Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical Implications

Activation and Function of the mTORC1 Pathway in Mast Cells

(2014) M.-S. Kim et al.   JOURNAL OF IMMUNOLOGY

c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice

(2011) James Y. Lindsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Core-Binding Factor Acute Myeloid Leukemia

(2011) Nikhil A. Sangle et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

(2011) Y.-N. Lee et al.   BLOOD

Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand−dependent mast cell functions

(2011) Mia Chen et al.   EXPERIMENTAL HEMATOLOGY

MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia

(2011) Xiao-ning Gao et al.   LEUKEMIA RESEARCH

C-KIT Signaling Depends on Microphthalmia-Associated Transcription Factor for Effects on Cell Proliferation

(2011) Bengt Phung et al.   PLoS One

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

(2011) Y.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation D816V Alters the Internal Structure and Dynamics of c-KIT Receptor Cytoplasmic Region: Implications for Dimerization and Activation Mechanisms

(2011) Elodie Laine et al.   PLoS Computational Biology

Signaling of c-kit in dendritic cells influences adaptive immunity

(2010) Prabir Ray et al.   Annals of the New York Academy of Sciences

Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics

(2010) Scott E. Woodman et al.   BIOCHEMICAL PHARMACOLOGY

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells

(2010) S. Drube et al.   BLOOD

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity

(2010) Barbara Muciaccia et al.   HUMAN REPRODUCTION

Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors

(2010) Koelz   INTERNATIONAL JOURNAL OF ONCOLOGY

Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance

(2010) J. P. DiNitto et al.   JOURNAL OF BIOCHEMISTRY

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

(2010) Fahad Zadjali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling from the Human Melanocortin 1 Receptor to ERK1 and ERK2 Mitogen-Activated Protein Kinases Involves Transactivation of cKIT

(2010) Cecilia Herraiz et al.   MOLECULAR ENDOCRINOLOGY

Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene

(2010) Dominique Kobi et al.   Pigment Cell & Melanoma Research

Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives

(2010) Michel Arock et al.   Expert Review of Hematology

Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics

(2009) M. Humbert et al.   ALLERGY

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

MicroRNA-dependent regulation of cKit in cutaneous melanoma

(2009) O. Igoucheva et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Strong oligomerization behavior of PDGFβ receptor transmembrane domain and its regulation by the juxtamembrane regions

(2009) Joanne Oates et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease

(2009) S. R. Bandi et al.   BLOOD

Fps/Fes protein-tyrosine kinase regulates mast cell adhesion and migration downstream of Kit and β1 integrin receptors

(2009) Julie A. Smith et al.   CELLULAR SIGNALLING

The Role of MITF Phosphorylation Sites During Coat Color and Eye Development in Mice Analyzed by Bacterial Artificial Chromosome Transgene Rescue

(2009) G. L. Bauer et al.   GENETICS

The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction

(2009) Jianmin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Pediatric Mastocytosis Is a Clonal Disease Associated with D816V and Other Activating c-KIT Mutations

(2009) Christine Bodemer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Aberrant Localization of Oncogenic Kit Tyrosine Kinase Receptor Mutants Is Reversed on Specific Inhibitory Treatment

(2009) H. Bougherara et al.   MOLECULAR CANCER RESEARCH

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Stem cell factor induces HIF-1α at normoxia in hematopoietic cells

(2008) Malin Pedersen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mast cells and mastocytosis

(2008) D. D. Metcalfe   BLOOD

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells

(2008) A. S. McDaniel et al.   BLOOD

Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells

(2008) C. Simon et al.   BLOOD

Stem cell factor and interleukin-2/15 combine to enhance MAPK-mediated proliferation of human natural killer cells

(2008) D. M. Benson et al.   BLOOD

Hypoxia-inducible factor (HIF)-1  directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

(2008) Z.-B. Han et al.   CARCINOGENESIS

KIT associated intracellular tyrosines play an essential role in EpoR co-signaling

(2008) Li Hong et al.   CELLULAR SIGNALLING

The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit

(2008) M. Pedersen et al.   CELLULAR SIGNALLING

Protein scaffolds in MAP kinase signalling

(2008) Matthew D. Brown et al.   CELLULAR SIGNALLING

c-kit Is Required for Cardiomyocyte Terminal Differentiation

(2008) Ming Li et al.   CIRCULATION RESEARCH

KIT Mutations Induce Intracellular Retention and Activation of an Immature Form of the KIT Protein in Gastrointestinal Stromal Tumors

(2008) S. Tabone-Eglinger et al.   CLINICAL CANCER RESEARCH

A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis

(2008) Valter Agosti et al.   EXPERIMENTAL HEMATOLOGY

Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit

(2008) Jianmin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine Phosphatase α Regulates Stem Cell Factor-dependent c-Kit Activation and Migration of Mast Cells

(2008) Lionel A. Samayawardhena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

(2008) L L Remsing Rix et al.   LEUKEMIA

Target spectrum of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib

(2008) Oliver Hantschel et al.   LEUKEMIA & LYMPHOMA

Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma

(2008) Nandini Krishnamoorthy et al.   NATURE MEDICINE

Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration

(2008) Songhee Jeon et al.   Pigment Cell & Melanoma Research

Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury

(2007) Shafie S. Fazel et al.   FASEB JOURNAL