A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay

(2019) Pamela Dakik et al.   Oncotarget

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

(2016) Jorge Iván Castillo-Quan et al.   Cell Reports

Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic

(2016) Benjamin D. Levine et al.   Cell Reports

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Low-dose lithium uptake promotes longevity in humans and metazoans

(2011) Kim Zarse et al.   EUROPEAN JOURNAL OF NUTRITION

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Drosophila melanogasteras a model system for the evaluation of anti-aging compounds

(2010) Mahtab Jafari   FLY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Quantification of Food Intake in Drosophila

(2009) Richard Wong et al.   PLoS One

Valproic acid extends Caenorhabditis elegans lifespan

(2008) Kimberley Evason et al.   AGING CELL

Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

(2008) Katsuya Tanabe et al.   PLOS BIOLOGY