Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

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Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs

(2015) Hartmut Jahns et al.   Nature Communications

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

(2014) W. Brad Wan et al.   NUCLEIC ACIDS RESEARCH

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

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Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B

(2012) Stanley T. Crooke et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′-O-(2-Cyanoethoxymethyl)-nucleoside 3′-O-Oxazaphospholidine Monomers

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Rapid HATU-Mediated Solution Phase siRNA Conjugation

(2011) Jeffrey G. Aaronson et al.   BIOCONJUGATE CHEMISTRY

Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms

(2011) Natsuhisa Oka et al.   CHEMICAL SOCIETY REVIEWS

Silencing disease genes in the laboratory and the clinic

(2011) Jonathan K Watts et al.   JOURNAL OF PATHOLOGY

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Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

(2009) Natsuhisa Oka et al.   ORGANIC LETTERS

Stereocontrolled Solid-Phase Synthesis of OligonucleosideH-Phosphonates by an Oxazaphospholidine Approach

(2008) Naoki Iwamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid-Phase Synthesis of Stereoregular Oligodeoxyribonucleoside Phosphorothioates Using Bicyclic Oxazaphospholidine Derivatives as Monomer Units

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