标题
FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
作者
关键词
-
出版物
PHYSIOLOGICAL REVIEWS
Volume 99, Issue 3, Pages 1433-1466
出版商
American Physiological Society
发表日期
2019-05-08
DOI
10.1152/physrev.00029.2018
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Glutaminolysis is a metabolic dependency in FLT3ITDacute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
- (2018) Paolo Gallipoli et al. BLOOD
- Metabolic strugGLS after FLT3 inhibition in AML
- (2018) Samuel J. Taylor et al. BLOOD
- Effect of sorafenib on the outcomes of patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation
- (2018) Li Xuan et al. CANCER
- Irreversible modifications of receptor tyrosine kinases
- (2018) Matthew Kreitman et al. FEBS LETTERS
- Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia
- (2018) Anne Kresinsky et al. HAEMATOLOGICA
- GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
- (2018) Beibei Zhang et al. HAEMATOLOGICA
- MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin
- (2018) Katja Seipel et al. HAEMATOLOGICA
- Altered compensatory cytokine signaling underlies the discrepancy betweenFlt3–/–andFlt3l–/–mice
- (2018) Vivek Durai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia
- (2018) Yue Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Role of Bruton’s tyrosine kinase in B cells and malignancies
- (2018) Simar Pal Singh et al. Molecular Cancer
- Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia
- (2018) Noelia Puente-Moncada et al. MOLECULAR CANCER THERAPEUTICS
- Arsenic trioxide and sorafenib induce synthetic lethality of FLT3-ITD acute myeloid leukemia cells
- (2018) Rui Wang et al. MOLECULAR CANCER THERAPEUTICS
- Plasmacytoid dendritic cells: origin matters
- (2018) Markus G. Manz NATURE IMMUNOLOGY
- Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma
- (2018) Tianfeng Li et al. ONCOGENE
- ETV6/FLT3 fusion is a novel client protein of Hsp90
- (2018) Bui Thi Kim Ly et al. ONCOLOGY RESEARCH
- Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
- (2018) Lillian R. Klug et al. PHARMACOLOGY & THERAPEUTICS
- Defining the role of the RSK isoforms in cancer
- (2018) Thibault Houles et al. SEMINARS IN CANCER BIOLOGY
- FoxO transcription factors in cancer metabolism
- (2018) Raj Kumar Yadav et al. SEMINARS IN CANCER BIOLOGY
- De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia
- (2018) Axel Hyrenius-Wittsten et al. Nature Communications
- Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice
- (2018) Cyril Rivat et al. Nature Communications
- Distinct Metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood Acute Myeloid Leukemia
- (2018) Bradley Stockard et al. Scientific Reports
- Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia
- (2018) Anne Kresinsky et al. HAEMATOLOGICA
- GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells
- (2018) Beibei Zhang et al. HAEMATOLOGICA
- MDM2- and FLT3-inhibitors in the treatment of FLT3-ITD acute myeloid leukemia, specificity and efficacy of NVP-HDM201 and midostaurin
- (2018) Katja Seipel et al. HAEMATOLOGICA
- Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking
- (2018) William Critchley et al. Cells
- Impact of FLT3-ITD length on prognosis of acute myeloid leukemia
- (2018) Song-Bai Liu et al. HAEMATOLOGICA
- Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3
- (2018) Kozo Nagai et al. Oncotarget
- Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma
- (2018) Osman Cen et al. mSphere
- FLT3 pathway is a potential therapeutic target for PRC2-mutated T-cell acute lymphoblastic leukemia
- (2018) Jingliao Zhang et al. BLOOD
- Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance
- (2018) Dilana Staudt et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion
- (2018) Mario Buono et al. Nature Communications
- The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis
- (2017) Panagiotis Tsapogas et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia
- (2017) K Reiter et al. LEUKEMIA
- Targeting FLT3 by chimeric antigen receptor T cells for the treatment of acute myeloid leukemia
- (2017) L Chen et al. LEUKEMIA
- Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia
- (2017) M Jawhar et al. LEUKEMIA
- DNA methylation dynamics in aging: how far are we from understanding the mechanisms?
- (2017) Fabio Ciccarone et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Inhibition of USP10 induces degradation of oncogenic FLT3
- (2017) Ellen L Weisberg et al. Nature Chemical Biology
- Single-cell whole exome and targeted sequencing in NPM1/FLT3 positive pediatric acute myeloid leukemia
- (2017) Christiane Walter et al. PEDIATRIC BLOOD & CANCER
- A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia
- (2017) Alfred Chung et al. Cancer Genetics
- FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway
- (2017) Keigo Okada et al. Oncotarget
- ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling
- (2017) Julhash U. Kazi et al. Oncotarget
- High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma
- (2017) Normann Steiner et al. PLoS One
- The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation
- (2017) Alissa Marhäll et al. Scientific Reports
- All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo
- (2016) H. S. Ma et al. BLOOD
- Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
- (2016) I. Z. Uras et al. BLOOD
- Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor
- (2016) Lauren Y. Lee et al. BLOOD
- The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
- (2016) Weiguo Zhang et al. CANCER RESEARCH
- FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
- (2016) Elie Traer et al. CANCER RESEARCH
- Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
- (2016) Ansar Karimian et al. DNA REPAIR
- Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice
- (2016) Lilly von Muenchow et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia
- (2016) Karen W. L. Yee et al. INVESTIGATIONAL NEW DRUGS
- Multiple routes of endocytic internalization of PDGFRβ contribute to PDGF-induced STAT3 signaling
- (2016) Kamil Jastrzębski et al. JOURNAL OF CELL SCIENCE
- Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses
- (2016) Colleen M. Lau et al. JOURNAL OF EXPERIMENTAL MEDICINE
- DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells
- (2016) M Wu et al. LEUKEMIA
- A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?
- (2016) E Troadec et al. LEUKEMIA
- Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia
- (2016) B M Richine et al. LEUKEMIA
- Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype
- (2016) T A Müller et al. LEUKEMIA
- Mechanisms of ephrin–Eph signalling in development, physiology and disease
- (2016) Artur Kania et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Glucocorticoid-Induced Proliferation in Untreated Pediatric Acute Myeloid Leukemic Blasts
- (2016) Kim Klein et al. PEDIATRIC BLOOD & CANCER
- Expression of GADS enhances FLT3-induced mitogenic signaling
- (2016) Rohit A. Chougule et al. Oncotarget
- Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling
- (2016) Sausan A. Moharram et al. Oncotarget
- FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia
- (2016) Albert Català et al. Oncotarget
- An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
- (2016) Sophie Lopez et al. Oncotarget
- FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia
- (2016) Rohit A. Chougule et al. Oncotarget
- A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2
- (2016) Susanne B. Breitkopf et al. Scientific Reports
- Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells
- (2016) Mariko Abe et al. PLoS One
- FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation
- (2015) T. Oellerich et al. BLOOD
- Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling
- (2015) Julhash U. Kazi et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- RTK SLAP DOWN: The emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling
- (2015) Leanne E. Wybenga-Groot et al. CELLULAR SIGNALLING
- Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia
- (2015) M.-P. Garcia-Cuellar et al. HAEMATOLOGICA
- The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells
- (2015) E Chang et al. LEUKEMIA
- Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo
- (2015) P Arreba-Tutusaus et al. LEUKEMIA
- Structure and function of Gab2 and its role in cancer (Review)
- (2015) CHEN-BO DING et al. Molecular Medicine Reports
- CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
- (2015) Sarah Bertoli et al. Oncotarget
- Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia
- (2015) Genevra Pillinger et al. Scientific Reports
- Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia
- (2015) Pierre Sujobert et al. Cell Reports
- Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia
- (2015) M.-P. Garcia-Cuellar et al. HAEMATOLOGICA
- The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness
- (2015) Jing Zhang et al. Stem Cell Reports
- Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells
- (2015) Giacomo Volpe et al. PLoS One
- G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia
- (2014) H. K. Lee et al. BLOOD
- NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML
- (2014) S. Adamia et al. BLOOD
- SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia
- (2014) Alexandre Puissant et al. CANCER CELL
- SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
- (2014) Ling Li et al. Cell Stem Cell
- SOCS proteins in regulation of receptor tyrosine kinase signaling
- (2014) Julhash U. Kazi et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development
- (2014) P. Tsapogas et al. HAEMATOLOGICA
- Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival
- (2014) Y. Kikushige et al. JOURNAL OF IMMUNOLOGY
- UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor
- (2014) Weihe Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hes1 suppresses acute myeloid leukemia development through FLT3 repression
- (2014) T Kato et al. LEUKEMIA
- ETV6–FLT3 fusion gene-positive, eosinophilia-associated myeloproliferative neoplasm successfully treated with sorafenib and allogeneic stem cell transplant
- (2014) L Falchi et al. LEUKEMIA
- Clinical Targeting of Mutated and Wild-Type Protein Tyrosine Kinases in Cancer
- (2014) J. M. Drake et al. MOLECULAR AND CELLULAR BIOLOGY
- Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
- (2014) K. Keegan et al. MOLECULAR CANCER THERAPEUTICS
- Ubiquitination in disease pathogenesis and treatment
- (2014) Doris Popovic et al. NATURE MEDICINE
- The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V
- (2014) S Agarwal et al. ONCOGENE
- Regulation of Receptor Tyrosine Kinase Ligand Processing
- (2014) C. Adrain et al. Cold Spring Harbor Perspectives in Biology
- The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
- (2014) Amancio Carnero et al. Frontiers in Oncology
- Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia
- (2013) E. I. Zimmerman et al. BLOOD
- The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling
- (2013) Julhash U. Kazi et al. CELLULAR SIGNALLING
- Molecular Pathways: Mitogen-Activated Protein Kinase Pathway Mutations and Drug Resistance
- (2013) A. L. Pritchard et al. CLINICAL CANCER RESEARCH
- Phosphorylation of the Activation Loop Tyrosine 823 in c-Kit Is Crucial for Cell Survival and Proliferation
- (2013) Shruti Agarwal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells
- (2013) S. Kothe et al. JOURNAL OF CELL SCIENCE
- C/EBPα and MYB regulate FLT3 expression in AML
- (2013) G Volpe et al. LEUKEMIA
- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
- (2013) Linn Fagerberg et al. MOLECULAR & CELLULAR PROTEOMICS
- Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling
- (2013) Julhash U. Kazi et al. Molecular Oncology
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling
- (2013) Julhash U. Kazi et al. PLoS One
- Pim-1 Kinase Phosphorylates and Stabilizes 130 kDa FLT3 and Promotes Aberrant STAT5 Signaling in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication
- (2013) Karthika Natarajan et al. PLoS One
- Endocytosis of Receptor Tyrosine Kinases
- (2013) L. K. Goh et al. Cold Spring Harbor Perspectives in Biology
- Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases
- (2012) Bhopal Mohapatra et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia
- (2012) A. B. Williams et al. BLOOD
- SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control
- (2012) P. N. G. Reddy et al. BLOOD
- SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML
- (2012) H. Leischner et al. BLOOD
- Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3
- (2012) D.-C. Lin et al. BLOOD
- Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines
- (2012) Eystein Oveland et al. CELL BIOLOGY AND TOXICOLOGY
- Diversity of the juxtamembrane and TKD1 mutations (Exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological data
- (2012) Susanne Schnittger et al. GENES CHROMOSOMES & CANCER
- Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3
- (2012) Julhash U. Kazi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis
- (2012) B. Madan et al. JOURNAL OF IMMUNOLOGY
- The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
- (2012) S C Nabinger et al. LEUKEMIA
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
- (2012) Julhash U. Kazi et al. Molecular Oncology
- Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
- (2012) Catherine C. Smith et al. NATURE
- Role of the adaptor protein LNK in normal and malignant hematopoiesis
- (2012) S Gery et al. ONCOGENE
- Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications
- (2012) Johan Lennartsson et al. PHYSIOLOGICAL REVIEWS
- Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD
- (2011) Elena Razumovskaya et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Physical–chemical principles underlying RTK activation, and their implications for human disease
- (2011) Lijuan He et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex
- (2011) K. Verstraete et al. BLOOD
- Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3
- (2011) C. Walz et al. BLOOD
- Differential roles of trans-phosphorylated EGFR, HER2, HER3 and RET as heterodimerisation partners of MET in lung cancer with MET amplification
- (2011) J Tanizaki et al. BRITISH JOURNAL OF CANCER
- FLT3-Mediated p38-MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis
- (2011) C. Desterke et al. CANCER RESEARCH
- Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
- (2011) Nuzhat N. Kabir et al. GENETICS AND MOLECULAR BIOLOGY
- c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway
- (2011) Gaku Oshikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif
- (2011) You-Tong Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling
- (2011) Deepika Arora et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
- (2011) Shinichiro Takahashi Journal of Hematology & Oncology
- Potent Activity of Ponatinib (AP24534) in Models of FLT3-Driven Acute Myeloid Leukemia and Other Hematologic Malignancies
- (2011) J. M. Gozgit et al. MOLECULAR CANCER THERAPEUTICS
- Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
- (2011) N Ånensen et al. ONCOGENE
- Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
- (2011) S Hart et al. Blood Cancer Journal
- Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling
- (2010) Chozhavendan Rathinam et al. CANCER CELL
- Plasma and cerebrospinal fluid pharmacokinetics of MP470 in non-human primates
- (2010) P. A. Baxter et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance
- (2010) J. P. DiNitto et al. JOURNAL OF BIOCHEMISTRY
- Hoxa9 Regulates Flt3 in Lymphohematopoietic Progenitors
- (2010) K. Gwin et al. JOURNAL OF IMMUNOLOGY
- Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation
- (2010) M Buchwald et al. LEUKEMIA
- FES kinases are required for oncogenic FLT3 signaling
- (2010) E Voisset et al. LEUKEMIA
- mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells
- (2010) Weina Chen et al. Molecular Cancer
- Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
- (2010) C. Eidenschenk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Degradation of Activated Protein Kinases by Ubiquitination
- (2009) Lu Zhimin et al. Annual Review of Biochemistry
- Strong oligomerization behavior of PDGFβ receptor transmembrane domain and its regulation by the juxtamembrane regions
- (2009) Joanne Oates et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
- (2009) S. Kayser et al. BLOOD
- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
- (2009) P. P. Zarrinkar et al. BLOOD
- Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment
- (2009) L. K. Swee et al. BLOOD
- KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
- (2009) Y. Shiotsu et al. BLOOD
- A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
- (2009) Kristina Masson et al. BRITISH JOURNAL OF HAEMATOLOGY
- CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
- (2009) C. Reindl et al. CLINICAL CANCER RESEARCH
- Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation
- (2009) Elena Razumovskaya et al. EXPERIMENTAL HEMATOLOGY
- The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction
- (2009) Jianmin Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ectodomain Shedding of FLT3 Ligand Is Mediated by TNF- Converting Enzyme
- (2009) K. Horiuchi et al. JOURNAL OF IMMUNOLOGY
- The proteasomal system
- (2009) Tobias Jung et al. MOLECULAR ASPECTS OF MEDICINE
- The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways
- (2009) Nick Carpino et al. MOLECULAR IMMUNOLOGY
- Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
- (2009) Masashi Sanada et al. NATURE
- Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
- (2009) Y. K. Lieu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In Vivo Analysis of Dendritic Cell Development and Homeostasis
- (2009) K. Liu et al. SCIENCE
- The Single Transmembrane Domains of Human Receptor Tyrosine Kinases Encode Self-Interactions
- (2009) C. Finger et al. Science Signaling
- FMS-like tyrosine kinase 3 interacts with the glucocorticoid receptor complex and affects glucocorticoid dependent signaling
- (2008) Abolfazl Asadi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mutation of C/EBP predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen
- (2008) M. S. Hasemann et al. BLOOD
- Requirement of c-Myb for p210BCR/ABL-dependent transformation of hematopoietic progenitors and leukemogenesis
- (2008) M. R. Lidonnici et al. BLOOD
- Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
- (2008) F. Breitenbuecher et al. BLOOD
- Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML
- (2008) A. Sallmyr et al. BLOOD
- Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591
- (2008) S. Vempati et al. CLINICAL CANCER RESEARCH
- Bioinformatic prediction and analysis of eukaryotic protein kinases in the rat genome
- (2008) Julhash U. Kazi et al. GENE
- Role of SHP2 for FLT3-dependent proliferation and transformation in 32D cells
- (2008) J P Müller et al. LEUKEMIA
- MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells
- (2008) Chie Nishioka et al. LEUKEMIA RESEARCH
- The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
- (2008) Claudia Waskow et al. NATURE IMMUNOLOGY
- The FoxO code
- (2008) D R Calnan et al. ONCOGENE
- Intra-Articular Fms-Like Tyrosine Kinase 3 Ligand Expression Is a Driving Force in Induction and Progression of Arthritis
- (2008) Mats Dehlin et al. PLoS One
- Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases
- (2008) X. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
- (2008) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of glycosylation on protein folding: A close look at thermodynamic stabilization
- (2008) D. Shental-Bechor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Src family kinases: Regulation of their activities, levels and identification of new pathways
- (2007) Evan Ingley BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
- (2007) Marie Dance et al. CELLULAR SIGNALLING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search