Article
Sport Sciences
Anasua Pal, Philipp Zimmer, Dorothea Clauss, Martina E. Schmidt, Cornelia M. Ulrich, Joachim Wiskemann, Karen Steindorf
Summary: In pancreatic cancer patients undergoing surgery and chemotherapy, supervised resistance exercise was found to decrease kynurenine and kynurenine/tryptophan ratio levels, increase tryptophan levels, and modulate the immune system.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2021)
Article
Fisheries
Yimu Luan, Yaocen Wang, Wentong Zhang, Xuyuan Duan, Peng Su, Qingwei Li, Yue Pang, Meng Gou
Summary: This study cloned and identified six TRP-KYN pathway-related genes from the lamprey. These genes were found to play a role in immunosuppression, inflammatory response, and tumor suppression. The key gene Lj-TDO was highly expressed in the oral gland. Real-time quantitative PCR showed significant upregulation of TRP-KYN pathway-related genes after multi-stimulation. RNA interference of Lj-IDO2 regulated the expression of inflammatory factors. This study provides valuable insights into the ancestral features and functions of the TRP-KYN pathway, as well as its involvement in the immune responses of jawless vertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Cell Biology
Filip Jovanovic, Visnja Jovanovic, Nebojsa Nick Knezevic
Summary: The development of chronic pain involves complex interactions among the nervous, immune, and endocrine systems. Chronic pain, lasting for more than 3 months, is increasingly common in the US adult population. Pro-inflammatory cytokines contribute to chronic pain and affect the tryptophan metabolism and the hypothalamic-pituitary-adrenal axis. Glucocorticoids and metabolites of the kynurenine pathway may serve as biomarkers and potential therapeutic targets for chronic pain.
Article
Oncology
Peng Li, Ruan Wu, Ke Li, Wenhui Yuan, Chuqian Zeng, Yuting Zhang, Xiao Wang, Xinhai Zhu, Jianjun Zhou, Ping Li, Yunfei Gao
Summary: The study found that IDO1 and PD-L1 were highly expressed in TNBC patients, and Vγ9Vδ2 T cells became exhausted in these patients. Combining Vγ9Vδ2 T cells with IDO1 inhibitor may be applicable for TNBC treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Michael Platten, Mirco Friedrich, Derek A. Wainwright, Verena Panitz, Christiane A. Opitz
Summary: Tryptophan metabolism plays a crucial role in cancer immunotherapy, particularly in promoting malignant phenotypes and immunosuppressive tumor microenvironments in brain tumors. Recent research has advanced our understanding of the role of tryptophan metabolism and its metabolites in regulating brain function and neuronal integrity, as well as potential therapeutic targets for glioma treatment.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Review
Chemistry, Medicinal
Andrea Mammoli, Alessandra Riccio, Elisa Bianconi, Alice Coletti, Emidio Camaioni, Antonio Macchiarulo
Summary: This article provides a comparative overview on the recent advancements in crystallographic studies, biophysical and computational works regarding the structural aspects and molecular recognition patterns of enzymes involved in the catabolic pathways of l-Tryptophan. Additionally, the enzymes are explored as potential drug targets for various disorders, such as carcinoid syndrome, cancer, and autoimmune diseases. Further discussions include a conformational analysis of l-Tryptophan in the molecular recognition process.
Review
Oncology
Chenwei Li, Hui Zhao
Summary: Lung cancer is the most lethal malignancy worldwide, and tryptophan and its metabolites play important roles in regulating the progression of lung cancer, including modulating the tumor environment, promoting immune suppression, and drug resistance. Progress has been made in therapeutic drugs targeting tryptophan metabolism and the kynurenine pathway, with ongoing clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lihui Guo, Bernadette Schurink, Eva Roos, Esther J. Nossent, Jan Willem Duitman, Alexander P. J. Vlaar, Paul van der Valk, Frederic M. Vaz, Syun-Ru Yeh, Zachary Geeraerts, Annemiek Dijkhuis, Lonneke van Vught, Marianna Bugiani, Rene Lutter
Summary: COVID-19 is associated with the accumulation of tryptophan degradation products in the lungs, heart, and brain. The expression of IDO-2, an isoform rarely expressed, is related to cell death and severe cellular stress in these organs. The early activation of the kynurenine/aryl-hydrocarbon receptor/IDO-2 axis may contribute to the pathology of severe COVID-19.
JOURNAL OF PATHOLOGY
(2022)
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Review
Oncology
Trevor W. Stone, Richard O. Williams
Summary: This review focuses on the role of tryptophan metabolism in inflammation and cancer development, particularly the impact of kynurenine and related compounds. It proposes targeting the kynurenine pathway to indirectly affect interacting pathways and potentially modify tryptophan metabolism. The study provides insights into the relationship between inflammation and cancer, and suggests alternative drug targets.
Article
Immunology
Eliseu F. de Araujo, Flavio V. Loures, Nycolas W. Preite, Claudia Feriotti, Nayane A. L. Galdino, Tania A. Costa, Vera L. G. Calich
Summary: This study demonstrated the modulation of pathogen loads and immune response in pulmonary paracoccidioidomycosis by AhR ligands, with different AhR agonists and antagonists affecting host response differently. Further research is needed to determine the potential use of these compounds as adjuvant therapy for this fungal infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Minah Kim, Petr Tomek
Summary: Blocking tryptophan catabolism mediated by IDO1 and TDO shows promise for sensitising cancer patients to immune checkpoint blockade. Understanding the immune-regulatory function of tryptophan catabolism could lead to optimized therapeutic strategies. Tryptophan may act as a rheostat of kynurenine-mediated immunosuppression by competing for entry into immune T-cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Frederike T. Fellendorf, Johanna M. Gostner, Melanie Lenger, Martina Platzer, Armin Birner, Alexander Maget, Robert Queissner, Adelina Tmava-Berisha, Cornelia A. Pater, Michaela Ratzenhofer, Jolana Wagner-Skacel, Susanne A. Bengesser, Nina Dalkner, Dietmar Fuchs, Eva Z. Reininghaus
Summary: The study found abnormalities in tryptophan metabolism in patients with BD, with accelerated breakdown of tryptophan associated with overweight, but not necessarily linked to clinical manifestations. The results suggest that tryptophan, kynurenine, and IDO-1 activity may play a role in the pathophysiology of BD.
Article
Gastroenterology & Hepatology
Xin Zhang, Xiuting Liu, Wei Zhou, Qianming Du, Mengdi Yang, Yang Ding, Rong Hu
Summary: This study identified the role of kynurenine (Kyn) and indoleamine 2,3-dioxygenase (IDO) in regulating tumor-infiltrating T cells and adaptive immunity in colorectal cancer (CRC). Inhibition of IDO diminished Kyn/AhR-mediated regulatory T cell (Treg) differentiation, providing a potential strategy for the prevention and treatment of inflammation-related colon cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Philipp Vollmuth, Martha Foltyn, Raymond Y. Huang, Norbert Galldiks, Jens Petersen, Fabian Isensee, Martin J. van den Bent, Frederik Barkhof, Ji Eun Park, Yae Won Park, Sung Soo Ahn, Gianluca Brugnara, Hagen Meredig, Rajan Jain, Marion Smits, Whitney B. Pope, Klaus Maier-Hein, Michael Weller, Patrick Y. Wen, Wolfgang Wick, Martin Bendszus
Summary: This study aimed to assess the reproducibility and standardization of treatment response assessment using artificial intelligence (AI) decision support in MRI. The results showed that AI decision support can provide better evaluation of treatment response in patients with lower-grade gliomas compared to manual measurements.
