Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

(2015) Misty R. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

(2014) Yuxing Zhao et al.   DIABETOLOGIA

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

(2014) M. R. Bull et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes

(2013) J. Chee et al.   JOURNAL OF IMMUNOLOGY

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

(2013) Julie A. Spicer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

(2012) Kate L. Graham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Perforin is a critical physiologic regulator of T-cell activation

(2011) J. E. Lykens et al.   BLOOD

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

(2011) B. Krishnamurthy et al.   DIABETES

An indirect role for NK cells in a CD4+ T-cell-dependent mouse model of type I diabetes

(2011) Eveline Angstetra et al.   IMMUNOLOGY AND CELL BIOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses

(2011) E. Corse et al.   JOURNAL OF IMMUNOLOGY

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

(2011) J. Chee et al.   JOURNAL OF IMMUNOLOGY

The role of perforin and granzymes in diabetes

(2009) H E Thomas et al.   CELL DEATH AND DIFFERENTIATION

How Punctual Ablation of Regulatory T Cells Unleashes an Autoimmune Lesion within the Pancreatic Islets

(2009) Markus Feuerer et al.   IMMUNITY

In vivo effects of cytokines on pancreatic β-cells in models of type I diabetes dependent on CD4+ T lymphocytes

(2008) Eveline Angstetra et al.   IMMUNOLOGY AND CELL BIOLOGY