Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
出版年份 2019 全文链接
标题
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-02-13
DOI
10.1038/s41573-019-0016-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Tumor-Repopulating Cells Induce PD-1 Expression in CD8 + T Cells by Transferring Kynurenine and AhR Activation
- (2018) Yuying Liu et al. CANCER CELL
- A patent review of IDO1 inhibitors for cancer
- (2018) Jae Eun Cheong et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Microglial control of astrocytes in response to microbial metabolites
- (2018) Veit Rothhammer et al. NATURE
- Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
- (2018) Micah T. Nelp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A new cancer immunotherapy suffers a setback
- (2018) Ken Garber SCIENCE
- Modulating Tumor Immunology by Inhibiting Indoleamine 2,3-Dioxygenase (IDO): Recent Developments and First Clinical Experiences
- (2018) Diwakar Davar et al. Targeted Oncology
- Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
- (2018) Jing Gao et al. Frontiers in Cellular and Infection Microbiology
- Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas
- (2018) Maud Toulmonde et al. JAMA Oncology
- Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
- (2018) Asha Nayak-Kapoor et al. Journal for ImmunoTherapy of Cancer
- Abstract 1701: EPL-1410, a novel fused heterocycle based orally active dual inhibitor of IDO1/TDO2, as a potential immune-oncology therapeutic
- (2018) Srinivas Gullapalli et al. CANCER RESEARCH
- The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease
- (2018) Dan Yu et al. JOURNAL OF ALZHEIMERS DISEASE
- Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)
- (2017) Seung-Hyeon Seok et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
- (2017) Ann L. Walker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate
- (2017) Stefano Crosignani et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inflammation-induced depression: Its pathophysiology and therapeutic implications
- (2017) Sang Won Jeon et al. JOURNAL OF NEUROIMMUNOLOGY
- Chromatographic analysis of tryptophan metabolites
- (2017) Ilona Sadok et al. JOURNAL OF SEPARATION SCIENCE
- Frailty Status in Older Adults Is Related to Alterations in Indoleamine 2,3-Dioxygenase 1 and Guanosine Triphosphate Cyclohydrolase I Enzymatic Pathways
- (2017) Diego Marcos-Pérez et al. Journal of the American Medical Directors Association
- Indoleamine-2,3-dioxygenase(IDO)2 polymorphisms are not associated with multiple sclerosis in Italians
- (2017) Cristina Agliardi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production
- (2017) Simone Formisano et al. JOURNAL OF VIROLOGY
- Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography
- (2017) Christoph Reichetzeder et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Monitoring immune-checkpoint blockade: response evaluation and biomarker development
- (2017) Mizuki Nishino et al. Nature Reviews Clinical Oncology
- Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
- (2017) Francesco Fazio et al. NEUROPHARMACOLOGY
- Kynurenine pathway metabolism and the microbiota-gut-brain axis
- (2017) P.J. Kennedy et al. NEUROPHARMACOLOGY
- The kynurenine pathway and the brain: Challenges, controversies and promises
- (2017) Robert Schwarcz et al. NEUROPHARMACOLOGY
- Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
- (2017) Michael D. Lovelace et al. NEUROPHARMACOLOGY
- Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects
- (2017) K.V. Sathyasaikumar et al. NEUROSCIENCE
- NAD Deficiency, Congenital Malformations, and Niacin Supplementation
- (2017) Hongjun Shi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity
- (2017) Magdalena E. Kegel et al. PSYCHIATRY RESEARCH
- Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
- (2017) Igor Cervenka et al. SCIENCE
- NAD + in Aging: Molecular Mechanisms and Translational Implications
- (2017) Evandro F. Fang et al. TRENDS IN MOLECULAR MEDICINE
- Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
- (2017) Jonathan P. Hutchinson et al. Nature Communications
- Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
- (2017) Ariel Lewis-Ballester et al. Nature Communications
- Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
- (2017) Tobias V. Lanz et al. Scientific Reports
- Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
- (2017) Chai K. Lim et al. Scientific Reports
- The IDO–AhR Axis Controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection
- (2017) Eliseu Frank de Araújo et al. Frontiers in Immunology
- The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes
- (2017) Giada Mondanelli et al. Frontiers in Immunology
- Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?
- (2017) Andrew L. Mellor et al. Frontiers in Immunology
- Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer
- (2017) Dyah L. Dewi et al. OncoImmunology
- Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
- (2017) Pilvi Maliniemi et al. OncoImmunology
- Chemical Inhibition of Kynureninase Reduces Pseudomonas aeruginosa Quorum Sensing and Virulence Factor Expression
- (2016) Stephen H. Kasper et al. ACS Chemical Biology
- Dietary Protein, Metabolism, and Aging
- (2016) George A. Soultoukis et al. Annual Review of Biochemistry
- Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice
- (2016) Paul B. Larkin et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- 1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)
- (2016) Ute F. Röhrig et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice
- (2016) Nathaniel S. Woodling et al. BRAIN
- Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
- (2016) René Fuertig et al. BRAIN BEHAVIOR AND IMMUNITY
- Abstract LB-085: RG70099: A novel, highly potent dual IDO1/TDO inhibitor to reverse metabolic suppression of immune cells in the tumor micro-environment
- (2016) Gabor Gyulveszi et al. CANCER RESEARCH
- STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation
- (2016) Henrique Lemos et al. CANCER RESEARCH
- Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies
- (2016) A. M. Monjazeb et al. CLINICAL CANCER RESEARCH
- Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
- (2016) Sandra P. D'Angelo et al. CLINICAL CANCER RESEARCH
- PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors
- (2016) Adrian M. Seifert et al. CLINICAL CANCER RESEARCH
- The end of the road for the tryptophan depletion concept in pregnancy and infection
- (2016) A. A.- B. Badawy et al. CLINICAL SCIENCE
- Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors
- (2016) Jason R. Smith et al. DRUG DISCOVERY TODAY
- Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors
- (2016) Juanjuan Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
- (2016) Vahri Beaumont et al. EXPERIMENTAL NEUROLOGY
- The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities
- (2016) Francesco Antonio Greco et al. Future Medicinal Chemistry
- Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction
- (2016) D Vavrincova-Yaghi et al. GENE THERAPY
- IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
- (2016) Carla Lippens et al. JOURNAL OF AUTOIMMUNITY
- Tolerogenic Phenotype of IFN-γ–Induced IDO+Dendritic Cells Is Maintained via an Autocrine IDO–Kynurenine/AhR–IDO Loop
- (2016) Qingsheng Li et al. JOURNAL OF IMMUNOLOGY
- Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4
- (2016) Katharina Ochs et al. JOURNAL OF NEUROCHEMISTRY
- Ageing, neurodegeneration and brain rejuvenation
- (2016) Tony Wyss-Coray NATURE
- Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
- (2016) Damian J Mole et al. NATURE MEDICINE
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
- (2016) Veit Rothhammer et al. NATURE MEDICINE
- CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
- (2016) Bruno Lamas et al. NATURE MEDICINE
- Xanthurenic acid is localized in neurons in the central nervous system
- (2016) Guy Roussel et al. NEUROSCIENCE
- Kynurenines, Gender and Neuroinflammation; Showcase Schizophrenia
- (2016) J. de Bie et al. NEUROTOXICITY RESEARCH
- Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
- (2016) Carlo Breda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
- (2016) Joel Kaye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
- (2016) H. Zhang et al. SCIENCE
- Tolerogenic dendritic cells
- (2016) Maisa C. Takenaka et al. Seminars in Immunopathology
- IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
- (2016) David H. Munn et al. TRENDS IN IMMUNOLOGY
- An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
- (2016) L Brundin et al. Translational Psychiatry
- Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome
- (2016) Naomi I. Maria et al. Arthritis & Rheumatology
- The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas
- (2016) Jana K. Sonner et al. OncoImmunology
- Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma
- (2016) Anthony R. Guastella et al. Molecular Imaging
- Fibroblast Cell-Based Therapy for Experimental Autoimmune Diabetes
- (2016) Reza B. Jalili et al. PLoS One
- Dynamics of NAD-metabolism: everything but constant
- (2015) C. A. Opitz et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans
- (2015) Clare Edwards et al. BMC GENETICS
- Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
- (2015) Jonathan Savitz et al. BRAIN BEHAVIOR AND IMMUNITY
- A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer
- (2015) Nicholas C. D'Amato et al. CANCER RESEARCH
- Kynurenic Acid Is a Nutritional Cue that Enables Behavioral Plasticity
- (2015) George A. Lemieux et al. CELL
- Role of indoleamine 2,3-dioxygenase in health and disease
- (2015) Amanda W.S. Yeung et al. CLINICAL SCIENCE
- The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy
- (2015) Lijie Zhai et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes
- (2015) Hajime J. Yuasa et al. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
- Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors
- (2015) Ute F. Röhrig et al. JOURNAL OF MEDICINAL CHEMISTRY
- Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
- (2015) Yi-Hui Peng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease
- (2015) Leticia M. Toledo-Sherman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans
- (2015) Edwin B. Yan et al. Journal of Neuroinflammation
- A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
- (2015) C M Sellgren et al. MOLECULAR PSYCHIATRY
- Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: Implications for schizophrenia
- (2015) Michelle L. Pershing et al. NEUROPHARMACOLOGY
- Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development
- (2015) Jennifer E. Cole et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- The kynurenine pathway and neurodegenerative disease
- (2015) Daniel C. Maddison et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Learning from other diseases: protection and pathology in chronic fungal infections
- (2015) Teresa Zelante et al. Seminars in Immunopathology
- Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
- (2015) Paolo Puccetti et al. PLoS One
- Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing- Remitting Multiple Sclerosis
- (2015) Roberta Mancuso et al. PLoS One
- A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
- (2015) Hatem H. Soliman et al. Oncotarget
- The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
- (2014) Brigitta Stockinger et al. Annual Review of Immunology
- Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage
- (2014) Krishna S. Tummala et al. CANCER CELL
- Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
- (2014) George C. Prendergast et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy.
- (2014) Mario R. Mautino et al. CANCER RESEARCH
- The cross talk between microbiota and the immune system: metabolites take center stage
- (2014) Hagit Shapiro et al. CURRENT OPINION IN IMMUNOLOGY
- Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway
- (2014) Martina Ott et al. GLIA
- IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
- (2014) Richard Metz et al. INTERNATIONAL IMMUNOLOGY
- Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes
- (2014) Maria Teresa Pallotta et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation
- (2014) W. Chen et al. JOURNAL OF IMMUNOLOGY
- IDO2 Is a Critical Mediator of Autoantibody Production and Inflammatory Pathogenesis in a Mouse Model of Autoimmune Arthritis
- (2014) L. M. F. Merlo et al. JOURNAL OF IMMUNOLOGY
- Reduction of Brain Kynurenic Acid Improves Cognitive Function
- (2014) R. Kozak et al. JOURNAL OF NEUROSCIENCE
- Aryl hydrocarbon receptor control of a disease tolerance defence pathway
- (2014) Alban Bessede et al. NATURE
- AhR sensing of bacterial pigments regulates antibacterial defence
- (2014) Pedro Moura-Alves et al. NATURE
- Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice
- (2014) Francesco Fazio et al. NEUROPHARMACOLOGY
- Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production
- (2014) Margaret M. Lowe et al. PLoS One
- IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype
- (2014) Alexander Lee et al. PLoS One
- Protein and amino acid restriction, aging and disease: from yeast to humans
- (2014) Hamed Mirzaei et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Indoleamine 2,3-dioxygenase expression and activity in patients with hepatitis C virus-induced liver cirrhosis
- (2014) KASHIF ASGHAR et al. Experimental and Therapeutic Medicine
- Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import
- (2014) Chong He et al. PLoS Genetics
- Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues
- (2014) I. Theate et al. Cancer Immunology Research
- New Insights into IDO Biology in Bacterial and Viral Infections
- (2014) Susanne V. Schmidt et al. Frontiers in Immunology
- The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
- (2014) Minghui Li et al. Journal for ImmunoTherapy of Cancer
- Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity
- (2013) Petr Tomek et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress
- (2013) F. Sahm et al. CANCER RESEARCH
- Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing
- (2013) Yanjia J. Zhang et al. CELL
- Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
- (2013) Teresa Zelante et al. IMMUNITY
- Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
- (2013) Rikke B. Holmgaard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration
- (2013) Xiao-Qian Liu et al. LEUKEMIA & LYMPHOMA
- The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1 and with increased CSF KYNA level and reduced KMO expression
- (2013) C Lavebratt et al. MOLECULAR PSYCHIATRY
- Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid
- (2013) Zuzana Justinova et al. NATURE NEUROSCIENCE
- Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain
- (2013) Wei Wu et al. PLoS One
- Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection
- (2013) Lei Huang et al. PLoS One
- The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia
- (2013) Hannah F. Iaccarino et al. SCHIZOPHRENIA RESEARCH
- Tryptophan metabolism: entering the field of aging and age-related pathologies
- (2013) Annemieke T. van der Goot et al. TRENDS IN MOLECULAR MEDICINE
- High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway
- (2013) Claudia Volpi et al. Nature Communications
- Serum Metabolome and Lipidome Changes in Adult Patients with Primary Dengue Infection
- (2013) Liang Cui et al. PLoS Neglected Tropical Diseases
- Indoleamine 2,3-dioxygenase activity and clinical outcome following induction chemotherapy and concurrent chemoradiation in Stage III non-small cell lung cancer
- (2013) Ben C. Creelan et al. OncoImmunology
- Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
- (2012) M. Platten et al. CANCER RESEARCH
- Immunological and Nonimmunological Effects of Indoleamine 2,3-Dioxygenase on Breast Tumor Growth and Spontaneous Metastasis Formation
- (2012) Vera Levina et al. Clinical & Developmental Immunology
- Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
- (2012) Tracy L. McGaha et al. IMMUNOLOGICAL REVIEWS
- Induction of Indoleamine 2,3-Dioxygenase by Uropathogenic Bacteria Attenuates Innate Responses to Epithelial Infection
- (2012) Jennifer A. Loughman et al. JOURNAL OF INFECTIOUS DISEASES
- Kynurenines in the mammalian brain: when physiology meets pathology
- (2012) Robert Schwarcz et al. NATURE REVIEWS NEUROSCIENCE
- Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
- (2012) B. Ravishankar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis
- (2012) A. Yeste et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
- (2012) L. Pilotte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
- (2012) A. T. van der Goot et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An expanding range of targets for kynurenine metabolites of tryptophan
- (2012) Trevor W. Stone et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia
- (2012) Amy B. Dounay et al. ACS Medicinal Chemistry Letters
- IDO Is a Nodal Pathogenic Driver of Lung Cancer and Metastasis Development
- (2012) Courtney Smith et al. Cancer Discovery
- Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
- (2011) Daniel Zwilling et al. CELL
- The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease
- (2011) Susanna Campesan et al. CURRENT BIOLOGY
- Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism
- (2011) Gregory F. Oxenkrug et al. FLY
- Inhibition of Indoleamine 2,3-Dioxygenase Activity by Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia trachomatis Persistence in Human Epithelial Cells
- (2011) Joyce A. Ibana et al. INFECTION AND IMMUNITY
- Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
- (2011) Maria Holtze JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive
- (2011) Jessica Godin-Ethier et al. MOLECULAR IMMUNOLOGY
- Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
- (2011) A K Smith et al. MOLECULAR PSYCHIATRY
- An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
- (2011) Christiane A. Opitz et al. NATURE
- Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
- (2011) Vinod P Balachandran et al. NATURE MEDICINE
- The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells
- (2011) Christiane A. Opitz et al. PLoS One
- Tryptophan metabolism, from nutrition to potential therapeutic applications
- (2010) Nathalie Le Floc’h et al. AMINO ACIDS
- Dioxin and immune regulation
- (2010) Nikki B. Marshall et al. Annals of the New York Academy of Sciences
- An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
- (2010) J. D. Mezrich et al. JOURNAL OF IMMUNOLOGY
- IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis
- (2010) Y. Yan et al. JOURNAL OF IMMUNOLOGY
- Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement
- (2010) Franca Rossi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Kynurenine is an endothelium-derived relaxing factor produced during inflammation
- (2010) Yutang Wang et al. NATURE MEDICINE
- Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
- (2010) N. T. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
- (2010) F. J. Quintana et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia
- (2010) K. V. Sathyasaikumar et al. SCHIZOPHRENIA BULLETIN
- Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease
- (2010) D. Favre et al. Science Translational Medicine
- Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling
- (2010) Brett C. DiNatale et al. TOXICOLOGICAL SCIENCES
- Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis
- (2010) Yanying Liu et al. ARTHRITIS RESEARCH & THERAPY
- Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis
- (2009) Gabriel Criado et al. ARTHRITIS AND RHEUMATISM
- Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
- (2009) D. J. Chung et al. BLOOD
- Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer
- (2009) Feng Qian et al. CANCER RESEARCH
- Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase
- (2009) Silvia K. Schmidt et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma
- (2009) Tomoko Inaba et al. GYNECOLOGIC ONCOLOGY
- Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells
- (2009) M. Brenk et al. JOURNAL OF IMMUNOLOGY
- The Immunoregulatory Enzyme IDO Paradoxically Drives B Cell-Mediated Autoimmunity
- (2009) G. N. Scott et al. JOURNAL OF IMMUNOLOGY
- IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes
- (2009) F. Fallarino et al. JOURNAL OF IMMUNOLOGY
- The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine
- (2009) Gregory F. Oxenkrug JOURNAL OF NEURAL TRANSMISSION
- Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
- (2009) Yuzo Suzuki et al. LUNG CANCER
- Toll-Like Receptor Engagement Enhances the Immunosuppressive Properties of Human Bone Marrow-Derived Mesenchymal Stem Cells by Inducing Indoleamine-2,3-dioxygenase-1 via Interferon-β and Protein Kinase R
- (2009) Christiane A. Opitz et al. STEM CELLS
- Mouse Mesenchymal Stem Cells Suppress Antigen-Specific TH Cell Immunity Independent of Indoleamine 2,3-Dioxygenase 1 (IDO1)
- (2009) Tobias V. Lanz et al. STEM CELLS AND DEVELOPMENT
- Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
- (2009) Masaaki Kanai et al. Molecular Brain
- Sequence Variants in Kynurenine Aminotransferase II (KAT II) Orthologs Determine Different Potencies of the InhibitorS-ESBA
- (2008) Roberto Pellicciari et al. ChemMedChem
- Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival
- (2008) K. Ino et al. CLINICAL CANCER RESEARCH
- Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma
- (2008) Ke Pan et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection
- (2008) Agnes Witkiewicz et al. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
- Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
- (2008) T ZELANTE et al. MICROBES AND INFECTION
- SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
- (2008) C. Orabona et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation