Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma

Editorial [Hot Topic: Therapeutic Targeting of the Sphingolipid “Biostat” in Hematologic Malignancies (Guest Editors: Thomas P. Loughran and Hong-Gang Wang)]

(2012) Thomas P. Loughran et al.   Anti-Cancer Agents in Medicinal Chemistry

MYC addiction: a potential therapeutic target in MM

(2012) W. M. Kuehl et al.   BLOOD

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function

(2012) David García-Bernal et al.   JOURNAL OF PATHOLOGY

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases

(2012) Peng Gao et al.   PLoS One

Sphingolipids in cancer

(2011) Hideki Furuya et al.   CANCER AND METASTASIS REVIEWS

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

(2011) Vladimir Beljanski et al.   CANCER BIOLOGY & THERAPY

Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

(2011) James W. Antoon et al.   CANCER BIOLOGY & THERAPY

Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer

(2011) J. W. Antoon et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Multiple Myeloma

(2010) Jacob Laubach et al.   Annual Review of Medicine

S1P metabolism in cancer and other pathological conditions

(2010) Weng In Leong et al.   BIOCHIMIE

Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation

(2010) Ashley J. Snider et al.   BIOCHIMIE

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase

(2010) Alexander A. Chumanevich et al.   CARCINOGENESIS

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics

(2010) M.R. Pitman et al.   CURRENT CANCER DRUG TARGETS

Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640

(2010) James W. Antoon et al.   ENDOCRINOLOGY

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Therapeutic applications of bioactive sphingolipids in hematological malignancies

(2010) Huseyin Atakan Ekiz et al.   INTERNATIONAL JOURNAL OF CANCER

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

(2010) Patricia Gangoiti et al.   PROGRESS IN LIPID RESEARCH

Activation of Sphingosine Kinase-1 in Cancer: Implications for Therapeutic Targeting

(2010) Olivier Cuvillier et al.   Current Molecular Pharmacology

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

(2009) R. E. Tiedemann et al.   BLOOD

Sphingolipids in inflammation: pathological implications and potential therapeutic targets

(2009) Graeme F. Nixon   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis

(2008) Qing-Fang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

(2008) Stephanie Schwalm et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma

(2008) A. A. Morales et al.   BLOOD

Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1  during Hypoxia in Human Cancer Cells

(2008) I. Ader et al.   CANCER RESEARCH

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

(2008) Michael Maceyka et al.   JOURNAL OF LIPID RESEARCH

Sphingolipids: players in the pathology of metabolic disease

(2008) L. Ashley Cowart   TRENDS IN ENDOCRINOLOGY AND METABOLISM