标题
Ageing as a risk factor for ALS/FTD
作者
关键词
-
出版物
HUMAN MOLECULAR GENETICS
Volume 26, Issue R2, Pages R105-R113
出版商
Oxford University Press (OUP)
发表日期
2017-07-04
DOI
10.1093/hmg/ddx247
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms
- (2017) Andrea Markovinovic et al. PROGRESS IN NEUROBIOLOGY
- Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes
- (2017) Herve Rhinn et al. Cell Systems
- Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD
- (2016) Alice Goode et al. Autophagy
- Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases
- (2016) John Hardy BIOCHEMICAL SOCIETY TRANSACTIONS
- UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
- (2016) Roland Hjerpe et al. CELL
- Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
- (2016) Wouter van Rheenen et al. NATURE GENETICS
- Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
- (2016) Ian T.S. Coyle-Gilchrist et al. NEUROLOGY
- Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System
- (2016) Fernando J. Martinez et al. NEURON
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nup100 regulatesSaccharomyces cerevisiaereplicative life span by mediating the nuclear export of specific tRNAs
- (2016) Christopher L. Lord et al. RNA
- Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
- (2016) H. Broder Schmidt et al. TRENDS IN BIOCHEMICAL SCIENCES
- Human TBK1: A Gatekeeper of Neuroinflammation
- (2016) Liyana Ahmad et al. TRENDS IN MOLECULAR MEDICINE
- Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
- (2016) Steven Boeynaems et al. Scientific Reports
- Global genome splicing analysis reveals an increased number of alternatively spliced genes with aging
- (2015) Sofía A. Rodríguez et al. AGING CELL
- Inflammatory molecules in Frontotemporal Dementia: Cerebrospinal fluid signature of progranulin mutation carriers
- (2015) D. Galimberti et al. BRAIN BEHAVIOR AND IMMUNITY
- Autophagy and neurodegeneration
- (2015) Rebecca A. Frake et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapamycin alleviates pathogenesis of a newDrosophilamodel of ALS-TDP
- (2015) Ching-Wei Cheng et al. JOURNAL OF NEUROGENETICS
- Frontotemporal dementia
- (2015) Jee Bang et al. LANCET
- The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
- (2015) Ke Zhang et al. NATURE
- GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
- (2015) Brian D. Freibaum et al. NATURE
- Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
- (2015) Axel Freischmidt et al. NATURE NEUROSCIENCE
- Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
- (2015) Ana Jovičić et al. NATURE NEUROSCIENCE
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
- (2015) E. T. Cirulli et al. SCIENCE
- Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
- (2014) Julie van der Zee et al. ACTA NEUROPATHOLOGICA
- Frontotemporal dementia: a bridge between dementia and neuromuscular disease
- (2014) Adeline S.L. Ng et al. Annals of the New York Academy of Sciences
- Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
- (2014) Anne Simonsen et al. Autophagy
- Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis
- (2014) Mayuko Osaka et al. HUMAN MOLECULAR GENETICS
- Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis
- (2014) Hannah M. Kaneb et al. HUMAN MOLECULAR GENETICS
- Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
- (2014) Ammar Al-Chalabi et al. LANCET NEUROLOGY
- Age-Related Incidence and Family History in Frontotemporal Dementia: Data from the Swedish Dementia Registry
- (2014) Christer Nilsson et al. PLoS One
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
- (2013) I. Fogh et al. HUMAN MOLECULAR GENETICS
- Inflammation in neurodegenerative diseases - an update
- (2013) Sandra Amor et al. IMMUNOLOGY
- Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
- (2013) Guo Zhang et al. NATURE
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels
- (2013) Fernando Bartolome et al. NEURON
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- Alzheimer’s Disease: Analyzing the Missing Heritability
- (2013) Perry G. Ridge et al. PLoS One
- Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
- (2012) Julien Couthouis et al. HUMAN MOLECULAR GENETICS
- The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function
- (2012) Owen A. Brady et al. HUMAN MOLECULAR GENETICS
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
- (2012) Clotilde Lagier-Tourenne et al. NATURE NEUROSCIENCE
- SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2012) E. Rubino et al. NEUROLOGY
- Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain
- (2012) J. N. Savas et al. SCIENCE
- Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
- (2012) Boris Rogelj et al. Scientific Reports
- Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
- (2011) Katya Rascovsky et al. BRAIN
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- The Role of Immune and Inflammatory Mechanisms in ALS
- (2011) P. A. McCombe et al. CURRENT MOLECULAR MEDICINE
- Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
- (2011) J. R. Tollervey et al. GENOME RESEARCH
- The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study
- (2011) Julie Phukan et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Classification of primary progressive aphasia and its variants
- (2011) M. L. Gorno-Tempini et al. NEUROLOGY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging
- (2010) Zeshan Ahmed et al. AMERICAN JOURNAL OF PATHOLOGY
- VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
- (2010) Emilie Tresse et al. Autophagy
- Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration
- (2010) Agnes L. Nishimura et al. BRAIN
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Relationship between neuropathology and disease progression in the SOD1G93A ALS mouse
- (2010) Wendy W. Yang et al. EXPERIMENTAL NEUROLOGY
- De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis
- (2010) Mariely DeJesus-Hernandez et al. HUMAN MUTATION
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
- (2009) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells
- (2009) Maximiliano A. D'Angelo et al. CELL
- Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population-based study
- (2009) A. Alonso et al. EUROPEAN JOURNAL OF NEUROLOGY
- Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
- (2009) Jeong-Sun Ju et al. JOURNAL OF CELL BIOLOGY
- Incidence of amyotrophic lateral sclerosis in Europe
- (2009) G. Logroscino et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Nuclear Contour Irregularity and Abnormal Transporter Protein Distribution in Anterior Horn Cells in Amyotrophic Lateral Sclerosis
- (2009) Yoshimi Kinoshita et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
- (2008) Xibin Liang et al. ANNALS OF NEUROLOGY
- Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes
- (2008) C. R. Brown et al. GENES & DEVELOPMENT
- Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
- (2008) Cong Zhang et al. NATURE MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started