标题
Ubiquitination in disease pathogenesis and treatment
作者
关键词
-
出版物
NATURE MEDICINE
Volume 20, Issue 11, Pages 1242-1253
出版商
Springer Nature
发表日期
2014-11-07
DOI
10.1038/nm.3739
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
- (2014) Agne Kazlauskaite et al. BIOCHEMICAL JOURNAL
- Enhanced Protein Degradation by Branched Ubiquitin Chains
- (2014) Hermann-Josef Meyer et al. CELL
- Deciphering Functions of Branched Ubiquitin Chains
- (2014) Jaime López-Mosqueda et al. CELL
- Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs
- (2014) Daisuke Hashimoto et al. EUROPEAN JOURNAL OF CANCER
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses
- (2014) Qin Liang et al. Nature Chemical Biology
- Ubiquitin in inflammation: the right linkage makes all the difference
- (2014) Jacob E Corn et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Toward understanding ubiquitin-modifying enzymes: from pharmacological targeting to proteomics
- (2014) Jennie R. Lill et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms
- (2014) Y. Yang et al. Cancer Discovery
- Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
- (2014) A. Yang et al. Cancer Discovery
- USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15
- (2013) Nidhi Sharma et al. CELL CYCLE
- Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
- (2013) J. Y. Guo et al. GENES & DEVELOPMENT
- The Deubiquitylating Enzyme USP44 Counteracts the DNA Double-strand Break Response Mediated by the RNF8 and RNF168 Ubiquitin Ligases
- (2013) Anna Mosbech et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
- (2013) Anne Kathrin Müller-Rischart et al. MOLECULAR CELL
- 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
- (2013) Amélie Fradet-Turcotte et al. NATURE
- p53 status determines the role of autophagy in pancreatic tumour development
- (2013) Mathias T. Rosenfeldt et al. NATURE
- Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders
- (2013) Ruisheng Song et al. NATURE
- Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
- (2013) Molly C. Kottemann et al. NATURE
- The protease activity of the paracaspase MALT1 is controlled by monoubiquitination
- (2013) Christiane Pelzer et al. NATURE IMMUNOLOGY
- Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown
- (2013) Jeremiah J Frye et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
- (2013) J.-F. Trempe et al. SCIENCE
- PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
- (2013) Y. Chen et al. SCIENCE
- A Strategy for Modulation of Enzymes in the Ubiquitin System
- (2013) A. Ernst et al. SCIENCE
- A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease
- (2013) Donald E. Spratt et al. Nature Communications
- The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
- (2012) Hwan-Ching Tai et al. AMERICAN JOURNAL OF PATHOLOGY
- Genetic lessons learned from X-linked Mendelian susceptibility to mycobacterial diseases
- (2012) Jacinta Bustamante et al. Annals of the New York Academy of Sciences
- Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy
- (2012) Véronique Schaeffer et al. Autophagy
- Generation and physiological roles of linear ubiquitin chains
- (2012) Henning Walczak et al. BMC BIOLOGY
- A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
- (2012) Dharminder Chauhan et al. CANCER CELL
- RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
- (2012) Francesca Mattiroli et al. CELL
- Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme
- (2012) Céline Reverdy et al. CHEMISTRY & BIOLOGY
- Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy
- (2012) Q. Li et al. CLINICAL CANCER RESEARCH
- Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity
- (2012) Yuji Masuda et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Proteasome-dependent Activation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Is Essential for Autophagy Suppression and Muscle Remodeling Following Denervation
- (2012) Pham Nguyen Quy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy
- (2012) Shenhav Cohen et al. JOURNAL OF CELL BIOLOGY
- HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
- (2012) Angela M Sosin et al. Journal of Hematology & Oncology
- Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation
- (2012) Franziska Meier et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
- (2012) Sung Jin Kim et al. MOLECULAR CELL
- Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
- (2012) Jonathan N. Pruneda et al. MOLECULAR CELL
- The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
- (2012) Rune Busk Damgaard et al. MOLECULAR CELL
- Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
- (2012) Bertrand Boisson et al. NATURE IMMUNOLOGY
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting IAP proteins for therapeutic intervention in cancer
- (2012) Simone Fulda et al. NATURE REVIEWS DRUG DISCOVERY
- Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function
- (2012) Rachael Baker et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
- (2012) Hao Dou et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
- (2012) A. Dey et al. SCIENCE
- New Proteasome Inhibitors in Myeloma
- (2012) Panisinee Lawasut et al. Current Hematologic Malignancy Reports
- Skp2 is a Promising Therapeutic Target in Breast Cancer
- (2012) Zhiwei Wang et al. Frontiers in Oncology
- Mitophagy: A Complex Mechanism of Mitochondrial Removal
