Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in mitochondrial function during EMT induced by TGFβ-1 in pancreatic cancer

(2017) Qingqu Guo   Oncology Letters

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

(2017) Ken Peeters et al.   Nature Communications

Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer

(2017) Venkatrao Vantaku et al.   Oncotarget

Implications of mitochondrial network organization in mitochondrial stress signalling in NARP cybrid and Rho0 cells

(2017) Jarosław Walczak et al.   Scientific Reports

Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory

(2017) Dongya Jia et al.   Cancers

Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors

(2017) Andrea Morandi et al.   Frontiers in Oncology

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism

(2017) Daniel C. Zielinski et al.   Scientific Reports

Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics

(2017) Aarash Bordbar et al.   Scientific Reports

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Nurture of Tumors Can Drive Their Metabolic Phenotype

(2016) Zachary T. Schug et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Oncometabolites: Unconventional triggers of oncogenic signalling cascades

(2016) Marco Sciacovelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis

(2016) J. C. Farris et al.   MOLECULAR CANCER RESEARCH

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Stability of the hybrid epithelial/mesenchymal phenotype

(2016) Mohit Kumar Jolly et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts

(2016) Alessandro Arcucci et al.   Biomed Research International

Mitochondrial DNA copy number variation across human cancers

(2016) Ed Reznik et al.   eLife

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

(2016) Hugh Colvin et al.   Scientific Reports

Mitochondrial Genetics Regulate Breast Cancer Tumorigenicity and Metastatic Potential

(2015) K. P. Feeley et al.   CANCER RESEARCH

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes

(2015) M. Robertson-Tessi et al.   CANCER RESEARCH

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Essential Role for Oxidative Phosphorylation in Cancer Progression

(2015) Maria Chiara Maiuri et al.   Cell Metabolism

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide

(2015) Venkat R. Pannala et al.   FREE RADICAL BIOLOGY AND MEDICINE

The complex crosstalk between mitochondria and the nucleus: What goes in between?

(2015) Umut Cagin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

(2015) Rebecca Lamb et al.   Oncotarget

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

(2015) Li Yang et al.   Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect

(2015) Chung-Ling Lu et al.   PLoS One

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Metabolic differences in breast cancer stem cells and differentiated progeny

(2014) Erina Vlashi et al.   BREAST CANCER RESEARCH AND TREATMENT

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

(2014) Caleb F. Davis et al.   CANCER CELL

AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis

(2014) Chih-Chien Chou et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

(2014) Yoav D. Shaul et al.   CELL

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration

(2014) J. B. Nunes et al.   HUMAN MOLECULAR GENETICS

Quantifying the underlying landscape and paths of cancer

(2014) C. Li et al.   Journal of the Royal Society Interface

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

(2014) L Jiang et al.   ONCOGENE

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers

(2014) A. M. Strohecker et al.   Cancer Discovery

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

(2014) Bryan G. Allen et al.   Redox Biology

Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies

(2014) Heather M. Wilkins et al.   Redox Biology

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

(2013) Lin Zhang et al.   BMC CANCER

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Crosstalk from Non-Cancerous Mitochondria Can Inhibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways

(2013) Benny Abraham Kaipparettu et al.   PLoS One

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

(2013) Luke Gammon et al.   PLoS One

MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accessorizing the human mitochondrial transcription machinery

(2013) Megan L. Bestwick et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

High Mitochondrial DNA Copy Number and Bioenergetic Function Are Associated with Tumor Invasion of Esophageal Squamous Cell Carcinoma Cell Lines

(2012) Chen-Sung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

(2012) S. Michal Jazwinski et al.   Frontiers in Physiology

Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties

(2011) Yi-Fang Tu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation

(2011) Rebeca Acin-Perez et al.   Cell Metabolism

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

(2011) Yunfei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer

(2011) Ren-Kui Bai et al.   Journal of Oncology

Comparing the yeast retrograde response and NF-κB stress responses: implications for aging

(2010) Visish Srinivasan et al.   AGING CELL

Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids

(2010) Benny Abraham Kaipparettu et al.   Annals of the New York Academy of Sciences

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

(2010) Muh-Hwa Yang et al.   CELL CYCLE

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolin-1−/− Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts

(2009) Federica Sotgia et al.   AMERICAN JOURNAL OF PATHOLOGY

SR/ER–mitochondrial local communication: Calcium and ROS

(2009) György Csordás et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice

(2009) Mariola Kulawiec et al.   JOURNAL OF HUMAN GENETICS

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Imagable 4T1 model for the study of late stage breast cancer

(2008) Kai Tao et al.   BMC CANCER

Performance of mitochondrial DNA mutations detecting early stage cancer

(2008) John P Jakupciak et al.   BMC CANCER

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial DNA variant interactions modify breast cancer risk

(2008) Daniel Covarrubias et al.   JOURNAL OF HUMAN GENETICS

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE