Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Cerebral cortex, hippocampus, striatum and cerebellum show differential susceptibility to quinolinic acid-induced oxidative stress

(2015) Samuel Vandresen-Filho et al.   NEUROLOGICAL SCIENCES

Inhibitors of quinolinic acid synthesis: new weapons in the study of neuroinflammatory diseases

(2014) Gabriele Costantino   Future Medicinal Chemistry

Post-Traumatic Hypoxia Is Associated with Prolonged Cerebral Cytokine Production, Higher Serum Biomarker Levels, and Poor Outcome in Patients with Severe Traumatic Brain Injury

(2013) Edwin B. Yan et al.   JOURNAL OF NEUROTRAUMA

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Indoleamine 2,3-dioxygenase: From catalyst to signaling function

(2012) Francesca Fallarino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Quinolinic acid: neurotoxicity

(2012) Gilles J. Guillemin   FEBS Journal

Quinolinic acid, the inescapable neurotoxin

(2012) Gilles J. Guillemin   FEBS Journal

Expression and Activation of EphA4 in the Human Brain After Traumatic Injury

(2012) Tony Frugier et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Modulation of LPA Receptor Expression in the Human Brain Following Neurotrauma

(2011) Tony Frugier et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

(2010) Jenna M. Ziebell et al.   Neurotherapeutics

LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia

(2009) Yunxia Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

(2009) Qian Han et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multisite protein phosphorylation - from molecular mechanisms to kinetic models

(2009) Carlos Salazar et al.   FEBS Journal

Proinflammatory cytokine interferon-γ increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid β peptide 1-42: implications for the pathogenesis of Alzheimer’s disease

(2009) Akiko Yamada et al.   JOURNAL OF NEUROCHEMISTRY

Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington’s disease

(2009) Caroline M. Forrest et al.   JOURNAL OF NEUROCHEMISTRY

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

(2009) Tony Frugier et al.   JOURNAL OF NEUROTRAUMA

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis

(2009) Yiquan Chen et al.   NEUROTOXICITY RESEARCH

Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats

(2009) Harikesh Kalonia et al.   INFLAMMOPHARMACOLOGY

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

(2008) Qian Han et al.   BIOSCIENCE REPORTS

KYNURENINE METABOLITES AND INFLAMMATION MARKERS IN DEPRESSED PATIENTS TREATED WITH FLUOXETINE OR COUNSELLING

(2008) Gillian M Mackay et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Tryptophan degradation in multiple trauma patients: survivors compared with non-survivors

(2008) Martin Ploder et al.   CLINICAL SCIENCE