Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs

miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19–miR-106a interaction

(2014) Jochen Imig et al.   Nature Chemical Biology

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

(2014) W. Brad Wan et al.   NUCLEIC ACIDS RESEARCH

Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF- 

(2013) B. Guennewig et al.   RNA

Coupling activators for the oligonucleotide synthesis via phosphoramidite approach

(2013) Xia Wei   TETRAHEDRON

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′-O-(2-Cyanoethoxymethyl)-nucleoside 3′-O-Oxazaphospholidine Monomers

(2012) Yohei Nukaga et al.   JOURNAL OF ORGANIC CHEMISTRY

Target mRNA inhibition by oligonucleotide drugs in man

(2012) H. L. Lightfoot et al.   NUCLEIC ACIDS RESEARCH

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

(2011) Piotr Guga et al.   CHEMISTRY & BIODIVERSITY

Sulfurization of Dinucleoside Phosphite Triesters with Chiral Disulfides

(2011) Joshua A. Mukhlall et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects

(2011) S. Petri et al.   RNA

Off-Target Effects Related to the Phosphorothioate Modification of Nucleic Acids

(2010) Johannes Winkler et al.   ChemMedChem

microRNA profiling in Epstein–Barr virus-associated B-cell lymphoma

(2010) Jochen Imig et al.   NUCLEIC ACIDS RESEARCH

Modulation of thermal stability can enhance the potency of siRNA

(2010) H. Addepalli et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Binding and Cleavage Specificities of Human Argonaute2

(2009) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

(2009) Natsuhisa Oka et al.   ORGANIC LETTERS