Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

(2018) Tian Zhou et al.   BIOMATERIALS

HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication

(2018) Jonathan Herskovitz et al.   Journal of Neuroimmune Pharmacology

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

(2018) Tian Zhou et al.   Nanomedicine

Creation of a long-acting nanoformulated dolutegravir

(2018) Brady Sillman et al.   Nature Communications

Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution

(2018) Bhavesh D. Kevadiya et al.   Theranostics

Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice

(2018) Ramona Bella et al.   Molecular Therapy-Nucleic Acids

Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities

(2018) Brendan M. Ottemann et al.   BIOMATERIALS

Long-acting slow effective release antiretroviral therapy

(2017) Benson Edagwa et al.   Expert Opinion on Drug Delivery

Creation of a Long-Acting Nanoformulated 2′,3′-Dideoxy-3′-Thiacytidine

(2017) Dongwei Guo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

(2017) Divya Prakash Gnanadhas et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models

(2017) Chaoran Yin et al.   MOLECULAR THERAPY

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy

(2017) Mariluz Araínga et al.   Retrovirology

Humanized Mouse Models for Human Immunodeficiency Virus Infection

(2017) Matthew D. Marsden et al.   Annual Review of Virology

Progress Toward HIV Eradication: Case Reports, Current Efforts, and the Challenges Associated with Cure

(2016) Alyssa R. Martin et al.   Annual Review of Medicine

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

(2016) R Kaminski et al.   GENE THERAPY

Recent developments in the effort to cure HIV infection: going beyond N = 1

(2016) Janet D. Siliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and characterization of a long-acting nanoformulated abacavir prodrug

(2016) Dhirender Singh et al.   Nanomedicine

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

(2016) Gang Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

International AIDS Society global scientific strategy: towards an HIV cure 2016

(2016) Steven G Deeks et al.   NATURE MEDICINE

Sustained virologic control in SIV+ macaques after antiretroviral and  4 7 antibody therapy

(2016) S. N. Byrareddy et al.   SCIENCE

Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape

(2016) Martyn K. White et al.   PLoS Pathogens

HIV-1 cellular and tissue replication patterns in infected humanized mice

(2016) Mariluz Araínga et al.   Scientific Reports

Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing

(2016) Rafal Kaminski et al.   Scientific Reports

Negative Feedback Regulation of HIV-1 by Gene Editing Strategy

(2016) Rafal Kaminski et al.   Scientific Reports

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice

(2015) Pavan Puligujja et al.   ANTIVIRAL RESEARCH

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

(2015) Pavan Puligujja et al.   BIOMATERIALS

Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice

(2015) Michael D Boska et al.   Molecular Neurodegeneration

Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies

(2014) Benson Edagwa et al.   CURRENT MEDICINAL CHEMISTRY

Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance

(2014) D. Guo et al.   JOURNAL OF VIROLOGY

Long-Term Antiretroviral Treatment Initiated at Primary HIV-1 Infection Affects the Size, Composition, and Decay Kinetics of the Reservoir of HIV-1-Infected CD4 T Cells

(2014) M. J. Buzon et al.   JOURNAL OF VIROLOGY

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

(2013) J. A. Horwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

(2012) Prasanta K. Dash et al.   AIDS

Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

(2012) Santhi Gorantla et al.   Journal of Neuroimmune Pharmacology

Rodent models for HIV-associated neurocognitive disorders

(2012) Santhi Gorantla et al.   TRENDS IN NEUROSCIENCES

Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice

(2011) P. K. Dash et al.   JOURNAL OF NEUROSCIENCE

Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis

(2010) Santhi Gorantla et al.   AMERICAN JOURNAL OF PATHOLOGY

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages

(2010) Ari S. Nowacek et al.   JOURNAL OF CONTROLLED RELEASE

The Detection of Acute HIV Infection

(2010) Myron S. Cohen et al.   JOURNAL OF INFECTIOUS DISEASES

Nanoformulated Antiretroviral Drug Combinations Extend Drug Release and Antiretroviral Responses in HIV-1-Infected Macrophages: Implications for NeuroAIDS Therapeutics

(2010) Ari S. Nowacek et al.   Journal of Neuroimmune Pharmacology

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

(2010) Shantanu Balkundi et al.   Jove-Journal of Visualized Experiments

Macrophage Delivery of Nanoformulated Antiretroviral Drug to the Brain in a Murine Model of NeuroAIDS

(2009) H. Dou et al.   JOURNAL OF IMMUNOLOGY

Detecting HIV-1 integration by repetitive-sampling Alu-gag PCR

(2009) Megan K. Liszewski et al.   METHODS

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Review of the Pharmacokinetics of Abacavir

(2008) Geoffrey J Yuen et al.   CLINICAL PHARMACOKINETICS

Highly Sensitive Methods Based on Seminested Real-Time Reverse Transcription-PCR for Quantitation of Human Immunodeficiency Virus Type 1 Unspliced and Multiply Spliced RNA and Proviral DNA

(2008) A. O. Pasternak et al.   JOURNAL OF CLINICAL MICROBIOLOGY