标题
Facing up to the global challenges of ageing
作者
关键词
-
出版物
NATURE
Volume 561, Issue 7721, Pages 45-56
出版商
Springer Nature America, Inc
发表日期
2018-08-30
DOI
10.1038/s41586-018-0457-8
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hypertension treatment for older people—navigating between Scylla and Charybdis
- (2018) Simon Paul Conroy et al. AGE AND AGEING
- The role of cellular senescence in aging through the prism of Koch-like criteria
- (2018) Hagai Yanai et al. AGEING RESEARCH REVIEWS
- The Human Gut Microbiome: From Association to Modulation
- (2018) Thomas S.B. Schmidt et al. CELL
- Resveratrol for patients with chronic obstructive pulmonary disease
- (2018) Rosanne J.H.C.G. Beijers et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Aging, inflammation and the environment
- (2018) Arsun Bektas et al. EXPERIMENTAL GERONTOLOGY
- Imaging in metabolic research: challenges and opportunities
- (2018) Vera B. Schrauwen-Hinderling et al. JOURNAL OF APPLIED PHYSIOLOGY
- Back to the future: Epigenetic clock plasticity towards healthy aging
- (2018) Ken Declerck et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts
- (2018) Ramón Estruch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cellular senescence as a therapeutic target to improve renal transplantation outcome
- (2018) Hester van Willigenburg et al. PHARMACOLOGICAL RESEARCH
- Quantitative analysis of population-scale family trees with millions of relatives
- (2018) Joanna Kaplanis et al. SCIENCE
- Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?
- (2018) Klemen Čamernik et al. Stem Cell Reviews and Reports
- Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?
- (2018) Klemen Čamernik et al. Stem Cell Reviews and Reports
- Mechanisms driving the ageing heart
- (2017) Rhys Anderson et al. EXPERIMENTAL GERONTOLOGY
- A comparison of methods for inferring causal relationships between genotype and phenotype using additional biological measurements
- (2017) Holly F. Ainsworth et al. GENETIC EPIDEMIOLOGY
- Body mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study
- (2017) S Stenholm et al. INTERNATIONAL JOURNAL OF OBESITY
- Key proteins and pathways that regulate lifespan
- (2017) Haihui Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Opportunities for organoids as new models of aging
- (2017) Jennifer L. Hu et al. JOURNAL OF CELL BIOLOGY
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- The role of declining adaptive homeostasis in ageing
- (2017) Laura C. D. Pomatto et al. JOURNAL OF PHYSIOLOGY-LONDON
- Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies
- (2017) Kelli L Vaughan et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The Prevalence of Vitamin D Deficiency and the Determinants of 25(OH)D Concentration in Older Irish Adults: Data From The Irish Longitudinal Study on Ageing (TILDA)
- (2017) Eamon Laird et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Four Genome-Wide Association Studies Identify New Extreme Longevity Variants
- (2017) Paola Sebastiani et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble
- (2017) Vasilis Kontis et al. LANCET
- Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women
- (2017) Silvia Stringhini et al. LANCET
- Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study
- (2017) Yi Zeng et al. LANCET
- Brain age predicts mortality
- (2017) J H Cole et al. MOLECULAR PSYCHIATRY
- Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
- (2017) Joseph M. Castellano et al. NATURE
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
- (2017) David J. Stott et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
- (2017) Min Wei et al. Science Translational Medicine
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
- (2017) Peter K. Joshi et al. Nature Communications
- Regulation of life span by the gut microbiota in the short-lived African turquoise killifish
- (2017) Patrick Smith et al. eLife
- Biological Age Predictors
- (2017) Juulia Jylhävä et al. EBioMedicine
- Phenome and genome based studies into human ageing and longevity: An overview
- (2017) P. Eline Slagboom et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Nutritional strategies to optimise cognitive function in the aging brain
- (2016) Devin Wahl et al. AGEING RESEARCH REVIEWS
- Immunochip analysis identifies association of theRAD50/IL13region with human longevity
- (2016) Friederike Flachsbart et al. AGING CELL
- Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer
- (2016) Randy Strong et al. AGING CELL
- Using Electronic Health Records for Population Health Research: A Review of Methods and Applications
- (2016) Joan A. Casey et al. Annual Review of Public Health
- Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2
- (2016) E. B. van den Akker et al. BLOOD
- Whole-Genome Sequencing of a Healthy Aging Cohort
- (2016) Galina A. Erikson et al. CELL
- In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
- (2016) Alejandro Ocampo et al. CELL
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
- (2016) Valter D. Longo et al. Cell Metabolism
- Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity
- (2016) Joris Deelen et al. EXPERIMENTAL GERONTOLOGY
- Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
- (2016) Daniel I Swerdlow et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Colorectal Cancer Screening Recommendations—Reply
- (2016) Kirsten Bibbins-Domingo JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
- (2016) Sebastian I. Arriola Apelo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Strategies and Challenges in Clinical Trials Targeting Human Aging
- (2016) John C. Newman et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Interpretation of the evidence for the efficacy and safety of statin therapy
- (2016) Rory Collins et al. LANCET
- Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
- (2016) Dena Ettehad et al. LANCET
- Evidence for a limit to human lifespan
- (2016) Xiao Dong et al. NATURE
- A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
- (2016) Hubert Plovier et al. NATURE MEDICINE
- Cellular senescence in renal ageing and disease
- (2016) Ines Sturmlechner et al. Nature Reviews Nephrology
- Small nucleoli are a cellular hallmark of longevity
- (2016) Varnesh Tiku et al. Nature Communications
- Genetic and environmental influences interact with age and sex in shaping the human methylome
- (2016) Jenny van Dongen et al. Nature Communications
- Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study
- (2016) Todd E. Druley et al. BMC Geriatrics
- Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
- (2016) Alessandro Bitto et al. eLife
- Hospitalization in older patients due to adverse drug reactions – the need for a prediction tool
- (2016) Nibu Parameswaran Nair et al. Clinical Interventions in Aging
- Health and function of participants in the Long Life Family Study: A comparison with other cohorts
- (2016) Anne B. Newman et al. Aging-US
- Polypharmacy: Misleading, but manageable
- (2016) Reamer Bushardt Clinical Interventions in Aging
- Interventions to Slow Aging in Humans: Are We Ready?
- (2015) Valter D. Longo et al. AGING CELL
- Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
- (2015) Adam P. Sharples et al. AGING CELL
- A proposed panel of biomarkers of healthy ageing
- (2015) Jose Lara et al. BMC Medicine
- The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
- (2015) Bruce Guthrie et al. BMC Medicine
- Promoting Health and Longevity through Diet: From Model Organisms to Humans
- (2015) Luigi Fontana et al. CELL
- Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
- (2015) Jerome Mertens et al. Cell Stem Cell
- Hallmarks of the ageing lung
- (2015) Silke Meiners et al. EUROPEAN RESPIRATORY JOURNAL
- FOXO3: A Major Gene for Human Longevity - A Mini-Review
- (2015) Brian J. Morris et al. GERONTOLOGY
- How Sedentary Are Older People? A Systematic Review of the Amount of Sedentary Behavior
- (2015) Juliet A. Harvey et al. JOURNAL OF AGING AND PHYSICAL ACTIVITY
- Autophagy and neurodegeneration
- (2015) Rebecca A. Frake et al. JOURNAL OF CLINICAL INVESTIGATION
- Measuring Biological Age via Metabonomics: The Metabolic Age Score
- (2015) Johannes Hertel et al. JOURNAL OF PROTEOME RESEARCH
- Reverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population
- (2015) Seyed-Foad Ahmadi et al. Journal of the American Medical Directors Association
- Are Members of Long-Lived Families Healthier Than Their Equally Long-Lived Peers? Evidence From the Long Life Family Study
- (2015) Arlene S. Ash et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of “Aging,” “Life Span,” and “Longevity”
- (2015) Paola Sebastiani et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
- (2015) Tiia Ngandu et al. LANCET
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Quantification of biological aging in young adults
- (2015) Daniel W. Belsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stem cells and healthy aging
- (2015) M. A. Goodell et al. SCIENCE
- Gut microbiota and aging
