Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

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GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells

(2017) Ningning Yan et al.   EXPERIMENTAL CELL RESEARCH

Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study

(2017) Marta Riera-Borrull et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

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Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

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Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

(2017) Li Tan et al.   Stem Cell Reports

Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer

(2017) Peter McAnena et al.   Cancers

Mitochondrial metabolites extend lifespan

(2016) Robert J. Mishur et al.   AGING CELL

Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin

(2016) HIKARU WATARAI et al.   ANTICANCER RESEARCH

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

(2016) Hannah R. Bridges et al.   BMC BIOLOGY

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

(2016) Navdeep S. Chandel et al.   Cell Metabolism

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

(2016) Ryan J.O. Dowling et al.   Cell Metabolism

Metformin Improves Metabolic Memory in High Fat Diet (HFD)-induced Renal Dysfunction

(2016) Kulbhushan Tikoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies and Challenges in Clinical Trials Targeting Human Aging

(2016) John C. Newman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3

(2016) Sandeep Kumar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

(2016) Stepana Boukalova et al.   MOLECULAR CANCER THERAPEUTICS

The Aging Epigenome

(2016) Lauren N. Booth et al.   MOLECULAR CELL

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Metformin and cancer: Quo vadis et cui bono?

(2016) Javier A. Menendez et al.   Oncotarget

Epigenetics and aging

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Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

(2015) Samuel Genheden et al.   Expert Opinion on Drug Discovery

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

Histone Methylation Marks on Circulating Nucleosomes as Novel Blood-Based Biomarker in Colorectal Cancer

(2015) Ugur Gezer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

(2015) Bérénice A. Benayoun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

(2015) Takla Griss et al.   PLOS BIOLOGY

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts

(2015) Sílvia Cufí et al.   Oncotarget

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Histone methylation and aging: Lessons learned from model systems

(2014) Brenna S. McCauley et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

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(2013) Begoña Martin-Castillo et al.   CELL CYCLE

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

EZH2 Down-Regulation Exacerbates Lipid Accumulation and Inflammation in in Vitro and in Vivo NAFLD

(2013) Serena Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin)

(2012) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Cellular Responses to the Metal-Binding Properties of Metformin

(2012) L. Logie et al.   DIABETES

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes

(2012) Karolina Holm et al.   Molecular Oncology

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Metformin limits the tumourigenicity of iPS cells without affecting their pluripotency

(2012) Alejandro Vazquez-Martin et al.   Scientific Reports

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

(2011) T. Sengoku et al.   GENES & DEVELOPMENT

Histone methylation makes its mark on longevity

(2011) Shuo Han et al.   TRENDS IN CELL BIOLOGY

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease

(2010) Ugur Deligezer et al.   CLINICA CHIMICA ACTA

The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?

(2010) Thomas D Lockwood   EXPERT OPINION ON THERAPEUTIC TARGETS

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

(2010) S Heublein et al.   ONCOGENE

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology

(2009) B. Martin-Castillo et al.   ANNALS OF ONCOLOGY

How To Winnow Actives from Inactives:  Introducing Molecular Orthogonal Sparse Bigrams (MOSBs) and Multiclass Winnow

(2008) Florian Nigsch et al.   Journal of Chemical Information and Modeling

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

(2008) Yongkun Wei et al.   MOLECULAR CARCINOGENESIS

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL