标题
The quest to slow ageing through drug discovery
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-05-28
DOI
10.1038/s41573-020-0067-7
参考文献
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- A pharmacological network for lifespan extension inCaenorhabditis elegans
- (2013) Xiaolan Ye et al. AGING CELL
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
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- Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity
- (2013) Michael J. Conboy et al. AGING CELL
- Glycine metabolism in animals and humans: implications for nutrition and health
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- The Hallmarks of Aging
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- Programmed Cell Senescence during Mammalian Embryonic Development
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- The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
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- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
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- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
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- Metformin: Do we finally have an anti-aging drug?
- (2013) Vladimir N. Anisimov CELL CYCLE
- Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication
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- Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
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- An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
- (2013) Na-Ri Shin et al. GUT
- Rapamycin extends murine lifespan but has limited effects on aging
- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- The Role of Transposable Elements in Health and Diseases of the Central Nervous System
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- Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
- (2013) Sefika Ozcelik et al. PLoS One
- Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review
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- Metformin improves healthspan and lifespan in mice
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- Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans
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- Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression
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- Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres
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- Rapamycin slows aging in mice
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- Role of WNT/β-Catenin Signaling in Rejuvenating Myogenic Differentiation of Aged Mesenchymal Stem Cells from Cardiac Patients
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- Regulation of Immune Responses by mTOR
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- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
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- TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
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- Rejuvenation of Regeneration in the Aging Central Nervous System
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- Ageing as a Risk Factor for Disease
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- Active human retrotransposons: variation and disease
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- Initial metformin or sulphonylurea exposure and cancer occurrence among patients with type 2 diabetes mellitus
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- The Influence of Type 2 Diabetes and Glucose-Lowering Therapies on Cancer Risk in the Taiwanese
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- Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
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- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
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- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
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- Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
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- Systematic Analysis of Cell Cycle Effects of Common Drugs Leads to the Discovery of a Suppressive Interaction between Gemfibrozil and Fluoxetine
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- Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
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- Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
- (2012) Cathy Slack et al. PLoS One
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
- (2012) S. A. Hawley et al. SCIENCE
- An Engineering Approach to Extending Lifespan in C. elegans
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- Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations
- (2012) Christoph Rosak et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity
- (2011) Tsui-Ting Ching et al. AGING CELL
- Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling
- (2011) Smita Majumder et al. AGING CELL
- Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives: Results from a large population-based follow-up study
- (2011) R. Ruiter et al. DIABETES CARE
- Low-dose lithium uptake promotes longevity in humans and metazoans
- (2011) Kim Zarse et al. EUROPEAN JOURNAL OF NUTRITION
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function
- (2011) Saul A. Villeda et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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- Fighting neurodegeneration with rapamycin: mechanistic insights
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- Clinical presentation and management of mTOR inhibitor-associated stomatitis
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- Broadening the therapeutic scope for rapamycin treatment
- (2010) Fiona M. Menzies et al. Autophagy
- [No Title]
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- Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons
- (2010) Rebecca C. Iskow et al. CELL
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure
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- Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases
- (2010) Maurizio Renna et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
- (2010) Richard A. Miller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
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- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects
- (2010) Jorge A. Quiroz et al. NEUROPSYCHOBIOLOGY
- Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
- (2010) Cheol Woong Ha et al. NUCLEIC ACIDS RESEARCH
- Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
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- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
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- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
- (2010) Wen Yang et al. PLOS BIOLOGY
- Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
- (2009) Kathryn Moynihan Ramsey et al. AGING CELL
- Long-term Effects of Metformin on Metabolism and Microvascular and Macrovascular Disease in Patients With Type 2 Diabetes Mellitus
- (2009) Adriaan Kooy et al. ARCHIVES OF INTERNAL MEDICINE
- Lithium levels in drinking water and risk of suicide
- (2009) Hirochika Ohgami et al. BRITISH JOURNAL OF PSYCHIATRY
- Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein
- (2009) Ling He et al. CELL
- New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes
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- The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
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- The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
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- mTOR regulates memory CD8 T-cell differentiation
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- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- Induction of autophagy by spermidine promotes longevity
- (2009) Tobias Eisenberg et al. NATURE CELL BIOLOGY
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- (2009) R. J. Colman et al. SCIENCE
- Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
- (2009) C. Selman et al. SCIENCE
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
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- Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice
- (2008) F.J. Alarcon-Aguilar et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Compounds that confer thermal stress resistance and extended lifespan
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- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Protective effects of NSAIDs on the development of Alzheimer disease
- (2008) Steven C. Vlad et al. NEUROLOGY
- Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition
- (2008) R. Brad Jones et al. PLoS One
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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