标题
Interventions to Slow Aging in Humans: Are We Ready?
作者
关键词
-
出版物
AGING CELL
Volume 14, Issue 4, Pages 497-510
出版商
Wiley
发表日期
2015-04-22
DOI
10.1111/acel.12338
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury
- (2016) Christine R. Mauro et al. JOURNAL OF VASCULAR SURGERY
- Fasting and cancer treatment in humans: A case series report
- (2016) Fernando M. Safdie et al. Aging-US
- Metformin for aging and cancer prevention
- (2016) Vladimir N. Anisimov Aging-US
- Will calorie restriction work in humans?
- (2016) Edda Cava et al. Aging-US
- Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
- (2016) Marco De Cecco et al. Aging-US
- GDF11/Myostatin and aging
- (2016) Vishal K. Patel et al. Aging-US
- Dietary protein restriction inhibits tumor growth in human xenograft models
- (2015) Luigi Fontana et al. Oncotarget
- Growth hormone signaling is necessary for lifespan extension by dietary methionine
- (2014) Holly M. Brown-Borg et al. AGING CELL
- ATF4 activity: a common feature shared by many kinds of slow-aging mice
- (2014) Weiquan Li et al. AGING CELL
- Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
- (2014) Sofiya Milman et al. AGING CELL
- Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life
- (2014) Martin S. Denzel et al. CELL
- Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
- (2014) Zhao V. Wang et al. CELL
- P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage
- (2014) Gelin Wang et al. CELL
- The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice
- (2014) Samantha M. Solon-Biet et al. Cell Metabolism
- Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan
- (2014) Tobias Eisenberg et al. Cell Metabolism
- Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- (2014) Morgan E. Levine et al. Cell Metabolism
- Fasting: Molecular Mechanisms and Clinical Applications
- (2014) Valter D. Longo et al. Cell Metabolism
- Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
- (2014) Chia-Wei Cheng et al. Cell Stem Cell
- Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”
- (2014) Marcello Pinti et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- What is an anti-aging treatment?
- (2014) David Gems EXPERIMENTAL GERONTOLOGY
- New advances in CMV and immunosenescence
- (2014) Paolo Sansoni et al. EXPERIMENTAL GERONTOLOGY
- Commonly used diabetes and cardiovascular medications and cancer recurrence and cancer-specific mortality: a review of the literature
- (2014) Jennifer W Wu et al. Expert Opinion On Drug Safety
- FGF21 is an endocrine signal of protein restriction
- (2014) Thomas Laeger et al. JOURNAL OF CLINICAL INVESTIGATION
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Nordihydroguaiaretic Acid Extends the Lifespan ofDrosophilaand Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice
- (2014) Stephen R. Spindler et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis
- (2014) Heather A. Hausenblas et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
- (2014) Anila K. Madiraju et al. NATURE
- Impact of genomic damage and ageing on stem cell function
- (2014) Axel Behrens et al. NATURE CELL BIOLOGY
- Expert consensus document: A consensus on the medical treatment of acromegaly
- (2014) Andrea Giustina et al. Nature Reviews Endocrinology
- Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells
- (2014) Jay E. Johnson et al. PLoS One
- Protein and amino acid restriction, aging and disease: from yeast to humans
- (2014) Hamed Mirzaei et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- (2014) Basil P. Hubbard et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
- (2014) Diana Jurk et al. Nature Communications
- D-Glucosamine supplementation extends life span of nematodes and of ageing mice
- (2014) Sandra Weimer et al. Nature Communications
- Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice
- (2014) Pavlos Missios et al. Nature Communications
- Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
- (2014) Ricki J. Colman et al. Nature Communications
- The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo
- (2014) Eylul Harputlugil et al. Cell Reports
- Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
- (2014) Mario G. Mirisola et al. PLoS Genetics
- Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
- (2014) Christoph Ruckenstuhl et al. PLoS Genetics
- β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice
- (2013) Stephen R. Spindler et al. AGE
- MicroRNAs linking inflamm-aging, cellular senescence and cancer
- (2013) Fabiola Olivieri et al. AGEING RESEARCH REVIEWS
- Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
- (2013) Edoardo Parrella et al. AGING CELL
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- (2013) Marco De Cecco et al. AGING CELL
- Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways inC. elegans
- (2013) Keunhee Seo et al. AGING CELL
- Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
- (2013) Richard A. Miller et al. AGING CELL
- Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway
- (2013) Yong-Na Zhao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR
- (2013) Jordan Gallinetti et al. BIOCHEMICAL JOURNAL
- Death by transposition - the enemy within?
- (2013) John M. Sedivy et al. BIOESSAYS
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- (2013) Ana P. Gomes et al. CELL
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
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- (2013) Akiko Satoh et al. Cell Metabolism
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- (2013) Yun-Hee Youm et al. Cell Metabolism
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- (2013) Yolanda Jimenez-Gomez et al. Cell Metabolism
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- (2013) Elizabeth A. Schroeder et al. Cell Metabolism
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- (2013) J. L. Fiori et al. DIABETES
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- (2013) Graham Rena et al. DIABETOLOGIA
- Fasting or caloric restriction for Healthy Aging
- (2013) Stephen Anton et al. EXPERIMENTAL GERONTOLOGY
- Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells
- (2013) Angel Mauricio Castro-Gamero et al. INVESTIGATIONAL NEW DRUGS
- Rapalogs and mTOR inhibitors as anti-aging therapeutics
- (2013) Dudley W. Lamming et al. JOURNAL OF CLINICAL INVESTIGATION
- AMPK, insulin resistance, and the metabolic syndrome
- (2013) Neil B. Ruderman et al. JOURNAL OF CLINICAL INVESTIGATION
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
- (2013) J. Graff et al. JOURNAL OF NEUROSCIENCE
- A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study
- (2013) Agnes Berendsen et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin
- (2013) A. M. Marz et al. MOLECULAR AND CELLULAR BIOLOGY
- Tumor glycolysis as a target for cancer therapy: progress and prospects
- (2013) Shanmugasundaram Ganapathy-Kanniappan et al. Molecular Cancer
- Nutrient regulation of the mTOR Complex 1 signaling pathway
- (2013) Sang Gyun Kim et al. MOLECULES AND CELLS
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
- (2013) Xiao Tian et al. NATURE
- Oxidative stress and the ageing endocrine system
- (2013) Giovanni Vitale et al. Nature Reviews Endocrinology
- Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
- (2013) Ziyun Wu et al. PLoS One
- A Histone Mutant Reproduces the Phenotype Caused by Loss of Histone-Modifying Factor Polycomb
- (2013) A. R. Pengelly et al. SCIENCE
- Drugs that modulate aging: the promising yet difficult path ahead
- (2013) Brian K. Kennedy et al. Translational Research
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
- (2013) Sowmya Venkatasubramanian et al. Journal of the American Heart Association
- N-glycomic biomarkers of biological aging and longevity: A link with inflammaging
- (2012) Fabio Dall’Olio et al. AGEING RESEARCH REVIEWS
- Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treatment of ischemic heart disease: Future research needs prioritization
- (2012) Matthew J. Crowley et al. AMERICAN HEART JOURNAL
- A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension
- (2012) Paul Cavuoto et al. CANCER TREATMENT REVIEWS
- A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
- (2012) Jianwei Wang et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
- (2012) Jun Yoshino et al. Cell Metabolism
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- Inflamm-ageing
- (2012) Elisa Cevenini et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome
- (2012) C. Escande et al. DIABETES
- Role of PAPP-A in aging and age-related disease
- (2012) Cheryl A. Conover EXPERIMENTAL GERONTOLOGY
- The pleiotropic effects and therapeutic potential of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in malignancies: A comprehensive review
- (2012) Orlando Santana et al. Journal of Cancer Research and Therapeutics
- Long-Term Safety of Pegvisomant in Patients with Acromegaly: Comprehensive Review of 1288 Subjects in ACROSTUDY
- (2012) A. J. van der Lely et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
- (2012) R. Strong et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
- (2012) Julie A. Mattison et al. NATURE
- Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation
- (2012) Stephen R. Spindler et al. PLoS One
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Surgical Stress Resistance Induced by Single Amino Acid Deprivation Requires Gcn2 in Mice
- (2012) W. Peng et al. Science Translational Medicine
- Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
- (2011) Lixin Dai et al. BMC BIOCHEMISTRY
- Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
- (2011) Silvie Timmers et al. Cell Metabolism
- Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
- (2011) Jun Yoshino et al. Cell Metabolism
- Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies
- (2011) Rachel Steuerman et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
- (2011) Eugenia Morselli et al. JOURNAL OF CELL BIOLOGY
- A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal
- (2011) Husam Ghanim et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Resveratrol and health - A comprehensive review of human clinical trials
- (2011) James M. Smoliga et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction
- (2011) Tobias Sperka et al. NATURE CELL BIOLOGY
- Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
- (2011) John F Trepanowski et al. Nutrition Journal
- Aging Genes: The Sirtuin Story Unravels
- (2011) J. Couzin-Frankel SCIENCE
- Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
- (2011) J. Guevara-Aguirre et al. Science Translational Medicine
- Common toxicities of mammalian target of rapamycin inhibitors
- (2011) Scott A. Soefje et al. Targeted Oncology
- SRT1720 improves survival and healthspan of obese mice
- (2011) Robin K. Minor et al. Scientific Reports
- Recent trends in chronic disease, impairment and disability among older adults in the United States
- (2011) William W Hung et al. BMC Geriatrics
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Glycolytic inhibition as a strategy for developing calorie restriction mimetics
- (2010) Donald K. Ingram et al. EXPERIMENTAL GERONTOLOGY
- Modulation of β-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5
- (2010) David Ho et al. HEART FAILURE REVIEWS
- The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
- (2010) M N Harvie et al. INTERNATIONAL JOURNAL OF OBESITY
- Feedback between p21 and reactive oxygen production is necessary for cell senescence
- (2010) João F Passos et al. Molecular Systems Biology
- Ageing: Much ado about ageing
- (2010) Heidi Ledford NATURE
- Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
- (2010) Elena Biagi et al. PLoS One
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Caloric restriction: From soup to nuts
- (2009) Stephen R. Spindler AGEING RESEARCH REVIEWS
- Evolving understanding of the renin-angiotensin-aldosterone system: Pathophysiology and targets for therapeutic intervention
- (2009) Alan H. Gradman AMERICAN HEART JOURNAL
- Renin–Angiotensin System Blockade and Cardiovascular and Renal Protection
- (2009) Byron J. Hoogwerf AMERICAN JOURNAL OF CARDIOLOGY
- Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid
- (2009) Ross O. Meyers et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
- (2009) A. A. Soukas et al. GENES & DEVELOPMENT
- Long-Term Oral Polyamine Intake Increases Blood Polyamine Concentrations
- (2009) Kuniyasu SODA et al. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
- Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice
- (2009) Y. Ikeno et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Ageing populations: the challenges ahead
- (2009) Kaare Christensen et al. LANCET
- BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
- (2009) J. M. Carboni et al. MOLECULAR CANCER THERAPEUTICS
- Histone H4 lysine 16 acetylation regulates cellular lifespan
- (2009) Weiwei Dang et al. NATURE
- Induction of autophagy by spermidine promotes longevity
- (2009) Tobias Eisenberg et al. NATURE CELL BIOLOGY
- Statins and cardioprotection — More than just lipid lowering?
- (2009) Andrew Ludman et al. PHARMACOLOGY & THERAPEUTICS
- Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats
- (2009) Robin K. Minor et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
- (2008) Randy Strong et al. AGING CELL
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
- (2008) Kevin J. Pearson et al. Cell Metabolism
- Linking sirtuins, IGF-I signaling, and starvation
- (2008) Valter D. Longo EXPERIMENTAL GERONTOLOGY
- Genomewide Screen for Negative Regulators of Sirtuin Activity in Saccharomyces cerevisiae Reveals 40 Loci and Links to Metabolism
- (2008) R. M. Raisner et al. GENETICS
- PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks
- (2008) Lindsey A. Baker et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9
- (2008) Min Wei et al. PLoS Genetics
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
- (2008) H. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functionally significant insulin-like growth factor I receptor mutations in centenarians
- (2008) Y. Suh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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