Article
Oncology
Christine Weissenborn, Sophie von Lenthe, Nicole Hinz, Stefanie Langwisch, Mandy Busse, Anne Schumacher, Ana C. Zenclussen, Stefan Fest
Summary: This study found that transient ablation of Tregs hindered the growth of neuroblastoma (NB), while the absence of Bregs had no effect on NB growth, providing important evidence for targeting Tregs as a potential therapy for this aggressive childhood tumor.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Prashant S. Giri, Ankit H. Bharti, Jyoti Kode, Rasheedunnisa Begum, Mitesh Dwivedi
Summary: This study suggests that Harmine and Kaempferol treated Tregs may control the proliferation and production of CD8+ and CD4(+) T-cells in GV patients, leading to melanocytes' survival and proliferation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xu Liu, Na Tian, Qianru Huang, Zhan Xu, Hao Cheng, Xinnan Liu, Dan Li, Rui Liang, Bin Li, Xueyu Dai
Summary: It has been found that hnRNPA1 plays a crucial role in regulating the function of regulatory T cells, and its absence can lead to impaired Treg function and reduced expression of FOXP3. This suggests that hnRNPA1 may regulate Treg function through multiple pathways.
Article
Oncology
Lin Yang, Qijie Zhao, Xing Wang, Chalermchai Pilapong, Yi Li, Jun Zou, Jing Jin, Jinfeng Rong
Summary: Tregs have the potential to predict prognosis and tumor deterioration in esophageal cancer (EC) patients. Through computational algorithms, we found that Tregs and macrophage infiltration levels can stratify EC patients into high-risk and low-risk immune subgroups, with significant differences in tumor development, biological processes, and gene expression patterns. The interaction between STAT3 and Foxp3 is a potential prognostic indicator for Tregs in EC. STAT3 and Foxp3 expression also accurately predict Tregs infiltration levels in EC patients.
Article
Oncology
Joseph R. Campbell, Bryan R. McDonald, Paul B. Mesko, Nathan O. Siemers, Priti B. Singh, Mark Selby, Tim W. Sproul, Alan J. Korman, Logan M. Vlach, Jeff Houser, Sharmila Sambanthamoorthy, Kai Lu, Sandra Hatcher, Jack Lohre, Renu Jain, Ruth Y. Lan
Summary: Research suggests that selectively depleting regulatory T cells using an anti-CCR8 antibody can enhance antitumor immune responses, whether used as a monotherapy or in combination with other immunotherapies.
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Siawosh K. Eskandari, Hazim Allos, Basmah S. Al Dulaijan, Gandolina Melhem, Ina Sulkaj, Juliano B. Alhaddad, Anis J. Saad, Christa Deban, Philip Chu, John Y. Choi, Branislav Kollar, Bohdan Pomahac, Leonardo V. Riella, Stefan P. Berger, Jan S. F. Sanders, Judy Lieberman, Li Li, Jamil R. Azzi
Summary: Regulatory T cells (T-regs) have shown promise as cellular therapy for various immune diseases, but their clinical efficacy is limited by poor in vivo homeostasis. In this study, inhibiting mTORC1 effectively reduced intracytoplasmic expression and functionality of GrB in host T-regs, leading to decreased apoptosis and improved stability and homeostasis of T-regs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Meenu Kalkal, Rubika Chauhan, Reva Sharan Thakur, Mrinalini Tiwari, Veena Pande, Jyoti Das
Summary: Regulatory B cells play a crucial role in immune protection during infection with malaria parasites by controlling inflammation and inhibiting parasite growth. Adoptive transfer of these cells can slow down parasite growth and enhance survival in infected animals.
Article
Virology
Abdurrahman Simsek, Muhammed A. Kizmaz, Eren Cagan, Fatma Dombaz, Gulcin Tezcan, Ali Asan, H. Ibrahim Demir, S. Haldun Bal, Digdem Y. Ermis, Asli G. Dilektasli, Esra Kazak, E. Halis Akalin, H. Barbaros Oral, Ferah Budak
Summary: This study investigated the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and found that CD39(+) Tregs increased with disease severity in adult patients, while they decreased in an age-dependent manner in juvenile patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Kyeong Choi, Charles E. Egwuagu
Summary: B lymphocytes play a central role in host immunity by orchestrating humoral immune responses and producing neutralizing antibodies. Recent recognition shows that B cells also help maintain peripheral tolerance and suppress autoimmune diseases, with rare populations of regulatory B cells producing anti-inflammatory cytokines. The newly discovered i35-Bregs can suppress autoimmune diseases by inducing infectious tolerance in conventional B cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Shilpi Giri, Heikrujam Thoihen Meitei, Sandip Ashok Sonar, Saumitra Shaligram, Girdhari Lal
Summary: CD8 (+) T cells have suppressive functions in various tissues and diseases. This study shows an efficient method to differentiate naive CD8 (+) T cells into regulatory CD8 (+) T cells, which can restore oral tolerance.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Immunology
Kim Ohl, Klaus Tenbrock
Summary: Oxidative stress plays a significant role in cellular damage in T cells of patients with systemic lupus erythematosus, with the NRF2/Keap1 pathway serving as a crucial antioxidant system. Activating NRF2 may be a potential therapeutic target in SLE, although tissue and cell specific differences in NRF2 expression pose challenges.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jia Wang, Sheng-Xiao Zhang, Jia-Song Chang, Ting Cheng, Xiao-Jing Jiang, Qin-Yi Su, Jia-Qi Zhang, Jing Luo, Xiao-Feng Li
Summary: This study investigated the status of CD4(+) Tregs and the effects of low-dose IL-2 therapy in patients with refractory rheumatoid arthritis (RA). The results showed that a decrease in the absolute number of CD4 Tregs, rather than an increase in Th17 cells, contributed to an imbalance and high disease activity. Low-dose IL-2 selectively increased CD4 Tregs and rebalanced the ratio of Th17 and CD4 Tregs, leading to symptom remission without side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pooja Mehta, Victoire Gouirand, Devi P. Boda, Jingxian Zhang, Sofia Gearty, Bahar Zirak, Margaret M. Lowe, Sean Clancy, Ian Boothby, Kelly M. Mahuron, Adam Fries, Matthew F. Krummel, Parminder Mankoo, Hsin-Wen Chang, Jared Liu, Joshua M. Moreau, Tiffany C. Scharschmidt, Adil Daud, Esther Kim, Isaac M. Neuhaus, Hobart W. Harris, Wilson Liao, Michael D. Rosenblum
Summary: The study identifies LAYN (layilin) as preferentially expressed on a subset of activated Tregs in human skin, with a role in facilitating Treg adhesion and limiting their suppressive capacity. This mechanism may influence Treg motility and immune regulation in nonlymphoid tissues, potentially guiding therapeutic strategies for immune modulation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chaman Saini, Leena Sapra, Asha Bhardwaj, Mohd Tarique, Alpana Sharma, Neena Khanna, V Ramesh, Poonam Puri, Rupesh K. Srivastava
Summary: This study found that IL-21 cytokine expression is significantly increased in patients with leprosy T1R, and IL-21 promotes the occurrence of inflammation by regulating the balance of Th17 and Treg cell populations.
Article
Computer Science, Information Systems
Jayasri Kotti, D. Nageswara Rao, T. Ramana, Huma Khan, Abdul Shareef Pallivalappil, Harish Kumar, Henry Kwame Atiglah
Summary: This paper investigates a photovoltaic system based on the modified P&O algorithm, aiming to improve the stability and efficiency of the system using two MPPT algorithms and a hybrid controller algorithm. The proposed system utilizes IoT-based sensors to transmit data to the cloud for remote monitoring and control.
WIRELESS COMMUNICATIONS & MOBILE COMPUTING
(2022)
Article
Economics
Ved Dilip Beloskar, S. V. D. Nageswara Rao
Summary: Investors have shown increasing interest in Socially Responsible Investments (SRI), especially during crisis periods like the COVID-19 pandemic. ESG performance has proved to be valuable for investors, providing downside protection and reducing return volatility during such crises.
ASIA-PACIFIC FINANCIAL MARKETS
(2023)
Review
Cell Biology
Naoshad Muhammad, Darksha Usmani, Mohammad Tarique, Huma Naz, Mohammad Ashraf, Ramesh Raliya, Shams Tabrez, Torki A. Zughaibi, Ahdab Alsaieedi, Israa J. Hakeem, Mohd Suhail
Summary: Natural products play a critical role in cancer treatment by interfering with cellular mechanisms. Consuming fruits and vegetables can reduce the risk of cancer. Despite the challenges in developing drugs from natural products, advanced technologies allow us to identify potential natural products and study their therapeutic efficacy.
Review
Oncology
Mohd Suhail, Sayed Sartaj Sohrab, Mohammad Amjad Kamal, Esam Ibraheem Azhar
Summary: Hepatitis C virus (HCV) is a major cause of liver disease and neurological disorders. The virus interacts with host cells, leading to oxidative stress, liver inflammation, and dysregulated signaling pathways. This results in the activation of cancer-causing genes and metabolic disturbances, leading to liver fibrosis and angiogenesis. In addition to liver-related complications, HCV infection is also associated with neurological disorders such as encephalopathy and inflammatory disorders. Understanding the relationship between HCV-induced liver cancer and neurological disorders is crucial for diagnosis, treatment, and improving the quality of life for infected individuals.
FRONTIERS IN ONCOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Shams Tabrez, Torki A. A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. U. Khan
Article
Multidisciplinary Sciences
Shams Tabrez, Nasimudeen R. Jabir, Torki A. Zughaibi, Mohd Suhail
Summary: This study aimed to evaluate the possible association of interleukin-18 (IL-18) promoter polymorphism with comorbid conditions of cardiovascular disease (CVD). The results showed a significant association between IL-18 gene locus rs1946519 and comorbid conditions of CVD, suggesting its potential as a prognostic marker for CVD and comorbidities.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wardah A. A. Alhoqail, Abdulaziz S. S. Alothaim, Mohd Suhail, Danish Iqbal, Mehnaz Kamal, Majid Mohammed Asmari, Azfar Jamal
Summary: This study effectively reports the influence of experimental incubation period on the sol-gel production of husk-like zinc oxide nanoparticles (ZNPs) and their anti-cancerous abilities. The surface morphology and diameter range of ZNPs were studied using SEM and TEM, respectively. The X-ray diffraction investigation showed that ZNPs had a pure wurtzite crystal structure. Prolonging the experimental incubation resulted in a relative drop in aspect ratio and a distinct blue-shift in the UV-visible spectrum. RBC lysis assay and MTT assay results indicated the innoxious nature and cytotoxicity of ZNPs against cancer cells. ZNPs may be useful in the treatment of cancer.
Article
Nutrition & Dietetics
Mohd Suhail, Mohd Rehan, Mohammad Tarique, Shams Tabrez, Amjad Husain, Torki A. Zughaibi
Summary: This study aims to investigate the inhibitory mechanism of catechin derivatives (EC, EGC, ECG, and EGCG) on NF-kappa B in pancreatic cancer. In silico and in vitro studies were conducted to explore the binding pose, interacting residues, and molecular interactions. The results show that the catechin derivatives act as covalent inhibitors with the p65 subunit of NF-kappa B and interact with other residues through non-bonding interactions and hydrogen bonds. In addition, EGCG effectively reduces cell growth and proliferation, induces apoptosis, and inhibits NF-kappa B activity in pancreatic cancer cell lines, suggesting its potential as a therapeutic alternative for pancreatic cancer treatment.
FRONTIERS IN NUTRITION
(2023)
Article
Surgery
Ali Turan, Lei Zhang, Mohammad Tarique, Vahap Ulker, Feyza Nur Arguc, Darshan Badal, Esma S. Yolcu, Haval Shirwan
Summary: This study generated a chimeric form of thrombomodulin with streptavidin (SATM), which was displayed on the surface of biotinylated islets to mitigate blood-mediated inflammatory reaction after intraportal transplantation. Islets engineered with SA-TM showed improved engraftment and function, and could potentially be used for autologous and allogeneic islet transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Iftikhar Ahmad, Mohd Suhail, Ausaf Ahmad, Mahmoud Alhosin, Shams Tabrez
Summary: Cancer and diabetes mellitus are major causes of death and illness worldwide. Recent studies have shown that diabetes may promote cancer, although the exact mechanisms behind this association are largely unknown. This review aims to explore and understand the possible mechanisms linking diabetes and cancer. Hyperglycemia is a possible explanation for carcinogenesis in diabetic patients, as high glucose levels can aid in cancer cell proliferation. Chronic inflammation, another well-known factor in diabetes, may also play a role in the development of cancer. Additionally, the medications used to treat diabetes can either increase or reduce the risk of cancer. Insulin, a potent growth factor, can directly promote cell propagation and induce cancer, while hyperinsulinemia can increase the activity of growth factor-1. To improve cancer prognosis, individuals with diabetes should be screened for cancer at an early stage and receive appropriate treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Immunology
Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A. Zughaibi, Tabish H. Khan, Neena Khanna, Alpana Sharma
Summary: The overexpression of PD-1 in various immune cells is associated with disease severity in leprosy. Inhibition of PD-1 can restore the immunosuppressive activity of Treg cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ayse Ece Gulen, Rakesh Rudraboina, Mohammad Tarique, Vahap Ulker, Haval Shirwan, Esma S. S. Yolcu
Summary: Immunotherapy utilizing checkpoint inhibitors has shown remarkable success in cancer treatment. This study investigates the potential of using a specific immune co-stimulatory receptor, CD137, to enhance immune activation and inhibit tumor growth. The researchers generated a soluble form of the CD137 ligand, which effectively inhibited the development of lung tumors in mice induced by a tobacco carcinogen. The study suggests that this immune co-stimulation approach can be extended to other cancer types.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mohd Suhail, Wejdan M. Alzahrani, Shazi Shakil, Mohammad Tarique, Shams Tabrez, Torki A. Zughaibi, Mohd Rehan
Summary: Cancer is one of the leading causes of death globally, but satisfactory treatment outcomes have not yet been achieved. Therefore, there is a high demand for the development of innovative, inexpensive, and effective anticancer treatments. Natural compounds with high molecular diversity and minimal side effects have been increasingly used in cancer therapy. Among the investigated natural flavonoids, flavopiridol showed the highest potential as an inhibitor of the PI3K gamma pathway, providing new insights into rational drug discovery research for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Business, Finance
Sree Vinutha Venkataraman, S. V. D. Nageswara Rao
Summary: The comparison of investments under the third-order stochastic dominance is essential, and a new method is proposed to test for third-order efficiency, finding several funds that are superior to benchmark indices.
INTERNATIONAL JOURNAL OF FINANCE & ECONOMICS
(2023)