PD-L1hi B cells are critical regulators of humoral immunity

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

(2014) Martin Vaeth et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular targets of regulatory B cell-mediated suppression

(2014) Elizabeth C. Rosser et al.   MOLECULAR IMMUNOLOGY

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease

(2013) M. Wong et al.   JOURNAL OF IMMUNOLOGY

Myeloid Cells Limit Production of Antibody-Secreting Cells after Immunization in the Lymph Node

(2013) D. R. Fooksman et al.   JOURNAL OF IMMUNOLOGY

Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation

(2013) Koichi Yanaba et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

Serum levels of BAFF, but not APRIL, are increased after rituximab treatment in patients with primary Sjögren's syndrome: data from a placebo-controlled clinical trial

(2012) Rodney P E Pollard et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

IgA plasma cells express the negative regulatory co-stimulatory molecule programmed cell death 1 ligand and have a potential tolerogenic role in the intestine

(2012) Tomomitsu Doi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function

(2012) Roza I. Nurieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The origins, function, and regulation of T follicular helper cells

(2012) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

The role of the PD-1 pathway in autoimmunity and peripheral tolerance

(2011) Brian T. Fife et al.   Annals of the New York Academy of Sciences

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

(2011) M. H. Kaplan et al.   BLOOD

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Identification of the Synthetic CannabinoidR(+)WIN55,212-2 as a Novel Regulator of IFN Regulatory Factor 3 Activation and IFN-β Expression

(2011) Eric J. Downer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice

(2011) Mayuka Horikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells

(2011) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors

(2011) M. Kreuzaler et al.   JOURNAL OF IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

(2011) Pheh-Ping Chang et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease

(2010) S. Sarantopoulos et al.   BLOOD

Regulation of immunity and autoimmunity by B cells

(2010) Claudia Mauri   CURRENT OPINION IN IMMUNOLOGY

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis

(2010) Keith M. Hamel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation

(2010) Mark S. Wilson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model

(2010) Sylvie Amu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Signaling Pathways in T Follicular Helper Cells

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance

(2010) Hye-Jung Kim et al.   NATURE

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Plasma cells negatively regulate the follicular helper T cell program

(2010) Nadége Pelletier et al.   NATURE IMMUNOLOGY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

(2008) Cecile King et al.   Annual Review of Immunology

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE