Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

(2012) Remi-Martin Laberge et al.   AGING CELL

Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose

(2012) Robert Krysiak et al.   ATHEROSCLEROSIS

Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis

(2012) K. Bhalla et al.   Cancer Prevention Research

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example

(2011) Massimiliano Bonafè et al.   BIOESSAYS

Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention

(2011) S. M. Fischer et al.   Cancer Prevention Research

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Targeting PDK1 in Cancer

(2011) C. Raimondi et al.   CURRENT MEDICINAL CHEMISTRY

Opposing roles of NF- B in anti-cancer treatment outcome unveiled by cross-species investigations

(2011) H. Jing et al.   GENES & DEVELOPMENT

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

(2010) M. Pollak   Cancer Prevention Research

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

(2010) Ignacio Medina et al.   NUCLEIC ACIDS RESEARCH

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

(2008) Anthony J. Donato et al.   AGING CELL