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Martin van den Bent, Wolfgang Wick, Alba A. Brandes, Martin J. B. Taphoorn, Michael Platten, Ahmed Idbaih, Paul M. Clement, Matthias Preusser, Vassilis Golfinopoulos, Thierry Gorlia, Michael Weller
Summary: This study retrospectively analyzed the incidence of lomustine-induced thrombocytopenia and its impact on treatment exposure and survival in patients with recurrent glioblastoma. The results showed that thrombocytopenia induced by lomustine is a major limitation to adequate exposure to lomustine chemotherapy and is associated with inferior progression-free survival, particularly in patients with MGMT promoter-methylated tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Sofia Doubrovinskaia, Christoph M. Mooshage, Corinna Seliger, Hanns-Martin Lorenz, Simon Nagel, Pascal Lehnert, Jan Purrucker, Brigitte Wildemann, Martin Bendszus, Wolfgang Wick, Silvia Schoenenberger, Leon D. Kaulen
Summary: This study reports the long-term clinical, laboratory, and imaging characteristics of patients with neurological autoimmunity diagnosed in temporal association (<= 6 weeks) with SARS-CoV-2 vaccinations. The condition of most patients improved following therapy, and re-vaccinations were well tolerated. The results suggest that re-vaccinations should be considered based on individual risk-benefit analysis.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nicolas Wenzel, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele
Summary: This study investigated tissue integrity in the spinal cord and brain of multiple sclerosis (MS) patients using the T1/T2-weighted ratio. It found that patients with iron rim lesions (IRLs) had higher disability scores and smaller cross-sectional area of the upper cervical cord, while their T1/T2w values were significantly lower compared to non-IRLs. Furthermore, T1/T2w values of lesions were lower compared to normal-appearing white and gray matter in both the brain and spinal cord. The study suggests that IRLs can serve as an imaging marker of disease severity and the T1/T2w ratio maps can provide insights into the pathophysiological processes of MS.
JOURNAL OF NEUROIMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Wittayer, Claudia E. Weber, Julia Kraemer, Michael Platten, Lucas Schirmer, Achim Gass, Philipp Eisele
Summary: This study investigated the differences in lesion and structural connectivity tissue damage between iron rim lesions (IRLs) and non-IRLs in multiple sclerosis (MS). The results showed that IRLs had lower tissue integrity, but this did not lead to higher disruption to structural connectivity networks.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Qiuqin Zhou, Stefano Rizzo, Janina Oetjen, Annabelle Fueloep, Miriam Rittner, Hartmut Gillandt, Carsten Hopf
Summary: Insufficient vacuum stability of matrix chemicals is a major limitation in MALDI mass spectrometry imaging of large tissue sample cohorts. A photo-cleavable caged molecule, DMNB-2,5-DHAP, was designed and synthesized for lipid MALDI-MSI of mouse brain tissue sections. DMNB-2,5-DHAP exhibited vacuum stability in a high vacuum MALDI ion source and its uncaging process resulted in the generation of 2,5-DHAP with the assistance of the built-in laser in the MALDI ion source.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Denis Abu Sammour, James L. Cairns, Tobias Boskamp, Christian Marsching, Tobias Kessler, Carina Ramallo Guevara, Verena Panitz, Ahmed Sadik, Jonas Cordes, Stefan Schmidt, Shad A. Mohammed, Miriam F. Rittel, Mirco Friedrich, Michael Platten, Ivo Wolf, Andreas von Deimling, Christiane A. Opitz, Wolfgang Wick, Carsten Hopf
Summary: Mass spectrometry imaging utilizes traditional ion images for metabolite visualization and analysis, but lacks consideration for nonlinearities and statistical significance. The computational framework moleculaR aims to improve signal reliability by Gaussian-weighting ion intensities and introduces probabilistic molecular mapping for statistically significant spatial abundance analysis. It allows cross-tissue comparisons and spatial statistical significance evaluation, facilitating the investigation of ion milieus, lipid remodeling pathways, and complex scores within the same image.
