Expanding antigen-specific regulatory networks to treat autoimmunity

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

(2014) Bronwen R. Burton et al.   Nature Communications

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

(2013) Samantha L. Bailey-Bucktrout et al.   IMMUNITY

Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection

(2013) J. Scott Hale et al.   IMMUNITY

Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells

(2013) Jianmei W. Leavenworth et al.   JOURNAL OF CLINICAL INVESTIGATION

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses

(2013) F. Spensieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Regulatory T-cell therapy is a safe and well-tolerated potential approach for treating refractory Crohn's disease

(2012) Andy McLarnon   Nature Reviews Gastroenterology & Hepatology

Clinical tolerance in allogeneic hematopoietic stem cell transplantation

(2011) Maria-Grazia Roncarolo et al.   IMMUNOLOGICAL REVIEWS

Marked Induction of c-Maf Protein during Th17 Cell Differentiation and Its Implication in Memory Th Cell Development

(2011) Kojiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Long and Winding Road to Understanding and Conquering Type 1 Diabetes

(2010) Pere Santamaria   IMMUNITY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope

(2008) Junbao Yang et al.   JOURNAL OF AUTOIMMUNITY