- (2015) P. W. OToole et al. SCIENCE
- The transcriptional landscape of age in human peripheral blood
- (2015) Marjolein J. Peters et al. Nature Communications
- Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases
- (2015) Sarah J. Mitchell et al. Annual Review of Animal Biosciences
- Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study
- (2015) Lancet Diabetes & Endocrinology
- The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
- (2014) Samantha M. Solon-Biet et al. Cell Metabolism
- Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- (2014) Morgan E. Levine et al. Cell Metabolism
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals
- (2014) Marianne Nygaard et al. EXPERIMENTAL GERONTOLOGY
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
- (2014) Joris Deelen et al. HUMAN MOLECULAR GENETICS
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy
- (2014) Linda Broer et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
- (2014) Ricki J. Colman et al. Nature Communications
- Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study
- (2014) R. Cooper et al. BMJ-British Medical Journal
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Physical and cognitive functioning of people older than 90 years: a comparison of two Danish cohorts born 10 years apart
- (2013) Kaare Christensen et al. LANCET
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- LongevityMap: a database of human genetic variants associated with longevity
- (2013) Arie Budovsky et al. TRENDS IN GENETICS
- DNA methylation age of human tissues and cell types
- (2013) Steve Horvath GENOME BIOLOGY
- Gene expression analysis of mTOR pathway: association with human longevity
- (2012) Willemijn M. Passtoors et al. AGING CELL
- Review: a meta-analysis of GWAS and age-associated diseases
- (2012) William R. Jeck et al. AGING CELL
- Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
- (2012) Thomas A. Rando et al. CELL
- Ageing as a Risk Factor for Disease
- (2012) Teresa Niccoli et al. CURRENT BIOLOGY
- Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
- (2012) S. L. Andersen et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study
- (2012) Karen Barnett et al. LANCET
- Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates
- (2012) Gregory Hannum et al. MOLECULAR CELL
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
- (2012) Julie A. Mattison et al. NATURE
- Human mortality improvement in evolutionary context
- (2012) O. Burger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Telomere length in early life predicts lifespan
- (2012) B. J. Heidinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
- (2011) Joris Deelen et al. AGE
- Aging with multimorbidity: A systematic review of the literature
- (2011) Alessandra Marengoni et al. AGEING RESEARCH REVIEWS
- Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
- (2011) Cagdas Tazearslan et al. AGING CELL
- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
- (2011) Silvie Timmers et al. Cell Metabolism
- Prevalence of Unplanned Hospitalizations Caused by Adverse Drug Reactions in Older Veterans
- (2011) Zachary A. Marcum et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- A genome-wide association study of aging
- (2011) Stefan Walter et al. NEUROBIOLOGY OF AGING
- Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
- (2011) F. H. Sterky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The genetics of ageing
- (2010) Cynthia J. Kenyon NATURE
- Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
- (2010) M. Beekman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
- (2009) Ludmila Pawlikowska et al. AGING CELL
- Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study
- (2009) Rudi G.J. Westendorp et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Poverty and Biological Risk: The Earlier "Aging" of the Poor
- (2009) E. M. Crimmins et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
- (2009) Richard C. Grandison et al. NATURE
- Association ofFOXO3Avariation with human longevity confirmed in German centenarians
- (2009) Friederike Flachsbart et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis
- (2008) Carol Jagger et al. LANCET
- Exceptional longevity does not result in excessive levels of disability
- (2008) K. Christensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FOXO3A genotype is strongly associated with human longevity
- (2008) B. J. Willcox et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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