NATURE COMMUNICATIONS
(2023)
Letter
Clinical Neurology
Ramin Rahmanzade, Elke Pfaff, Rouzbeh Banan, Philipp Sievers, Abigail K. Suwala, Felix Hinz, Henri Bogumil, Asan Cherkezov, Aras Fuat Kaan, Daniel Schrimpf, Dennis Friedel, Kirsten Goebel, Felix Keller, Xavier Saenz-Sarda, Alexander Lossos, Martin Sill, Olaf Witt, Oliver W. Sakowitz, Andrey Korshunov, David E. Reuss, Nima Etminan, Andreas Unterberg, Miriam Ratliff, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David T. W. Jones, Felix Sahm
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Annika Hofmann, Nik Krajnc, Assunta Dal-Bianco, Christian J. Riedl, Tobias Zrzavy, Celia Lerma-Martin, Gregor Kasprian, Claudia E. Weber, Francesco Pezzini, Fritz Leutmezer, Paulus Rommer, Gabriel Bsteh, Michael Platten, Achim Gass, Thomas Berger, Philipp Eisele, Roberta Magliozzi, Lucas Schirmer, Simon Hametner
Summary: In this study, the researchers investigated the inflammatory activity in multiple sclerosis (MS) using iron-sensitive magnetic resonance imaging (MRI) and explored the cellular and molecular pathways of iron uptake and metabolism. They found that iron uptake was associated with specific myeloid cell subtypes and that patients with more paramagnetic rim lesions (PRLs) exhibited worse clinical outcomes. Additionally, the study identified the relevance of haptoglobin-bound hemoglobin in iron uptake and its correlation with soluble CD163 levels in cerebrospinal fluid. The findings suggest a potential link between haptoglobin genotype and clinical disability scores in MS.
ACTA NEUROPATHOLOGICA
(2023)
Editorial Material
Oncology
Binghao Zhao, Michael Kilian, Theresa Bunse, Michael Platten, Lukas Bunse
Summary: This article discusses the specific cellular mechanisms of T helper cells (THCs) in glioma immunology and contextualizes current advances in anti-glioma vaccination exploiting THCs.
Article
Oncology
Tobias Kessler, Daniel Schrimpf, Laura Doerner, Ling Hai, Leon D. Kaulen, Jakob Ito, Martin van den Bent, Martin Taphoorn, Alba A. Brandes, Ahmed Idbaih, Julien Domont, Paul M. Clement, Mario Campone, Martin Bendszus, Andreas von Deimling, Felix Sahm, Michael Platten, Wolfgang Wick, Antje Wick
Summary: The EORTC-26101 study investigated the efficacy of combination therapy with bevacizumab and lomustine versus lomustine alone in progressive glioblastoma. Molecular data from DNA methylation arrays and panel sequencing were analyzed to assess prognostic biomarkers. The study found that MGMT promoter methylation and RTK1 classifier assignment were prognostic factors, while NF1 mutation may predict response to bevacizumab treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Sophia Papaioannou, Jia-Xiang See, Mingeum Jeong, Carolina De La Torre, Volker Ast, Philipp-Sebastian Reiners-Koch, Ankita Sati, Carolin Mogler, Michael Platten, Adelheid Cerwenka, Ana Stojanovic
Summary: Liver sinusoidal endothelial cells (LSECs) respond to LPS and immune-derived signals, producing chemokines CCL2 and CXCL10. NK cells exposed to LSECs in vitro are primed for higher production of IFN-g in response to IL-12 and IL-18. In inflamed livers, NK cells are the major producers of IFN-g. This positive feedback loop of immune cell attraction and activation is regulated by LSECs and is important in liver inflammation.
Article
Clinical Neurology
Angelika Alonso, Josephine Kraus, Anne Ebert, Valeriya Nikolayenko, Mathieu Kruska, Vesile Sandikci, Hendrik Lesch, Daniel Duerschmied, Michael Platten, Stefan Baumann, Kristina Szabo, Ibrahim Akin, Christian Fastner
Summary: This study investigated the predictive power of left atrial parameters for atrial fibrillation in patients with acute ischemic stroke or transient ischemic attack, and found that left atrial area index was the best predictor and an independent risk factor.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
A. P. Abu Hejleh, K. Huck, K. Jaehne, C. L. Tan, T. Lanz, L. Epping, J. K. Sonner, S. G. Meuth, A. Henneberg, C. A. Opitz, C. Herold-Mende, F. Sahm, M. Platten, K. Sahm
Summary: The vascular niche of malignant gliomas plays a critical role in shaping the immunosuppressive brain tumor microenvironment. The blood-brain-barrier formed by specialized endothelial cells and perivascular cells controls the migration and function of immune cells. The metabolism of tryptophan to kynurenine has been identified as an important pathway suppressing immune responses. However, the expression of endothelial IDO1 does not significantly affect brain tumor immunity.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)