Review
Immunology
Xiaoxue Ma, Shingo Nakayamada
Summary: T follicular helper (Tfh) cells participate in humoral immune responses by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation of autoantibodies. The plasticity of Tfh cells allows for adjustment of differentiation direction based on immune response level, regulated by various signaling factors such as cytokines, receptors, transcription factors, and genes. The STAT family signaling pathways play a crucial role in Tfh formation, with each member contributing to Tfh differentiation through mutual restraint and cooperation among cytokine-STAT signals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yosuke Kaneko, Shin-ichiro Ozawa, Yuiko Sato, Tami Kobayashi, Tatsuaki Matsumoto, Kana Miyamoto, Shu Kobayashi, Kengo Harato, Shuichi Hirono, Morio Matsumoto, Masaya Nakamura, Yasuo Niki, Takeshi Miyamoto
Summary: This study investigated the feasibility of inhibiting Stat3 activity as a treatment for rheumatoid arthritis. Through in silico screening, the researchers identified a compound, F0648-0027, that inhibited arthritis development and blocked Stat3 activation. These findings suggest that Stat3 may be a therapeutic target for collagen-induced arthritis, and F0648-0027 could serve as a potential treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Jian Lu, Jing Wu, Xueli Xia, Huiyong Peng, Shengjun Wang
Summary: RA is a chronic autoimmune disease characterized by joint and systemic inflammation, with Tfh cells playing a crucial role in the pathogenesis of the disease and affecting disease activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: The study found that IL-10 promotes fibrosis in endometriosis instead of having an anti-fibrotic effect. Inhibition of STAT3 gene activation can reduce the pro-fibrotic phenotype induced by IL-10 in endometriotic stromal cells.
HUMAN REPRODUCTION
(2023)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Katharine B. Moosic, Kusuma Ananth, Felipe Andrade, David J. Feith, Erika Darrah, Thomas P. Loughran
Summary: This review discusses the parallels and potential mechanisms between LGL leukemia and RA, suggesting that LGL may drive the development of RA. Further investigations are needed to better understand the relationship and develop targeted therapies for both disorders.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Snigdha Samarpita, Mahaboobkhan Rasool
Summary: The study demonstrated that cyanidin plays a crucial role in treating rheumatoid arthritis by regulating the balance of Th17/Treg and reducing pathogenic Tfh cells. Cyanidin inhibited the proliferation of Th17 cells, increased the number of Treg cells, and restored IL-10 secretion, which effectively improved disease symptoms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hahnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Summary: In early RA patients and individuals at risk for RA, there is an increase in Tfh cells in lymphoid tissues with decreased IL-21 production.
Review
Cell Biology
Andrew P. Hart, Terri M. Laufer
Summary: T follicular helper (Tfh) cells play a critical role in adaptive immunity, supporting germinal center B cell survival, antibody class switching, and plasma cell maturation. The differentiation of Tfh is regulated by signals and transcription factors, and further research is needed to understand the dysregulation of Tfh in autoimmune diseases.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Medicine, General & Internal
Rui Su, Yanyan Wang, Fangyuan Hu, Baochen Li, Qiaoling Guo, Xinyu Zheng, Yue Liu, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: Recent studies have suggested the involvement of Tfh and Tfr cells in the pathogenesis of rheumatoid arthritis. This study found elevated Tfh-like and PD-1(+) Tfh-like cells, decreased Treg, Tfr-like, and mTfr-like cells, and altered Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios in RA patients. The abnormal levels of Tfh-like cells and their subsets are closely related to B cells and the cytokines involved in RA pathogenesis.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Zhao-Ming Chen, Xiao-Yun Yang, Zheng-Tu Li, Wei-Jie Guan, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Zi-Ying Lei, Jing Liu, Jian-Quan Zhang, Zhong-Fang Wang, Feng Ye
Summary: The presence of anti-IFN-gamma autoantibodies inhibits immune responses of CD4(+) Th1 and CD8(+) T cells, and increases the release of IL-10.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, Research & Experimental
Jiameng Lu, Xiaoqing Ji, Lixia Wang, Fei Sun, Chuanjun Huang, Haiying Peng, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Yanbo Ji, Degan Lu
Summary: This study found that prophylactic administration of IL-27 can improve asthma by restoring the STAT1 and STAT3 pathways, alleviating the Th2 inflammatory environment in the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Allergy
Zhi-Chao Wang, Yin Yao, Cai-Ling Chen, Cui-Lian Guo, Hong-Xia Ding, Jia Song, Zhe-Zheng Wang, Nan Wang, Xue-Li Li, Bo Liao, Yang Yang, Di Yu, Zheng Liu
Summary: PD-1(high) CXCR5(-)CD4(+) T cells contribute to local immunoglobulin production independent of ectopic lymphoid tissues in nasal polyps.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Critical Care Medicine
Yin Yao, Ao Huang, Yi-Ke Deng, Yan Liu, Hong-Yu Zhu, Nan Wang, Zhe-Zheng Wang, Rong-Fei Zhu, Di Yu, Zheng Liu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Immunology
Zhian Chen, Naiqi Wang, Yin Yao, Di Yu
Summary: This article reviews recent advances in understanding the regulation of T-FH cell survival through cell death pathways that are closely connected with cellular metabolism. Such knowledge can be applied to guide strategies for modulating humoral immunity, including enhancing vaccine efficacy.
