Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing
出版年份 2020 全文链接
标题
Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing
作者
关键词
CRISPR, Chemical modifications, Nucleic acids, Genome editing, Gene therapy
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume 168, Issue -, Pages 246-258
出版商
Elsevier BV
发表日期
2020-10-27
DOI
10.1016/j.addr.2020.10.014
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses
- (2020) Tuan M. Nguyen et al. CELL RESEARCH
- Covid-19 — Navigating the Uncharted
- (2020) Anthony S. Fauci et al. NEW ENGLAND JOURNAL OF MEDICINE
- Conditional control of RNA-guided nucleic acid cleavage and gene editing
- (2020) Shao-Ru Wang et al. Nature Communications
- Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
- (2020) Jonathan M. Levy et al. Nature Biomedical Engineering
- Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light‐Activated Guide RNA
- (2020) Wenyuan Zhou et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza
- (2020) Timothy R. Abbott et al. CELL
- Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
- (2020) Tingting Jiang et al. Nature Communications
- Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation
- (2020) Elena V. Moroz-Omori et al. ACS Central Science
- Very fast CRISPR on demand
- (2020) Yang Liu et al. SCIENCE
- CRISPR–Cas: a tool for cancer research and therapeutics
- (2019) Hao Yin et al. Nature Reviews Clinical Oncology
- In vitro transcribed sgRNA causes cell death by inducing interferon release
- (2019) Wei Mu et al. Protein & Cell
- CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells
- (2019) Yi-Li Min et al. Science Advances
- RNA Modifications Modulate Activation of Innate Toll-Like Receptors
- (2019) Isabel Freund et al. Genes
- Improving CRISPR Genome Editing by Engineering Guide RNAs
- (2019) Su Bin Moon et al. TRENDS IN BIOTECHNOLOGY
- Identification of preexisting adaptive immunity to Cas9 proteins in humans
- (2019) Carsten T. Charlesworth et al. NATURE MEDICINE
- Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
- (2019) Christopher E. Nelson et al. NATURE MEDICINE
- Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
- (2019) Benjamin P. Kleinstiver et al. NATURE BIOTECHNOLOGY
- Faster, better, cheaper: the rise of CRISPR in disease detection
- (2019) Amy Maxmen NATURE
- Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9
- (2019) Hong-Xia Zhang et al. MOLECULAR THERAPY
- Adenine base editing in an adult mouse model of tyrosinaemia
- (2019) Chun-Qing Song et al. Nature Biomedical Engineering
- Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
- (2019) Julian Grünewald et al. NATURE
- Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations
- (2019) Reza Shahbazi et al. NATURE MATERIALS
- Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9
- (2019) Christopher L. Barkau et al. Nucleic Acid Therapeutics
- CRISPR–Cas9 strikes out in cassava
- (2019) Edward P. Rybicki NATURE BIOTECHNOLOGY
- An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA
- (2019) Lapatrada Taemaitree et al. Nature Communications
- Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
- (2019) Prasanta K. Dash et al. Nature Communications
- Engineering nucleic acid chemistry for precise and controllable CRISPR/Cas9 genome editing
- (2019) Weiqi Cai et al. Science Bulletin
- A boronic acid–rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing
- (2019) Chongyi Liu et al. Science Advances
- A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
- (2019) Guojun Chen et al. Nature Nanotechnology
- Reading, writing and erasing mRNA methylation
- (2019) Sara Zaccara et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- NanoRNP Overcomes Tumor Heterogeneity in Cancer Treatment
- (2019) Qi Liu et al. NANO LETTERS
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs
- (2019) Sukumar Sakamuri et al. CHEMBIOCHEM
- Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency
- (2019) David N. Nguyen et al. NATURE BIOTECHNOLOGY
- An efficient gene knock-in strategy using 5′-modified double-stranded DNA donors with short homology arms
- (2019) Yi Yu et al. Nature Chemical Biology
- Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing
- (2019) Yuan Rui et al. Science Advances
- Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles
- (2018) Ying-Li Luo et al. ACS Nano
- Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy
- (2018) Peng Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Chimeric Guides Probe and Enhance Cas9 Biochemical Activity
- (2018) Zachary J. Kartje et al. BIOCHEMISTRY
- Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine
- (2018) Hyokyoung Kwon et al. BIOMATERIALS
- Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
- (2018) Silvana Konermann et al. CELL
- CRISPR RNAs trigger innate immune responses in human cells
- (2018) Sojung Kim et al. GENOME RESEARCH
- Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein
- (2018) Winston X. Yan et al. MOLECULAR CELL
- Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells
- (2018) Moira A. McMahon et al. MOLECULAR THERAPY
- Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
- (2018) Seuk-Min Ryu et al. NATURE BIOTECHNOLOGY
- Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
- (2018) Michael Kosicki et al. NATURE BIOTECHNOLOGY
- Optimized base editors enable efficient editing in cells, organoids and mice
- (2018) Maria Paz Zafra et al. NATURE BIOTECHNOLOGY
- Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
- (2018) Hao Yin et al. Nature Chemical Biology
- CRISPR/Cas9 genome editing in human hematopoietic stem cells
- (2018) Rasmus O Bak et al. Nature Protocols
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity
- (2018) Christopher R. Cromwell et al. Nature Communications
- Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
- (2018) Aamir Mir et al. Nature Communications
- A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
- (2018) Jonathan D. Finn et al. Cell Reports
- In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
- (2018) Beeke Wienert et al. PLOS BIOLOGY
- Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population
- (2018) Vijaya L. Simhadri et al. Molecular Therapy-Methods & Clinical Development
- Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours
- (2018) Bumwhee Lee et al. Nature Biomedical Engineering
- In vivo CRISPR editing with no detectable genome-wide off-target mutations
- (2018) Pinar Akcakaya et al. NATURE
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- Engineered CRISPR-Cas9 nuclease with expanded targeting space
- (2018) Hiroshi Nishimasu et al. SCIENCE
- Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo
- (2018) Hyo Min Park et al. Nature Communications
- Efficient single-copy HDR by 5’ modified long dsDNA donors
- (2018) Jose Arturo Gutierrez-Triana et al. eLife
- Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9
- (2018) Lupeng Ye et al. Cell Discovery
- Bacteriophage T7 transcription system: an enabling tool in synthetic biology
- (2018) Wenya Wang et al. BIOTECHNOLOGY ADVANCES
- Base editing: precision chemistry on the genome and transcriptome of living cells
- (2018) Holly A. Rees et al. NATURE REVIEWS GENETICS
- Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing
- (2018) Bin Li et al. Cell Reports
- Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
- (2017) Shuaijian Ni et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
- (2017) Janice S. Chen et al. NATURE
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
- (2017) Naoki Iwamoto et al. NATURE BIOTECHNOLOGY
- Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
- (2017) Hao Yin et al. NATURE BIOTECHNOLOGY
- Delivery technologies for genome editing
- (2017) Hao Yin et al. NATURE REVIEWS DRUG DISCOVERY
- Improving CRISPR–Cas specificity with chemical modifications in single-guide RNAs
- (2017) Daniel E Ryan et al. NUCLEIC ACIDS RESEARCH
- RNA editing with CRISPR-Cas13
- (2017) David B. T. Cox et al. SCIENCE
- Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease
- (2017) Fernando Orden Rueda et al. Nature Communications
- CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
- (2017) Françoise S Howe et al. eLife
- Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering
- (2017) Kunwoo Lee et al. eLife
- Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
- (2017) Bin Li et al. Nature Biomedical Engineering
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
- (2017) Kunwoo Lee et al. Nature Biomedical Engineering
- Minimal 2'-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity
- (2017) Megan Basila et al. PLoS One
- Chemical and structural modifications of RNAi therapeutics
- (2016) Sook Hee Ku et al. ADVANCED DRUG DELIVERY REVIEWS
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors
- (2016) Piyush K. Jain et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Conjugation and Evaluation of Triazole-Linked Single Guide RNA for CRISPR-Cas9 Gene Editing
- (2016) Kaizhang He et al. CHEMBIOCHEM
- Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications
- (2016) Konstantin Licht et al. JOURNAL OF CELL BIOLOGY
- Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression
- (2016) Irene C Turnbull et al. MOLECULAR THERAPY
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
- (2016) Christopher D Richardson et al. NATURE BIOTECHNOLOGY
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- A multifunctional AAV–CRISPR–Cas9 and its host response
- (2016) Wei Leong Chew et al. NATURE METHODS
- Aptamers as targeted therapeutics: current potential and challenges
- (2016) Jiehua Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose
- (2016) Jasdave S. Chahal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
- (2016) Omar O. Abudayyeh et al. SCIENCE
- Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
- (2016) M. A. DeWitt et al. Science Translational Medicine
- Engineering Delivery Vehicles for Genome Editing
- (2016) Christopher E. Nelson et al. Annual Review of Chemical and Biomolecular Engineering
- Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
- (2016) Tony Gutschner et al. Cell Reports
- Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases
- (2016) Jean-Baptiste Renaud et al. Cell Reports
- Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases
- (2016) Diane Yang et al. Scientific Reports
- Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
- (2015) Wujin Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish
- (2015) Julien Ablain et al. DEVELOPMENTAL CELL
- Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs
- (2015) Linlin Yin et al. GENETICS
- Adenovirus-Mediated Somatic Genome Editing ofPtenby CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses
- (2015) Dan Wang et al. HUMAN GENE THERAPY
- Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection
- (2015) Xiquan Liang et al. JOURNAL OF BIOTECHNOLOGY
- Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
- (2015) Sergey Shmakov et al. MOLECULAR CELL
- Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature
- (2015) Omar F. Khan et al. NANO LETTERS
- Synthesis and applications of RNAs with position-selective labelling and mosaic composition
- (2015) Yu Liu et al. NATURE
- Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
- (2015) Takeshi Maruyama et al. NATURE BIOTECHNOLOGY
- Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
- (2015) Ayal Hendel et al. NATURE BIOTECHNOLOGY
- In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency
- (2015) Azita J Mahiny et al. NATURE BIOTECHNOLOGY
- DNA-binding-domain fusions enhance the targeting range and precision of Cas9
- (2015) Mehmet Fatih Bolukbasi et al. NATURE METHODS
- An updated evolutionary classification of CRISPR–Cas systems
- (2015) Kira S. Makarova et al. NATURE REVIEWS MICROBIOLOGY
- Discovery of m7G-cap in eukaryotic mRNAs
- (2015) Yasuhiro FURUICHI PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Synthetic CRISPR RNA-Cas9–guided genome editing in human cells
- (2015) Meghdad Rahdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rationally engineered Cas9 nucleases with improved specificity
- (2015) I. M. Slaymaker et al. SCIENCE
- Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs
- (2015) Hartmut Jahns et al. Nature Communications
- Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs
- (2015) Linlin Yin et al. GENETICS
- The basic building blocks and evolution of CRISPR–Cas systems
- (2015) Kira S. Makarova et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
- (2014) S. Kim et al. GENOME RESEARCH
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
- (2014) John A Zuris et al. NATURE BIOTECHNOLOGY
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
- (2014) John P Guilinger et al. NATURE BIOTECHNOLOGY
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
- (2014) Hao Yin et al. NATURE BIOTECHNOLOGY
- In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
- (2014) James E. Dahlman et al. Nature Nanotechnology
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- In Vivo Ligands of MDA5 and RIG-I in Measles Virus-Infected Cells
- (2014) Simon Runge et al. PLoS Pathogens
- Pol III Promoters to Express Small RNAs: Delineation of Transcription Initiation
- (2014) Hongming Ma et al. Molecular Therapy-Nucleic Acids
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format
- (2013) Kyle K.L. Phua et al. JOURNAL OF CONTROLLED RELEASE
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing
- (2012) Glen F. Deleavey et al. CHEMISTRY & BIOLOGY
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
- (2012) Qian Feng et al. Cell Reports
- Silencing disease genes in the laboratory and the clinic
- (2011) Jonathan K Watts et al. JOURNAL OF PATHOLOGY
- Streamlined Process for the Chemical Synthesis of RNA Using 2′-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase
- (2011) Douglas J. Dellinger et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
- (2011) Elitza Deltcheva et al. NATURE
- Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
- (2011) Michael S D Kormann et al. NATURE BIOTECHNOLOGY
- Evolution and classification of the CRISPR–Cas systems
- (2011) Kira S. Makarova et al. NATURE REVIEWS MICROBIOLOGY
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Clinical status of duplex RNA
- (2010) Jonathan K. Watts et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
- (2010) Luigi Warren et al. Cell Stem Cell
- siRNA delivery systems for cancer treatment
- (2009) Yu-Kyoung Oh et al. ADVANCED DRUG DELIVERY REVIEWS
- A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation
- (2009) X. Zheng et al. BLOOD
- Chemically modified siRNA: tools and applications
- (2008) J WATTS et al. DRUG DISCOVERY TODAY
- The Business of RNAi Therapeutics
- (2008) Dirk Haussecker HUMAN GENE THERAPY
- Design, Synthesis, and Properties of 2‘,4‘-BNANC: A Bridged Nucleic Acid Analogue
- (2008) S. M. Abdur Rahman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
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