Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells

Secondary mutations as mediators of resistance to targeted therapy in leukemia

(2015) N. Daver et al.   BLOOD

FLT3 Tyrosine Kinase Inhibition as a Paradigm for Targeted Drug Development in Acute Myeloid Leukemia

(2015) Michael R. Grunwald et al.   SEMINARS IN HEMATOLOGY

The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells

(2014) D. Suzuki et al.   DEVELOPMENT

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

(2014) Margarida A. Santos et al.   NATURE

Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states

(2014) K. W. Overton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance

(2013) Michael R. Grunwald et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

(2011) H J M de Jonge et al.   LEUKEMIA

Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor

(2011) M A Rego et al.   ONCOGENE

BCR-ABL but Not JAK2 V617F Inhibits Erythropoiesis through the Ras Signal by Inducing p21CIP1/WAF1

(2010) Masahiro Tokunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3

(2009) S. Fukuda et al.   BLOOD

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

(2009) M Shimabe et al.   ONCOGENE

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

(2009) R. Majeti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence

(2008) Francesca Ficara et al.   Cell Stem Cell