolonged Membrane Depolarization Enhances Midbrain Dopamine Neuron Differentiation via Epigenetic Histone Modifications

(2011) Xi-Biao He et al.   STEM CELLS

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

(2011) Takashi Sekiya et al.   Nature Communications

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease

(2010) K. L. Wallace et al.   BLOOD

In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response

(2010) Zhigang Fan et al.   NATURE MEDICINE

Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis

(2010) Anat Achiron et al.   NEUROBIOLOGY OF DISEASE

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy

(2007) Dimitrios Davalos et al.   JOURNAL OF NEUROSCIENCE METHODS