- (2011) Ivana Novak ANTIOXIDANTS & REDOX SIGNALING
- USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma
- (2011) Samuel A. Williams et al. CELL
- Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation
- (2011) Mariusz Karbowski et al. CURRENT OPINION IN CELL BIOLOGY
- The Immunoproteasome: An Emerging Therapeutic Target
- (2011) Wooin Lee et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome
- (2011) Rachel M Blundred et al. Expert Review of Clinical Immunology
- CYLD: a deubiquitination enzyme with multiple roles in cancer
- (2011) Ramin Massoumi Future Oncology
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Autophagy-deficient mice develop multiple liver tumors
- (2011) A. Takamura et al. GENES & DEVELOPMENT
- Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation
- (2011) Silvia Zucchelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- La déubiquitinase CYLD
- (2011) Marion Bonnet et al. M S-MEDECINE SCIENCES
- Inflammation meets cancer, with NF-κB as the matchmaker
- (2011) Yinon Ben-Neriah et al. NATURE IMMUNOLOGY
- Inhibition of proteasome deubiquitinating activity as a new cancer therapy
- (2011) Pádraig D'Arcy et al. NATURE MEDICINE
- The spatial and temporal organization of ubiquitin networks
- (2011) Caroline Grabbe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
- (2011) Domagoj Vucic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deubiquitinases in cancer: new functions and therapeutic options
- (2011) J M Fraile et al. ONCOGENE
- Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
- (2011) A. T. Sasaki et al. Science Signaling
- Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation
- (2010) Yipeng Wang et al. Autophagy
- E2s: structurally economical and functionally replete
- (2010) Dawn M. Wenzel et al. BIOCHEMICAL JOURNAL
- Classical and/or alternative NF- B pathway activation in multiple myeloma
- (2010) Y. N. Demchenko et al. BLOOD
- The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
- (2010) G. W. Xu et al. BLOOD
- Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)
- (2010) J. P. Schmid et al. BLOOD
- XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease
- (2010) R. A. Marsh et al. BLOOD
- Feedback Regulation of Ras Signaling by Rabex-5-Mediated Ubiquitination
- (2010) Lizhong Xu et al. CURRENT BIOLOGY
- Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance
- (2010) Verena Arndt et al. CURRENT BIOLOGY
- Ubiquitin networks in cancer
- (2010) Vladimir Kirkin et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway
- (2010) Mikael Altun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome
- (2010) M. Basler et al. JOURNAL OF IMMUNOLOGY
- Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
- (2010) Rebecca Lock et al. MOLECULAR BIOLOGY OF THE CELL
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
- (2010) Yaron Pereg et al. NATURE CELL BIOLOGY
- Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
- (2010) Lynn Bedford et al. NATURE REVIEWS DRUG DISCOVERY
- FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair
- (2010) T. Liu et al. SCIENCE
- Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
- (2009) Francisca E. Reyes-Turcu et al. Annual Review of Biochemistry
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
- (2009) Grant S. Stewart et al. CELL
- Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
- (2009) Simin Rahighi et al. CELL
- Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
- (2009) Yipeng Wang et al. HUMAN MOLECULAR GENETICS
- During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
- (2009) Shenhav Cohen et al. JOURNAL OF CELL BIOLOGY
- H-Ras is degraded by Wnt/ -catenin signaling via -TrCP-mediated polyubiquitylation
- (2009) S.-E. Kim et al. JOURNAL OF CELL SCIENCE
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- Targeting the ubiquitin system in cancer therapy
- (2009) Daniela Hoeller et al. NATURE
- A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
- (2009) Tony Muchamuel et al. NATURE MEDICINE
- Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo
- (2009) Julie Lagirand-Cantaloube et al. PLoS One
- The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
- (2009) P. Knipscheer et al. SCIENCE
- Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology
- (2008) Alan L. Schwartz et al. Annual Review of Pharmacology and Toxicology
- Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
- (2008) Deborah J. Kuhn et al. BLOOD
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
- (2008) Francesca Bernassola et al. CANCER CELL
- Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism
- (2008) Hon Kit Wong et al. HUMAN MOLECULAR GENETICS
- Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
- (2008) Min Sung Kim et al. HUMAN PATHOLOGY
- c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation
- (2008) Eugene Varfolomeev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins
- (2008) Marie W. Wooten et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice
- (2008) Jianjun Wang et al. JOURNAL OF CELL BIOLOGY
- cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination
- (2008) Mathieu J.M. Bertrand et al. MOLECULAR CELL
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- (2008) Andrea Williams et al. Nature Chemical Biology
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started