Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells

An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse

(2017) Timothy A. Wiles et al.   JOURNAL OF AUTOIMMUNITY

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

(2016) Sven Malchow et al.   IMMUNITY

Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells

(2016) Daniel S. Leventhal et al.   IMMUNITY

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

(2016) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Early signs of disease in type 1 diabetes

(2016) Robert Moulder et al.   PEDIATRIC DIABETES

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Targeting Treg signaling for the treatment of autoimmune diseases

(2015) Allyson Spence et al.   CURRENT OPINION IN IMMUNOLOGY

Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors

(2015) Nicolas Thiault et al.   NATURE IMMUNOLOGY

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes

(2014) J. W. McGinty et al.   DIABETES

TCR Affinity and Tolerance Mechanisms Converge To Shape T Cell Diabetogenic Potential

(2014) Maria Bettini et al.   JOURNAL OF IMMUNOLOGY

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

(2014) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice

(2013) K. E. Pauken et al.   JOURNAL OF IMMUNOLOGY

Generation of T cell receptor–retrogenic mice: improved retroviral-mediated stem cell gene transfer

(2013) Matthew L Bettini et al.   Nature Protocols

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

(2012) Matthew L. Bettini et al.   IMMUNITY

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope

(2011) Carolin Daniel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-Based Selection of Small Molecules To Alter Allele-Specific MHC Class II Antigen Presentation

(2011) A. W. Michels et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

(2011) F. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

(2011) Kai W. Wucherpfennig et al.   SEMINARS IN IMMUNOLOGY

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

(2010) S. Hanabuchi et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY