期刊
CELLULAR SIGNALLING
卷 27, 期 2, 页码 267-274出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.11.010
关键词
SLAP2; Cbl; Juxtamembrane; Regulation; Eph
类别
资金
- Canadian Institutes of Health Research [MOP-12859, MOP-106507]
- American Brain Tumor Association
SLAP (Src like adaptor protein) contains adjacent Src homology 3 (SH3) and Src homology 2 (SH2) domains closely related in sequence to that of cytoplasmic Src family tyrosine kinases. Expressed most abundantly in the immune system, SLAP function has been predominantly studied in the context of lymphocyte signaling, where it functions in the Cbl dependent downregulation of antigen receptor signaling. However, accumulating evidence suggests that SLAP plays a role in the regulation of a broad range of membrane receptors including members of the receptor tyrosine kinase (RTK) family. In this review we highlight the role of SLAP in the ubiquitin dependent regulation of type III RTKs PDGFR, CSF-1R, KIT and Flt3, as well as Eph family RTKs. SLAP appears to bind activated type III and Eph RTKs via a conserved autophosphorylated juxtamembrane tyrosine motif in an SH2-dependent manner, suggesting that SLAP is important in regulating RTK signaling. (C) 2014 Elsevier Inc. All rights reserved.
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