TRENDS IN IMMUNOLOGY
(2022)
Review
Immunology
Di Yu, Lucy S. K. Walker, Zheng Liu, Michelle A. Linterman, Zhanguo Li
Summary: Yu et al. review the crucial roles of follicular helper T cells in humoral immunity, including sustaining germinal center B cell responses, regulating antibody affinity maturation and memory formation, and mediating pathogenic autoimmune responses. Understanding the regulation of follicular helper T cell generation and function is important for disease prevention and treatment, as well as vaccine development and enhancement.
Review
Immunology
Xin Gao, Ian A. Cockburn
Summary: CD11c(+) T-bet(+) atypical B cells (ABCs) are a type of cells identified in the context of vaccination, infections, and autoimmune diseases. However, the origins and functions of ABCs remain unknown. Recent studies using single-cell RNA sequencing have accurately identified these cells and revealed their abundance in healthy individuals. Nonetheless, the normal function of these cells is still elusive.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joseph Yunis, Kirsty R. Short, Di Yu
Summary: Respiratory viral infections, such as SARS-CoV-2 and IAV, can lead to different outcomes based on the immune response and inflammation. T cells play a significant role in shaping both immunity and inflammation, and understanding the interactions between the host and pathogens can help prevent immune dysfunction and improve treatment strategies.
TRENDS IN MICROBIOLOGY
(2023)
Article
Biology
Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi H. O. Nguyen, Lilith F. Allen, Katherine Kedzierska, Yanliang Jin, Mei-Rong Du, Wanping Chen, Liangjing Lu, Nan Shen, Zheng Liu, Ian A. Cockburn, Wenjing Luo, Di Yu
Summary: A defining feature of successful vaccination is the induction of long-lived antigen-specific memory cells. This study reveals that Tfh17 cells play a key role in maintaining and enhancing humoral immune responses. The results from both mouse and human experiments suggest that Tfh17-induced immunization might be preferable for long-term protection in vaccine development.
Article
Immunology
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F. Canete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Siling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K. Wang, Yen-Hua Huang, Jonathan A. Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David Craik, Zheng Liu, Hai Qi, Christopher Parish, Di Yu
Summary: In antibody responses, mutated germinal center B (BGc) cells are positively selected for reentry or differentiation, with the support of TFH cell-derived signals including CD40 and IL-21. The binding and signaling of IL-21 in BGc cells is reduced compared to non-BGc cells, due to low cellular heparan sulfate (HS) sulfation. Ndst1-mediated N-sulfation of HS in B cells promotes IL-21 binding and signal strength, and selective desensitization to IL-21 occurs in BGc cells. Therefore, the biochemical regulation of IL-21 availability and signal strength plays a crucial role in GC selection.
SCIENCE IMMUNOLOGY
(2023)
Review
Immunology
Sam Nettelfield, Di Yu, Pablo F. Canete
Summary: Immunometabolism research has revealed the complex relationship between individual metabolism and vaccine responses, highlighting the significant impact of metabolic dysregulation on vaccine efficacy, especially in vulnerable populations. Studies have also identified the influence of micronutrients and metabolic hormones on vaccine outcomes, as well as the effect of systemic metabolism on vaccine responses.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Antczak, Pablo F. Canete, Zhian Chen, Clemence Belle, Di Yu
Summary: The common gamma chain family of cytokines and their receptors play important roles in the immune system. Evolutionary studies have revealed the unique nature of cytokine evolution, which involves positive selection pressure to adapt to rapidly evolving threats while maintaining receptor binding capabilities. This review summarizes the evolutionary mechanisms behind the diverse gamma chain cytokine family and discusses the benefits of studying cytokine evolution and current models of cytokine emergence. The challenges associated with studying rapidly evolving genes are also addressed, along with computational methods used to uncover aspects of cytokine evolution.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Nanoscience & Nanotechnology
Zhian Chen, Xin Gao, Di Yu
Summary: Vaccination is a significant achievement in modern medicine, and it is crucial for combating the COVID-19 pandemic. The duration of vaccine-induced protection varies among different vaccines, and understanding the immunological mechanisms underlying vaccine protection is essential for improving their longevity.