Article
Psychiatry
Junchao Huang, Jinghui Tong, Ping Zhang, Yanfang Zhou, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Peter Kochunov, Joshua Chiappelli, Baopeng Tian, Li Tian, Yunlong Tan, L. Elliot Hong
Summary: This study found that patients with schizophrenia had significantly lower serum levels of KYNA and QUIN, and higher 5-HI/KYNA and QUIN/KYNA ratios compared to healthy controls. Patients with high 5-HI and low KYNA showed better working memory, and higher 5-HI levels were associated with thicker cortex in a specific brain area among patients. The different effects of 5-HI and KYNA on cognitive function suggest potential for novel therapeutic development targeting cognitive impairment in schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Immunology
Diego Scheggia, Jennifer Stanic, Maria Italia, Filippo La Greca, Elisa Zianni, Alberto Benussi, Barbara Borroni, Monica Di Luca, Fabrizio Gardoni
Summary: Autoantibodies targeting the GluA3 subunit of AMPARs have been found in patients with Rasmussen's encephalitis and epilepsy, and associated with learning and attention deficits. The presence of anti-GluA3 IgG in FTD patients suggests a novel pathogenic role in chronic neurodegenerative diseases. In vivo preclinical data provide insights into autoimmune encephalitis associated with anti-GluA3 IgG and indicate an additional pathological mechanism affecting excitatory synapses in FTD patients.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevensek, Dick F. Swaab
Summary: This study identified expression changes in PACAP-related genes that are associated with schizophrenia, suicide, and gender. Upregulation of PACAP, PAC1, VPAC1, and VPAC2 was observed in the ACC of suicide completers with schizophrenia. Additionally, an increase in PAC1 expression was found in the DLPFC of schizophrenia patients who died naturally compared to suicide completers and controls.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Xiao-Yuan Jing, Yan Wang, Hua-Wei Zou, Zi-Lin Li, Ying-Juan Liu, Lai-Fu Li
Summary: The study assessed the functional roles of mGlu2/3 and mGlu5 within different subregions of the mPFC in modulating stress resilience and vulnerability, with results suggesting that mGlu2/3 in the PrL might play an important regulatory role in stress-related psychiatric disorders. Social avoidance symptoms in susceptible mice were rapidly relieved by intra-PrL administration of an mGluR2/3 antagonist, indicating a potential avenue for developing novel, personalized approaches to mitigate depression and promote stress resilience.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazzi
Summary: Traumatic stress is a significant risk factor for psychiatric disorders. This study investigates the effects of acute footshock stress and ketamine on the glutamatergic synaptic plasticity in the prefrontal cortex. The findings suggest that acute stress and ketamine induce changes in dopamine-dependent long-term potentiation (LTP) as well as ionotropic glutamate receptor subunit expression and localization. Further research is needed, but this initial report supports the potential benefit of acute ketamine in mitigating the impact of acute traumatic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
J. Titulaer, O. Radhe, K. Danielsson, S. Dutheil, M. M. Marcus, K. Jardemark, T. H. Svensson, G. L. Snyder, M. Ericson, R. E. Davis, A. Konradsson-Geuken
Summary: Lumateperone is a novel drug approved for the treatment of schizophrenia and depressive episodes associated with bipolar depression. It simultaneously modulates key neurotransmitters and improves symptoms while enhancing prosocial behavior. The drug affects dopamine and glutamate signaling, potentially contributing to its effectiveness in improving mood-related symptoms.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Giorgia Targa, Francesca Mottarlini, Beatrice Rizzi, Damiana Leo, Lucia Caffino, Fabio Fumagalli
Summary: Dopamine overactivity reduces the translation and localization of cortical AMPA receptors through altered vesicular sorting. The decreased expression of anchoring proteins and structural markers indicates synaptic instability. Hyperdopaminergia significantly alters the homeostatic plasticity of AMPA receptors, leading to a destabilized and depotentiated AMPA-mediated glutamatergic neurotransmission in the prefrontal cortex.
Article
Psychiatry
Tiziana Imbriglio, Marika Alborghetti, Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti, Milena Cannella
Summary: The study found that TAAR1 mRNA levels were increased in the SCZ prefrontal cortex, with no correlation to various factors. Differences in TAAR1 protein levels were observed between neuropathological burden subgroups of CTRL, but not within the SCZ group. TAAR1 protein levels were lower in CTRL with low neuropathological burden compared to all SCZ samples or SCZ samples with low neuropathological burden. In the SCZ group, TAAR1 protein levels were inversely correlated with duration of antipsychotic treatment and higher in individuals treated with second-generation antipsychotics.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Neurosciences
Trevor W. Stone
Summary: Ionotropic glutamate receptors and nicotinic receptors for acetylcholine have interactions, including mutual regulation of subunit expression, existence of multi-functional receptor complexes, and impacts on transmitter release, cellular electrophysiology and behavior. Understanding these interactions can lead to new insights into the sites of action of glutamate and nicotinic receptor ligands for drug development.
Article
Biochemistry & Molecular Biology
Hidekazu Sotoyama, Hiroyoshi Inaba, Yuriko Iwakura, Hisaaki Namba, Nobuyuki Takei, Toshikuni Sasaoka, Hiroyuki Nawa
Summary: Dopamine in the prefrontal cortex has opposing effects on social behavior depending on the duration of its activation. Sustained dopamine activation suppresses social behavior while acute activation enhances it. The duration of social interactions is positively correlated with transient dopamine release and negatively correlated with sustained dopamine increase in the prefrontal cortex. Dopamine levels also modulate neural calcium signaling and c-Fos induction triggered by social stimuli in prefrontal neurons.
Article
Biochemistry & Molecular Biology
Alma Hrnjadovic, James Friedmann, Sandra Barhebreus, Patricia J. Allen, Bernat Kocsis
Summary: The study aimed to investigate the role of 5-HT7 receptors in the reversal learning component of ASST and found that 5-HT7 receptor antagonist could reverse the impaired performance induced by NMDA receptor blockade, particularly affecting the reversal phases of ASST.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Nobutaka Shimizu, Takahiro Shimizu, Youichirou Higashi, Suo Zou, Hideo Fukuhara, Takashi Karashima, Keiji Inoue, Motoaki Saito
Summary: In our previous study, we found that & alpha;7 nicotinic acetylcholine receptors in the brain inhibited the rat micturition reflex, and we investigated the relationship between & alpha;7 nicotinic acetylcholine receptors and hydrogen sulphide (H2S) as H2S also inhibits the rat micturition reflex in the brain. Through cystometry in male Wistar rats, we examined the effects of H2S and H2S synthesis inhibitor on the activation of & alpha;7 nicotinic acetylcholine receptors in prolonging intercontraction intervals. Our results suggest that brain H2S may be involved in inhibiting the rat micturition reflex induced by activation of brain & alpha;7 nicotinic acetylcholine receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gomez-Santacana, Amadeu Llebaria, Francesco Ferraguti
Summary: This study aimed to assess the impact of mGlu(5) inactivation on neuronal oscillatory activity during fear retrieval in cued fear conditioned mice, showing that inhibition of mGlu(5) signaling decreased freezing behavior during fear retrieval and reduced theta rhythmic activity in both the mPFC and vHPC.
Article
Endocrinology & Metabolism
Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Summary: This article investigates the sex differences in glutamatergic transmission within the medial prefrontal cortex, finding higher levels of glutamatergic transmission in females. This provides important evidence for the development of sex-specific pharmacotherapies for psychiatric diseases.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Biochemistry & Molecular Biology
Melanie Druart, Marika Nosten-Bertrand, Stefanie Poll, Sophie Crux, Felix Nebeling, Celia Delhaye, Yaelle Dubois, Manuel Mittag, Marion Leboyer, Ryad Tamouza, Martin Fuhrmann, Corentin Le Magueresse
Summary: Accumulated evidence suggests that high expression variants of the C4 gene are associated with susceptibility to schizophrenia. Overexpression of C4 in the mouse prefrontal cortex leads to reduced spine density and glutamatergic input to pyramidal cells. These deficits may be attributed to decreased dendritic spine formation and hypofunction of NMDA receptors in juvenile C4-OE mice.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Britta Hahn, Carolyn H. Reneski, Ana Pocivavsek, Robert Schwarcz
PSYCHOPHARMACOLOGY
(2018)
Article
Psychiatry
Ana Pocivavsek, Laura M. Rowland
SCHIZOPHRENIA BULLETIN
(2018)
Article
Neurosciences
Ana Pocivavsek, Greg I. Elmer, Robert Schwarcz
Article
Pharmacology & Pharmacy
Christinna V. Jorgensen, Hong Zhou, Markus J. Seibel, Hans Brauner-Osborne
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Article
Multidisciplinary Sciences
Christinna V. Jorgensen, Sylvia J. Gasparini, Jinwen Tu, Hong Zhou, Markus J. Seibel, Hans Brauner-Osborne
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Annalisa M. Baratta, Nickole R. Kanyuch, Casey A. Cole, Homayoun Valafar, Jessica Deslauriers, Ana Pocivavsek
NEUROBIOLOGY OF STRESS
(2020)
Article
Behavioral Sciences
Silas A. Buck, Annalisa M. Baratta, Ana Pocivavsek
NEUROBIOLOGY OF LEARNING AND MEMORY
(2020)
Article
Psychiatry
Katherine M. Rentschler, Annalisa M. Baratta, Audrey L. Ditty, Nathan T. J. Wagner, Courtney J. Wright, Snezana Milosavljevic, Jessica A. Mong, Ana Pocivavsek
Summary: The study found that prenatal kynurenine exposure induces sex-specific changes in sleep-wake behavior, arousal, and KP metabolism in offspring.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Clinical Neurology
Philip C. Smith, Derrick J. Phillips, Ana Pocivavsek, Carissa A. Byrd, Shaun S. Viechweg, Brian Hampton, Jessica A. Mong
Summary: The study investigated the effects of estradiol (E2) on sleep, finding that E2 decreases homeostatic sleep need and influences adenosine signaling in the MnPO. These results suggest that E2 may attenuate the local effects of A(2A) receptors in the MnPO, potentially explaining estrogenic suppression of sleep behavior and changes in homeostatic sleep need.
Article
Psychiatry
Courtney J. Wright, Katherine M. Rentschler, Nathan T. J. Wagner, Ashley M. Lewis, Sarah Beggiato, Ana Pocivavsek
Summary: Hypofunction of glutamatergic signaling is linked to neurodevelopmental disorders such as schizophrenia and bipolar disorder, with KYNA playing a potential role in the cognitive dysfunction experienced by patients. The EKyn paradigm induced prenatal KYNA elevation in rats to investigate its effects, showing potential sex- and time-dependent changes in hippocampal neuromodulation. This research sheds light on how prenatal insults may influence behavioral phenotypes related to psychotic disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Snezana Milosavljevic, Andrew K. Smith, Courtney J. Wright, Homayoun Valafar, Ana Pocivavsek
Summary: Dysregulated sleep is commonly reported in individuals with neuropsychiatric disorders, including schizophrenia and bipolar disorder. The physiology and pathogenesis of these disorders suggest abnormal metabolism of tryptophan via the kynurenine pathway, leading to increased levels of the neuroactive metabolite kynurenic acid (KYNA). This study investigated the hypothesis that elevated KYNA contributes to sleep dysfunction and examined the effects of pharmacological inhibition of the enzyme KAT II on sleep quality.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Courtney J. Wright, Snezana Milosavljevic, Ana Pocivavsek
Summary: Sleep is essential for daily functioning and homeostatic balance, and sleep deprivation can have detrimental physiological consequences. However, the role of biological sex in the response to sleep loss is often overlooked, particularly in women and female rodents. Understanding sex differences in the stress response and other effects of sleep deprivation can greatly improve our ability to address the health consequences of insufficient sleep. This review explores the various ways in which sleep loss affects men and women differently, including the activation of stress pathways and other physiological changes.
NEUROBIOLOGY OF STRESS
(2023)
Editorial Material
Neurosciences
Ana Pocivavsek, Sophie Erhardt
NEUROPSYCHOPHARMACOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Andrew Smith, Hardik Anand, Snezana Milosavljevic, Katherine M. Rentschler, Ana Pocivavsek, Homayoun Valafar
Summary: The study demonstrates the potential of various machine learning classifiers to automatically, accurately, and reliably classify vigilance states based on a single EEG reading and a single EMG reading, with Random Forest and Artificial Neural Network performing notably well.
2021 INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE AND COMPUTATIONAL INTELLIGENCE (CSCI 2021)
(2021)
Letter
Pharmacology & Pharmacy
C. Renay Friendshuh, Ana Pocivavsek, Haley Demyonovich, Katrina M. Rodriguez, Daniela Cihakova, Monica V. Talor, Charles M. Richardson, Gopal Vyas, Heather A. Adams, Annalisa B. Baratta, Alessio Fasano, Nicola Cascella, Stephanie Feldman, Fang Liu, Mackenzie Sayer, Megan M. Powell, Heidi J. Wehring, Robert W. Buchanan, William T. Carpenter, William W. Eaton, Deanna L. Kelly
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2020)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.