Sphingosine 1-phosphate signalling in cancer

FTY720 Analogues as Sphingosine Kinase 1 Inhibitors

(2011) Keng G. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants

(2010) Glyn Dawson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

(S)-FTY720-Vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity

(2010) William J. Valentine et al.   CELLULAR SIGNALLING

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function

(2010) Joanna M. Woodcock et al.   CELLULAR SIGNALLING

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

S1P1 and VEGFR-2 Form a Signaling Complex with Extracellularly Regulated Kinase 1/2 and Protein Kinase C-  Regulating ML-1 Thyroid Carcinoma Cell Migration

(2010) N. Bergelin et al.   ENDOCRINOLOGY

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

(2010) Jaclyn S. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

(2010) Carolyn Loveridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

(2010) T M Leclercq et al.   ONCOGENE

Targeted Disruption of the S1P2 Sphingosine 1-Phosphate Receptor Gene Leads to Diffuse Large B-Cell Lymphoma Formation

(2009) G. Cattoretti et al.   CANCER RESEARCH

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression Profiling the Temperature-Dependent Amphibian Response to Infection by Batrachochytrium dendrobatidis

(2009) Laia Ribas et al.   PLoS One

S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN

(2008) Enkhzol Malchinkhuu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells

(2008) Yasuo Nagaoka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

(2008) D. Pchejetski et al.   MOLECULAR CANCER THERAPEUTICS