Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
出版年份 2017 全文链接
标题
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase
作者
关键词
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出版物
Nature Communications
Volume 8, Issue -, Pages 15827
出版商
Springer Nature
发表日期
2017-06-12
DOI
10.1038/ncomms15827
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
- (2017) Ann L. Walker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors
- (2016) Jason R. Smith et al. DRUG DISCOVERY TODAY
- The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
- (2016) Vahri Beaumont et al. EXPERIMENTAL NEUROLOGY
- Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
- (2016) Damian J Mole et al. NATURE MEDICINE
- Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
- (2016) Michael D. Lovelace et al. Frontiers in Immunology
- Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
- (2016) Christos Skouras et al. Scientific Reports
- The drug–target residence time model: a 10-year retrospective
- (2015) Robert A. Copeland NATURE REVIEWS DRUG DISCOVERY
- Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase
- (2014) Jeremy W. Setser et al. BIOCHEMISTRY
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Activation of NAD(P)H Oxidase by Tryptophan-Derived 3-Hydroxykynurenine Accelerates Endothelial Apoptosis and Dysfunction In Vivo
- (2013) Qiongxin Wang et al. CIRCULATION RESEARCH
- Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation
- (2013) Stefania Montersino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural basis of kynurenine 3-monooxygenase inhibition
- (2013) Marta Amaral et al. NATURE
- Structural Insight into the Mechanism of Oxygen Activation and Substrate Selectivity of Flavin-Dependent N-Hydroxylating Monooxygenases
- (2012) Stefano Franceschini et al. BIOCHEMISTRY
- Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases
- (2012) Karen Crozier-Reabe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Kynurenines in the CNS: recent advances and new questions
- (2012) László Vécsei et al. NATURE REVIEWS DRUG DISCOVERY
- Data processing and analysis with theautoPROCtoolbox
- (2011) Clemens Vonrhein et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM
- (2011) T. Geoff G. Battye et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
- (2011) Daniel Zwilling et al. CELL
- Two Structures of anN-Hydroxylating Flavoprotein Monooxygenase
- (2011) Jose Olucha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Are pyridazines privileged structures?
- (2011) Camille G. Wermuth MedChemComm
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Incidence of individual organ dysfunction in fatal acute pancreatitis: analysis of 1024 death records
- (2010) Damian J. Mole et al. HPB
- Control of catalysis in flavin-dependent monooxygenases
- (2009) Bruce A. Palfey et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan
- (2009) Xiaofeng Zhu et al. JOURNAL OF MOLECULAR BIOLOGY
- FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data
- (2008) Kenneth A. Johnson et al. ANALYTICAL BIOCHEMISTRY
- Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data
- (2008) Kenneth A. Johnson et al. ANALYTICAL BIOCHEMISTRY
- Kynurenine 3-Monooxygenase fromPseudomonas fluorescens: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin−Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide
- (2008) Karen R. Crozier-Reabe et al. BIOCHEMISTRY
- Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function
- (2008) Peter J. Tummino et al. BIOCHEMISTRY
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