标题
Metabolic Plasticity in Chemotherapy Resistance
作者
关键词
-
出版物
Frontiers in Oncology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-03-06
DOI
10.3389/fonc.2020.00281
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
- (2019) Edith Emmings et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells
- (2019) Petra Jagust et al. Frontiers in Pharmacology
- Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses
- (2019) Ivana Kurelac et al. Nature Communications
- Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
- (2019) Dongya Jia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer
- (2019) Wanming He et al. ONCOGENE
- Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition
- (2019) Alberto Cruz-Bermúdez et al. FREE RADICAL BIOLOGY AND MEDICINE
- PGC-1α Controls Mitochondrial Biogenesis in Drug-Resistant Colorectal Cancer Cells by Regulating Endoplasmic Reticulum Stress
- (2019) Chul Won Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Therapy resistance mediated by exosomes
- (2019) Teresa Bernadette Steinbichler et al. Molecular Cancer
- B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2
- (2019) Tongguo Shi et al. Cell Death & Disease
- Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer
- (2019) Giovanni L. Beretta et al. Frontiers in Chemistry
- NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer
- (2019) Jinrong Zhu et al. EBioMedicine
- Mitophagy in Cancer: A Tale of Adaptation
- (2019) Vara-Perez et al. Cells
- Mitochondrial Involvement in Cisplatin Resistance
- (2019) Veronica Cocetta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Progress in therapeutic strategies based on cancer lipid metabolism
- (2019) Xia‐Yao Diao et al. Thoracic Cancer
- Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer
- (2019) Diane M. Demas et al. Frontiers in Oncology
- Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
- (2019) Hao Wu et al. EMBO Molecular Medicine
- Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
- (2019) Tiziana Tataranni et al. Oxidative Medicine and Cellular Longevity
- Metabolic heterogeneity confers differences in melanoma metastatic potential
- (2019) Alpaslan Tasdogan et al. NATURE
- Dual Role of Mitophagy in Cancer Drug Resistance
- (2018) ANTICANCER RESEARCH
- A New Perspective on the Heterogeneity of Cancer Glycolysis
- (2018) Michael L. Neugent et al. Biomolecules & Therapeutics
- Targeting Glutamine Metabolism for Cancer Treatment
- (2018) Yeon-Kyung Choi et al. Biomolecules & Therapeutics
- Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism
- (2018) Ramachandran Rashmi et al. CANCER RESEARCH
- Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
- (2018) Daniela Catanzaro et al. FITOTERAPIA
- The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model
- (2018) Efthymia Papaevangelou et al. INTERNATIONAL JOURNAL OF CANCER
- Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells
- (2018) Dauren Alimbetov et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells
- (2018) Yunjie Xu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Chemoresistance in ovarian cancer: exploiting cancer stem cell metabolism
- (2018) Shan-Shan Li et al. Journal of Gynecologic Oncology
- The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance
- (2018) Benjamin L Woolbright et al. MOLECULAR CANCER THERAPEUTICS
- Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
- (2018) Róisín M. Loftus et al. Nature Communications
- Cisplatin liposome and 6-amino nicotinamide combination to overcome drug resistance in ovarian cancer cells
- (2018) Daniela Catanzaro et al. Oncotarget
- Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States
- (2018) Dongya Jia et al. Cells
- Dropping in on lipid droplets: insights into cellular stress and cancer
- (2018) Peter Shyu et al. BIOSCIENCE REPORTS
- Association of tamoxifen resistance and lipid reprogramming in breast cancer
- (2018) Susanne Hultsch et al. BMC CANCER
- Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC)
- (2018) Yifan Kong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC
- (2018) Soohyun Lee et al. Scientific Reports
- Mitochondrial dynamics and metastasis
- (2018) Dario C. Altieri CELLULAR AND MOLECULAR LIFE SCIENCES
- The Influence of Metabolism on Drug Response in Cancer
- (2018) Esther A. Zaal et al. Frontiers in Oncology
- Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization
- (2017) Giulia Girolimetti et al. HUMAN MOLECULAR GENETICS
- Metabolic shifts in residual breast cancer drive tumor recurrence
- (2017) Kristina M. Havas et al. JOURNAL OF CLINICAL INVESTIGATION
- Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma
- (2017) Arvin M. Gouw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Interactions in the Tumor Microenvironment
- (2017) Costas A. Lyssiotis et al. TRENDS IN CELL BIOLOGY
- Amino-acid transporters in T-cell activation and differentiation
- (2017) Wenkai Ren et al. Cell Death & Disease
- Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor
- (2017) Young Shin Cho et al. ACS Medicinal Chemistry Letters
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
- Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxel-resistant human lung cancer cells to paclitaxel
- (2017) Hong Sun et al. Oncotarget
- Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer
- (2017) Ru Chen et al. Scientific Reports
- An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
- (2017) L. Tirinato et al. Stem Cells International
- The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts
- (2017) Xiaolei Shi et al. Science Advances
- Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer
- (2017) Flora Guerra et al. Frontiers in Oncology
- Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
- (2017) Sajad Dar et al. Scientific Reports
- Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor
- (2016) Shuhong Guan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
- (2016) R. Moschoi et al. BLOOD
- Hallmarks of cancer stem cell metabolism
- (2016) Patricia Sancho et al. BRITISH JOURNAL OF CANCER
- EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape
- (2016) S.-O. Lim et al. CANCER RESEARCH
- Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
- (2016) Camille Lehuédé et al. CANCER RESEARCH
- Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer
- (2016) D S Matassa et al. CELL DEATH AND DIFFERENTIATION
- Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
- (2016) Dan Y. Gui et al. Cell Metabolism
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Synergistic Anticancer Action of Lysosomal Membrane Permeabilization and Glycolysis Inhibition
- (2016) Milica Kosic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells
- (2016) Oliver D.K. Maddocks et al. MOLECULAR CELL
- Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential
- (2016) Larry L. Luchsinger et al. NATURE
- Targeting metastasis-initiating cells through the fatty acid receptor CD36
- (2016) Gloria Pascual et al. NATURE
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
- (2016) J. R. Mayers et al. SCIENCE
- Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties
- (2016) Valentina Izzo et al. TRENDS IN CELL BIOLOGY
- ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells
- (2016) Jianye Cai et al. Cell Death & Disease
- Glutaminase GLS1 Inhibitors as Potential Cancer Treatment
- (2016) Ahmed F. Abdel-Magid ACS Medicinal Chemistry Letters
- Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold
- (2016) Sarah C. Zimmermann et al. ACS Medicinal Chemistry Letters
- Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
- (2016) Javier Prieto et al. Nature Communications
- Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells
- (2016) Lian Chen et al. Oncotarget
- Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640
- (2016) Clayton S. Lewis et al. Oncotarget
- A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer
- (2016) Li Yang et al. Oncotarget
- MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
- (2016) Xiaoran Li et al. Oncotarget
- Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress
- (2016) Huaping Liu et al. Oncotarget
- Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
- (2016) Luigi Ippolito et al. Oncotarget
- Oncogenic regulation of tumor metabolic reprogramming
- (2016) Míriam Tarrado-Castellarnau et al. Oncotarget
- Altered glutamine metabolism in platinum resistant ovarian cancer
- (2016) Chantelle D. Hudson et al. Oncotarget
- The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I
- (2016) Chia-Yi Su et al. Scientific Reports
- ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
- (2016) Sunghee Park et al. Cell Reports
- Lipid metabolic reprogramming in cancer cells
- (2016) S Beloribi-Djefaflia et al. Oncogenesis
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Metabolic Imaging in Prostate Cancer: Where We Are
- (2016) Claudia Testa et al. Frontiers in Oncology
- A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission
- (2015) Jing Zhou et al. Autophagy
- Tamoxifen regulation of sphingolipid metabolism—Therapeutic implications
- (2015) Samy A.F. Morad et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias
- (2015) M. R. Ricciardi et al. BLOOD
- Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
- (2015) Colin A. Flaveny et al. CANCER CELL
- c-Myc Alterations Confer Therapeutic Response and Acquired Resistance to c-Met Inhibitors in MET-Addicted Cancers
- (2015) Aijun Shen et al. CANCER RESEARCH
- Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
- (2015) Lucas B. Sullivan et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
- (2015) Patricia Sancho et al. Cell Metabolism
- Acetyl Coenzyme A: A Central Metabolite and Second Messenger
- (2015) Federico Pietrocola et al. Cell Metabolism
- AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow
- (2015) Yusuke Saito et al. Cell Stem Cell
- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
- (2015) Zhaoyong Li et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
- (2015) T. T. Vellinga et al. CLINICAL CANCER RESEARCH
- Autophagy in malignant transformation and cancer progression
- (2015) L. Galluzzi et al. EMBO JOURNAL
- MicroRNA-124 Reduces the Pentose Phosphate Pathway and Proliferation by Targeting PRPS1 and RPIA mRNAs in Human Colorectal Cancer Cells
- (2015) Zhaoping Qiu et al. GASTROENTEROLOGY
- Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells
- (2015) Ulf D. Kahlert et al. INTERNATIONAL JOURNAL OF CANCER
- Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression
- (2015) Julie V. Philley et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
- (2015) Yan Xiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
- (2015) Jagadish C. Ghosh et al. JNCI-Journal of the National Cancer Institute
- Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
- (2015) Jenny E Hernandez-Davies et al. Journal of Translational Medicine
- Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression
- (2015) R. S. Schrecengost et al. MOLECULAR CANCER RESEARCH
- Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors
- (2015) Madhavika N. Serasinghe et al. MOLECULAR CELL
- Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth
- (2015) Jennifer A. Kashatus et al. MOLECULAR CELL
- Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
- (2015) Franziska Baenke et al. Molecular Oncology
- p53 in survival, death and metabolic health: a lifeguard with a licence to kill
- (2015) Flore Kruiswijk et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
- (2015) Jade Mims et al. RADIATION RESEARCH
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Apoptotic effects of salinomycin on human ovarian cancer cell line (OVCAR-3)
- (2015) Fuat Kaplan et al. TUMOR BIOLOGY
- Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
- (2015) Daniela Catanzaro et al. Oncotarget
- Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer
- (2015) Caifeng Xie et al. Oncotarget
- High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant
- (2015) Gillian Farnie et al. Oncotarget
- 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits
- (2015) Corti Denise et al. Oncotarget
- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
- (2015) Jagadish C. Ghosh et al. JNCI-Journal of the National Cancer Institute
- Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
- (2015) Dorota Klysz et al. Science Signaling
- Stress Responses from the Endoplasmic Reticulum in Cancer
- (2015) Hironori Kato et al. Frontiers in Oncology
- Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?
- (2015) Oncotarget
- Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer
- (2015) Zachary C. Dobbin et al. Oncotarget
- Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors
- (2015) Ayesha B. Alvero et al. Oncotarget
- Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation
- (2015) Anna Pastò et al. Oncotarget
- Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma
- (2014) J. Kummetha Venkata et al. BLOOD
- Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix
- (2014) Céline Pinheiro et al. BMC CANCER
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- Ovarian tumor-initiating cells display a flexible metabolism
- (2014) Angela S. Anderson et al. EXPERIMENTAL CELL RESEARCH
- Azithromycin enhances the favorable results of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer
- (2014) D.J. Chu et al. GENETICS AND MOLECULAR RESEARCH
- Glutamate enrichment as new diagnostic opportunity in breast cancer
- (2014) Jan Budczies et al. INTERNATIONAL JOURNAL OF CANCER
- Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
- (2014) Jeong-Won Lee et al. INTERNATIONAL JOURNAL OF CANCER
- Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma
- (2014) Jonathan F. Bean et al. JOURNAL OF PEDIATRIC SURGERY
- Cholesterol depletion by methyl-β-cyclodextrin augments tamoxifen induced cell death by enhancing its uptake in melanoma
- (2014) Naoshad Mohammad et al. Molecular Cancer
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer
- (2014) I. R. Schlaepfer et al. MOLECULAR CANCER THERAPEUTICS
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
- (2014) L. Yang et al. Molecular Systems Biology
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- The Inhibitory Effect of Doxycycline on Cisplatin-Sensitive and -Resistant Epithelial Ovarian Cancer
- (2014) Wei Wu et al. PLoS One
- Bioenergetic Analysis of Ovarian Cancer Cell Lines: Profiling of Histological Subtypes and Identification of a Mitochondria-Defective Cell Line
- (2014) Usawadee Dier et al. PLoS One
- Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation
- (2014) Y. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene
- (2014) Cheryl K. Zogg Journal of Oncology
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Adipose tissue and adipocytes support tumorigenesis and metastasis
- (2013) Kristin M. Nieman et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Association of decreased mitochondrial DNA content with the progression of colorectal cancer
- (2013) HaiHong Cui et al. BMC CANCER
- LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
- (2013) David B. Shackelford et al. CANCER CELL
- Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
- (2013) Rizwan Haq et al. CANCER CELL
- An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
- (2013) K. J. Williams et al. CANCER RESEARCH
- Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model
- (2013) N Sanchez-Macedo et al. CELL DEATH AND DIFFERENTIATION
- On the future of mass-spectrometry-based lipidomics
- (2013) Ursula Loizides-Mangold FEBS Journal
- Membrane lipid saturation activates IRE1α without inducing clustering
- (2013) Yuto Kitai et al. GENES TO CELLS
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
- (2013) Z. Husain et al. JOURNAL OF IMMUNOLOGY
- Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force
- (2013) F. Polet et al. JOURNAL OF INTERNAL MEDICINE
- Tumor glycolysis as a target for cancer therapy: progress and prospects
- (2013) Shanmugasundaram Ganapathy-Kanniappan et al. Molecular Cancer
- TOFA suppresses ovarian cancer cell growth in vitro and in vivo
- (2013) SHU LI et al. Molecular Medicine Reports
- Heterogeneity of tumor-induced gene expression changes in the human metabolic network
- (2013) Jie Hu et al. NATURE BIOTECHNOLOGY
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
- (2013) J B Tennakoon et al. ONCOGENE
- Reduced Mitochondrial DNA Content Associates with Poor Prognosis of Prostate Cancer in African American Men
- (2013) Shahriar Koochekpour et al. PLoS One
- Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer
- (2013) Kelly M. Kennedy et al. PLoS One
- Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
- (2013) R. Volmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling
- (2013) A. Kasahara et al. SCIENCE
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2
- (2013) A A Arbini et al. Oncogenesis
- Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research
- (2013) Nuzhat Ahmed et al. Frontiers in Oncology
- Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration
- (2012) Christine A. Caneba et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Sphingosine 1-phosphate signalling in cancer
- (2012) Nigel J. Pyne et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells
- (2012) Ying-Hui Ko et al. CANCER BIOLOGY & THERAPY
- ATP-Citrate Lyase: A Key Player in Cancer Metabolism
- (2012) N. Zaidi et al. CANCER RESEARCH
- The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism
- (2012) Arvand Haschemi et al. Cell Metabolism
- IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
- (2012) H. Yang et al. CLINICAL CANCER RESEARCH
- Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype
- (2012) Natalie E. Simpson et al. Epigenetics
- Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts
- (2012) Christian Fabian et al. FEBS Journal
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile
- (2012) Cátia V. Vaz et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage
- (2012) Yusuke Kageyama et al. JOURNAL OF CELL BIOLOGY
- Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
- (2012) I. Mylonis et al. JOURNAL OF CELL SCIENCE
- Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance
- (2012) Flora Guerra et al. JOURNAL OF CLINICAL ONCOLOGY
- Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors
- (2012) Krupa Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- Ceramide-Antiestrogen Nanoliposomal Combinations--Novel Impact of Hormonal Therapy in Hormone-Insensitive Breast Cancer
- (2012) S. A. F. Morad et al. MOLECULAR CANCER THERAPEUTICS
- Dibenzophenanthridines as Inhibitors of Glutaminase C and Cancer Cell Proliferation
- (2012) William P. Katt et al. MOLECULAR CANCER THERAPEUTICS
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations
- (2012) Z Yao et al. ONCOGENE
- Metabolism-Related Proteins Are Differentially Expressed according to the Molecular Subtype of Invasive Breast Cancer Defined by Surrogate Immunohistochemistry
- (2012) Junjeong Choi et al. PATHOBIOLOGY
- Mesenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations
- (2012) Young Min Cho et al. PLoS One
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- PTEN in cancer, metabolism, and aging
- (2012) Ana Ortega-Molina et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer
- (2012) C C Cook et al. Cell Death & Disease
- Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures
- (2012) Daniel K Chan et al. Journal of Ovarian Research
- Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
- (2011) Sophia Y. Lunt et al. Annual Review of Cell and Developmental Biology
- Cancer-associated adipocytes promotes breast tumor radioresistance
- (2011) Ludivine Bochet et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The awakening of an advanced malignant cancer: An insult to the mitochondrial genome
- (2011) Cody C. Cook et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression
- (2011) Natalie E. Simpson et al. BREAST CANCER RESEARCH AND TREATMENT
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells
- (2011) Y.-Y. Liu et al. CANCER RESEARCH
- p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2
- (2011) T. Contractor et al. CANCER RESEARCH
- Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
- (2011) Y. Zhao et al. CANCER RESEARCH
- A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function
- (2011) G. Gasparre et al. CANCER RESEARCH
- Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion
- (2011) B. Dirat et al. CANCER RESEARCH
- The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
- (2011) Stephanos Pavlides et al. CELL CYCLE
- Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo
- (2011) Joseph L. Sottnik et al. CLINICAL & EXPERIMENTAL METASTASIS
- Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
- (2011) G. Z. Rocha et al. CLINICAL CANCER RESEARCH
- “Metabolic Reprogramming” in Ovarian Cancer Cells Resistant to Cisplatin
- (2011) M. Montopoli et al. CURRENT CANCER DRUG TARGETS
- The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
- (2011) Charles E Massie et al. EMBO JOURNAL
- CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction
- (2011) Alvin J. X. Lee et al. JOURNAL OF PATHOLOGY
- Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration
- (2011) P. Gao et al. MOLECULAR CANCER RESEARCH
- Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells
- (2011) W.-C. Huang et al. MOLECULAR CANCER RESEARCH
- Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
- (2011) J.-H. Cheong et al. MOLECULAR CANCER THERAPEUTICS
- ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress
- (2011) Wissam Assaily et al. MOLECULAR CELL
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
- (2011) Peng Jiang et al. NATURE CELL BIOLOGY
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Somatic Mutations throughout the Entire Mitochondrial Genome Are Associated with Elevated PSA Levels in Prostate Cancer Patients
- (2010) Anita Kloss-Brandstätter et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Androgen stimulates glycolysis forde novolipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells
- (2010) Jong-Seok Moon et al. BIOCHEMICAL JOURNAL
- Early Detection of Recurrent Breast Cancer Using Metabolite Profiling
- (2010) V. M. Asiago et al. CANCER RESEARCH
- De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
- (2010) E. Rysman et al. CANCER RESEARCH
- Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice
- (2010) Hua-shan Shi et al. CANCER SCIENCE
- Ketones and lactate “fuel” tumor growth and metastasis
- (2010) Gloria Bonuccelli et al. CELL CYCLE
- Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640
- (2010) James W. Antoon et al. ENDOCRINOLOGY
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
- (2010) Suriyan Ponnusamy et al. Future Oncology
- Phenethyl Isothiocyanate Inhibits Oxidative Phosphorylation to Trigger Reactive Oxygen Species-mediated Death of Human Prostate Cancer Cells
- (2010) Dong Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
- (2010) Hiroyuki Ariyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy
- (2010) Thuc T. Le et al. JOURNAL OF LIPID RESEARCH
- Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
- (2010) Ming Zhou et al. Molecular Cancer
- Targeting mitochondria for cancer therapy
- (2010) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland
- (2009) Anna M. Czarnecka et al. BREAST CANCER RESEARCH AND TREATMENT
- A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative Stress
- (2009) Danyi Li et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism
- (2009) I. Samudio et al. CANCER RESEARCH
- The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization
- (2009) Anna Maria Porcelli et al. HUMAN MOLECULAR GENETICS
- The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
- (2009) Junko Wakabayashi et al. JOURNAL OF CELL BIOLOGY
- Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
- (2009) Ismael Samudio et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma
- (2009) Steven O'Day et al. JOURNAL OF CLINICAL ONCOLOGY
- The Antitumor Effect and Hepatotoxicity of a Hexokinase II Inhibitor 3-Bromopyruvate: In Vivo Investigation of Intraarterial Administration in a Rabbit VX2 Hepatoma Model
- (2009) Hwan Jun Jae et al. KOREAN JOURNAL OF RADIOLOGY
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
- (2009) Naotada Ishihara et al. NATURE CELL BIOLOGY
- Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
- (2009) Y H Zhao et al. ONCOGENE
- EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
- (2009) D. Guo et al. Science Signaling
- Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
- (2008) S. Kitada et al. BLOOD
- The Warburg Effect in Leukemia-Stroma Cocultures Is Mediated by Mitochondrial Uncoupling Associated with Uncoupling Protein 2 Activation
- (2008) I. Samudio et al. CANCER RESEARCH
- Cancer Cell Metabolism: Warburg and Beyond
- (2008) Peggy P. Hsu et al. CELL
- Modulation of Drug Resistance in Ovarian Adenocarcinoma by Enhancing Intracellular Ceramide Using Tamoxifen-Loaded Biodegradable Polymeric Nanoparticles
- (2008) H. Devalapally et al. CLINICAL CANCER RESEARCH
- Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance
- (2008) Chun-Wun Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
- (2008) Pierre Sonveaux et al. JOURNAL OF CLINICAL INVESTIGATION
- Elesclomol induces cancer cell apoptosis through oxidative stress
- (2008) J. R. Kirshner et al. MOLECULAR CANCER THERAPEUTICS
- A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction
- (2008) H. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
- (2008) Vadivel Ganapathy et al. PHARMACOLOGY & THERAPEUTICS
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now