Aptamers as targeted therapeutics: current potential and challenges

Embracing proteins: structural themes in aptamer–protein complexes

(2016) Amy D Gelinas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An aptamer-antibody complex (oligobody) as a novel delivery platform for targeted cancer therapies

(2016) Kyun Heo et al.   JOURNAL OF CONTROLLED RELEASE

An anticoagulant too good to be true for revascularisation

(2016) Freek W A Verheugt   LANCET

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

(2016) A Michael Lincoff et al.   LANCET

Smooth Muscle Cell–targeted RNA Aptamer Inhibits Neointimal Formation

(2016) William H Thiel et al.   MOLECULAR THERAPY

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Aptamers as radiopharmaceuticals for nuclear imaging and therapy

(2016) Marlies Gijs et al.   NUCLEAR MEDICINE AND BIOLOGY

Fit for the Eye: Aptamers in Ocular Disorders

(2016) Daniel W. Drolet et al.   Nucleic Acid Therapeutics

Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

(2016) Erin E. Soule et al.   Nucleic Acid Therapeutics

2′Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors

(2016) Youngju Lee et al.   Nucleic Acid Therapeutics

Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

(2015) Dan Shu et al.   ACS Nano

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

(2015) Yeh-Hsing Lao et al.   ACS Nano

The roles of nucleolin subcellular localization in cancer

(2015) Caroline Madeleine Berger et al.   BIOCHIMIE

2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia

(2015) Mario Martinez Soldevilla et al.   BIOMATERIALS

Current approaches in SELEX: An update to aptamer selection technology

(2015) Mariia Darmostuk et al.   BIOTECHNOLOGY ADVANCES

Hi-Fi SELEX: A high-fidelity digital-PCR based therapeutic aptamer discovery platform

(2015) Eric Ouellet et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cancer immunotherapy via nucleic acid aptamers

(2015) Mostafa Khedri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Selective delivery of therapeutic single strand antimiRs by aptamer-based conjugates

(2015) Silvia Catuogno et al.   JOURNAL OF CONTROLLED RELEASE

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

(2015) Chao Liang et al.   NATURE MEDICINE

Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment

(2015) Agata Levay et al.   NUCLEIC ACIDS RESEARCH

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

(2015) Na-Oh Yunn et al.   NUCLEIC ACIDS RESEARCH

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

(2015) Jan Hoinka et al.   NUCLEIC ACIDS RESEARCH

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy

(2015) Lukas J Aaldering et al.   RNA Biology

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

(2015) Dominik Oberthür et al.   Nature Communications

DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist

(2015) Vidhya Ramaswamy et al.   Nucleic Acid Therapeutics

Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein

(2015) Chang Ho Lee et al.   Molecular Therapy-Nucleic Acids

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Emulsion PCR Significantly Improves Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures-Based Aptamer Selection: Allowing for Efficient and Rapid Selection of Aptamer to Unmodified ABH2 Protein

(2014) Roman Yufa et al.   ANALYTICAL CHEMISTRY

NOX-A12: mobilizing CLL away from home

(2014) R. Marasca et al.   BLOOD

Effect of pegaptanib sodium 0.3 mg intravitreal injections (Macugen) in intraocular pressure: posthoc analysis from V.I.S.I.O.N. study

(2014) David S Boyer et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Probing the Coagulation Pathway with Aptamers Identifies Combinations that Synergistically Inhibit Blood Clot Formation

(2014) Kristin M. Bompiani et al.   CHEMISTRY & BIOLOGY

Factor IXa as a target for anticoagulation in thrombotic disorders and conditions

(2014) Dia A. Smiley et al.   DRUG DISCOVERY TODAY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Radiolabeling Strategies for Tumor-Targeting Proteinaceous Drugs

(2014) Grant Sugiura et al.   MOLECULES

Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study

(2014) Thomas J. Povsic et al.   EuroIntervention

New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization

(2014) Abdullah Ozer et al.   Molecular Therapy-Nucleic Acids

Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy

(2014) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Stable RNA nanoparticles as potential new generation drugs for cancer therapy

(2013) Yi Shu et al.   ADVANCED DRUG DELIVERY REVIEWS

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

(2013) J. Hoellenriegel et al.   BLOOD

Use of Oligonucleotide Aptamer Ligands to Modulate the Function of Immune Receptors

(2013) E. Gilboa et al.   CLINICAL CANCER RESEARCH

Adverse events and complications associated with intravitreal injection of anti-VEGF agents: a review of literature

