期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 215, 期 5, 页码 1417-1435出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20171784
关键词
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资金
- Howard Hughes Medical Institute
- US National Institutes of Health [F30DK108498, T32 AI007163-40, T32 CA 009621]
- US National Science Foundation [DGE-1143954]
The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in Flt3l(-/-) mice than in Flt3(-/-) mice. This has led to speculation that Flt3L binds to another receptor that also supports DC development. However, we found that Flt3L administration does not generate DCs in Flt3(-/-) mice, arguing against a second receptor. Instead, Flt3(-/-) DC progenitors matured in response to macrophage colony-stimulating factor (M-CSF) or stem cell factor, and deletion of Csf1r in Flt3(-/-) mice further reduced DC development, indicating that these cytokines could compensate for Flt3. Surprisingly, Flt3(-/-) DC progenitors displayed enhanced M-CSF signaling, suggesting that loss of Flt3 increased responsiveness to other cytokines. In agreement, deletion of Flt3 in Flt3l(-/-) mice paradoxically rescued their severe DC deficiency. Thus, multiple cytokines can support DC development, and the discrepancy between Flt3(-/-) and Flt3l(-/-) mice results from the increased sensitivity of Flt3(-/-) progenitors to these cytokines.
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