期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 84, 期 -, 页码 2-10出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.07.045
关键词
Tolerance; Thymus; Selection; Dendritic cells; Thymic epithelial cells; Antigen presentation
资金
- NIH [R37 AI39560, PO1 AI35296]
- T32 training grant [T32 AI007313, T32 GM008244, T32 GM113846]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007313, R37AI039560, R01AI039560, P01AI035296] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008244, T32GM113846] Funding Source: NIH RePORTER
The development of a self-tolerant and effective T cell receptor repertoire is dependent on interactions coordinated by various antigen presenting cells (APC) within the thymus. T cell receptor-self-peptide-MHC interactions are essential for determining T cell fate, however different cytokine and co-stimulatory signals provided by the diverse APCs within the thymus are also critical. Here, we outline the different localization and functional capabilities of thymic APCs. We also discuss how these distinct APCs work collectively to facilitate the establishment of a diverse T cell receptor repertoire that is tolerant to an array of different self-antigens. (C) 2017 Elsevier Ltd. All rights reserved.
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