(2013) K Ghasemi Falavarjani et al.   EYE

Immunogenicity of therapeutic proteins: Influence of aggregation

(2013) Kirsty D. Ratanji et al.   Journal of Immunotoxicology

Vitreous Inflammation Associated with Intravitreal Anti-VEGF Pharmacotherapy

(2013) Shivi Agrawal et al.   MEDIATORS OF INFLAMMATION

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats

(2013) Shie-Chau Liu et al.   NEURO-ONCOLOGY

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

(2013) Olcay Boyacioglu et al.   Molecular Therapy-Nucleic Acids

CD28 Aptamers as Powerful Immune Response Modulators

(2013) Fernando Pastor et al.   Molecular Therapy-Nucleic Acids

In vivo SELEX for Identification of Brain-penetrating Aptamers

(2013) Congsheng Cheng et al.   Molecular Therapy-Nucleic Acids

Aptamer selection by high-throughput sequencing and informatic analysis

(2012) Shawn Hoon et al.   BIOTECHNIQUES

A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial

(2012) Thomas J. Povsic et al.   EUROPEAN HEART JOURNAL

Therapeutic RNA aptamers in clinical trials

(2012) Padma Sundaram et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

(2012) Jiehua Zhou et al.   MOLECULAR THERAPY

Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration

(2012) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer

(2012) Domenica Musumeci et al.   PHARMACOLOGY & THERAPEUTICS

Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

(2012) William H. Thiel et al.   PLoS One

Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor

(2011) E. K. Waters et al.   BLOOD

Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy

(2011) T. J. Povsic et al.   EUROPEAN HEART JOURNAL

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

(2011) Xiaohua Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Emulsion PCR: A High Efficient Way of PCR Amplification of Random DNA Libraries in Aptamer Selection

(2011) Keke Shao et al.   PLoS One

SUSTAINED ELEVATED INTRAOCULAR PRESSURES AFTER INTRAVITREAL INJECTION OF BEVACIZUMAB, RANIBIZUMAB, AND PEGAPTANIB

(2011) Daniel Y Choi et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Nucleotide Bias Observed with a Short SELEX RNA Aptamer Library

(2011) William H. Thiel et al.   Nucleic Acid Therapeutics

A streamlined protocol for emulsion polymerase chain reaction and subsequent purification

(2010) Tatjana Schütze et al.   ANALYTICAL BIOCHEMISTRY

Current Status of Vascular Endothelial Growth Factor Inhibition in Age-Related Macular Degeneration

(2010) Shaker A. Mousa et al.   BIODRUGS

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Engineering Dendritic Aptamer Assemblies as Superior Inhibitors of Protein Function

(2010) Youngmi Kim et al.   Chemistry-An Asian Journal

First Clinical Application of an Actively Reversible Direct Factor IXa Inhibitor as an Anticoagulation Strategy in Patients Undergoing Percutaneous Coronary Intervention

(2010) Mauricio G. Cohen et al.   CIRCULATION

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Expanding the Chemistry of DNA for in Vitro Selection

(2010) Jonathan D. Vaught et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A dual-targeting PDGFRβ/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo

(2010) Robert Mabry et al.   mAbs

Molecular Evolution of Functional Nucleic Acids with Chemical Modifications

(2010) Masayasu Kuwahara et al.   MOLECULES

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

(2010) Fernando Pastor et al.   NATURE

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures

(2010) Günter Mayer et al.   Nature Protocols

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Pitfalls of Cell-Systematic Evolution of Ligands by Exponential Enrichment (SELEX): Existing Dead Cells During In Vitro Selection Anticipate the Enrichment of Specific Aptamers

(2010) Meltem Avci-Adali et al.   OLIGONUCLEOTIDES

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

(2010) M. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease

(2010) Petra Paulinska et al.   THROMBOSIS AND HAEMOSTASIS

Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura

(2010) Bernd Jilma et al.   THROMBOSIS AND HAEMOSTASIS

Targeting cancer cells with nucleic acid aptamers

(2010) Laura Cerchia et al.   TRENDS IN BIOTECHNOLOGY

A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle

(2010) Hoshang J Unwalla et al.   Virology Journal

The Chemical Biology of Aptamers

(2009) Günter Mayer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX)

(2009) Chao-June Huang et al.   BIOSENSORS & BIOELECTRONICS

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes

(2009) S. G. Sayyed et al.   DIABETOLOGIA

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

VEGF inhibitors for the treatment of neovascular age-related macular degeneration

(2009) Mark Rami Barakat et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The molecular mechanisms of immunomodulation and tolerance induction to factor VIII

(2009) B. WATERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Hybrid DNA Aptamer-Dendrimer Nanomaterial for Targeted Cell Labeling

(2009) Jing Zhou et al.   MACROMOLECULAR BIOSCIENCE

Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers

(2009) Rakesh N. Veedu et al.   Molecular BioSystems

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

(2009) S. Soundararajan et al.   MOLECULAR PHARMACOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

In vivo selection of tumor-targeting RNA motifs

(2009) Jing Mi et al.   Nature Chemical Biology

Selection of DNA aptamers using atomic force microscopy

(2009) Yusuke Miyachi et al.   NUCLEIC ACIDS RESEARCH

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

The Complement Component 5 Gene and Age-Related Macular Degeneration

(2009) Dominique C. Baas et al.   OPHTHALMOLOGY

Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin

(2009) S. M. Nimjee et al.   RNA

Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

(2008) Volha Ninichuk et al.   AMERICAN JOURNAL OF PATHOLOGY

Applications of aptamers in cancer cell biology

(2008) Joseph A. Phillips et al.   ANALYTICA CHIMICA ACTA

Enrichment of Cell‐Targeting and Population‐Specific Aptamers by Fluorescence‐Activated Cell Sorting

(2008) Marie‐Sophie L. Raddatz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

Cell-Specific Induction of Apoptosis by Rationally Designed Bivalent Aptamer-siRNA Transcripts Silencing Eukaryotic Elongation Factor 2

(2008) Ulrich Wullner et al.   CURRENT CANCER DRUG TARGETS

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

(2008) Ke-Tai Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Cell-Specific Internalization Study of an Aptamer from Whole Cell Selection

(2007) Zeyu Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL