期刊
FUTURE MEDICINAL CHEMISTRY
卷 8, 期 1, 页码 39-54出版社
FUTURE SCI LTD
DOI: 10.4155/fmc.15.165
关键词
antibacterial; antifungal; antiviral; cancer; drug design; IDO; inhibitor; tryptophan
资金
- Italian Ministry of University and Research [PRIN 2012S47X27]
Inhibition of IDO1 is a strategy pursued to develop novel therapeutic treatments for cancer. Recent years have witnessed growing evidence that the enzyme plays a pivotal role in viral, bacterial and fungal infections. These studies have underscored the Janus-faced nature of IDO1 in the regulation of host-pathogen interactions and commensalism. Starting with an outlook on the advances in the structural features of IDO1, herein we report recent findings that pinpoint the involvement of IDO1 in infectious diseases. Then, we present an overview of IDO1 inhibitors that have been enrolled in clinical trials as well as other distinct modulators of the enzyme
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