Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases

(2015) Myles J. Lewis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A volcanic explosion of autoantibodies in systemic lupus erythematosus: A diversity of 180 different antibodies found in SLE patients

(2015) Gal Yaniv et al.   AUTOIMMUNITY REVIEWS

Function of the Th17/Interleukin-17A Immune Response in Murine Lupus Nephritis

(2015) Tilman Schmidt et al.   Arthritis & Rheumatology

Lupus Nephritis: From Pathogenesis to Targets for Biologic Treatment

(2015) Yujuan Liu et al.   NEPHRON CLINICAL PRACTICE

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription

(2014) Joel M. Guthridge et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The complement system in systemic lupus erythematosus: an update

(2014) Jonatan Leffler et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetics of systemic lupus erythematosus: immune responses and end organ resistance to damage

(2014) Chao Dai et al.   CURRENT OPINION IN IMMUNOLOGY

The pathogenesis, diagnosis and treatment of lupus nephritis

(2014) Noa Schwartz et al.   CURRENT OPINION IN RHEUMATOLOGY

The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets

(2014) Wen-Hai Shao et al.   Expert Review of Clinical Immunology

IL-17 Promotes Murine Lupus

(2014) Gil Amarilyo et al.   JOURNAL OF IMMUNOLOGY

Correcting the expression of miRNA-155 represses PP2Ac and enhances the release of IL-2 in PBMCs of juvenile SLE patients

(2014) Y A Lashine et al.   LUPUS

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

(2014) Lunhua Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Unknown

(2014) Melinda Magna et al.   MOLECULAR MEDICINE

Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

(2014) Elizabeth M. Samuelson et al.   PLoS One

The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved

(2014) Ole Petter Rekvig et al.   Seminars in Immunopathology

Gene-gene interactions of IRF5, STAT4, IKZF1 and ETS1 in systemic lupus erythematosus

(2014) J. Dang et al.   TISSUE ANTIGENS

The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies: Independent and Interdependent Biomarkers of Disease

(2014) Sonal Mehra et al.   Journal of Immunology Research

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

(2014) Elmar Pieterse et al.   Frontiers in Immunology

Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase

(2014) Beili Shao et al.   Redox Biology

Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women

(2013) Hye-Soon Lee et al.   ANNALS OF THE RHEUMATIC DISEASES

Multiple Lupus-AssociatedITGAMVariants Alter Mac-1 Functions on Neutrophils

(2013) Yebin Zhou et al.   ARTHRITIS AND RHEUMATISM

Association study of TLR-9 polymorphisms and systemic lupus erythematosus in Northern Chinese Han population

(2013) Jihui Zhang et al.   GENE

PTPN22 in Autoimmunity: Different Cell and Different Way

(2013) Lionel B. Ivashkiv   IMMUNITY

Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse

(2013) Kristi A. Koelsch et al.   JOURNAL OF AUTOIMMUNITY

Protein Phosphatase 2A Enables Expression of Interleukin 17 (IL-17) through Chromatin Remodeling

(2013) Sokratis A. Apostolidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cgnz1allele confers kidney resistance to damage preventing progression of immune complex–mediated acute lupus glomerulonephritis

(2013) Yan Ge et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

(2013) Z. Hua et al.   JOURNAL OF IMMUNOLOGY

B Cell-Specific Loss of Lyn Kinase Leads to Autoimmunity

(2013) C. Lamagna et al.   JOURNAL OF IMMUNOLOGY

ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis

(2013) D. J. Caster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The CD11b-integrin (ITGAM) and systemic lupus erythematosus

(2013) SC Fagerholm et al.   LUPUS

Contributions of B cells to lupus pathogenesis

(2013) Allison Sang et al.   MOLECULAR IMMUNOLOGY

Unknown

(2013) Natalya Seredkina et al.   MOLECULAR MEDICINE

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Gene-function studies in systemic lupus erythematosus

(2013) José C. Crispín et al.   Nature Reviews Rheumatology

Abatacept in B7-1–Positive Proteinuric Kidney Disease

(2013) Chih-Chuan Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

(2013) Liliane Fossati-Jimack et al.   PLoS One

IL-10 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis

(2013) Ping Liu et al.   PLoS One

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

(2013) R. Baccala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population

(2013) Xian-Bo Zuo et al.   RHEUMATOLOGY INTERNATIONAL

B-cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumab and implications for study design

(2013) Venkat Reddy et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

(2013) Yun Deng et al.   PLoS Genetics

An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression

(2013) Shaofeng Wang et al.   PLoS Genetics

Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4

(2013) Harinder Manku et al.   PLoS Genetics

Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

(2013) Julio E. Molineros et al.   PLoS Genetics

Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus

(2013) Meena Shrivastav et al.   Frontiers in Immunology

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study

(2012) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

(2012) Mark A Jensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Fine mapping of Xq28: bothMECP2 and IRAK1contribute to risk for systemic lupus erythematosus in multiple ancestral groups

(2012) Kenneth M Kaufman et al.   ANNALS OF THE RHEUMATIC DISEASES

Thers1143679(R77H) lupus associated variant ofITGAM(CD11b) impairs complement receptor 3 mediated functions in human monocytes

(2012) Benjamin Rhodes et al.   ANNALS OF THE RHEUMATIC DISEASES

European genetic ancestry is associated with a decreased risk of lupus nephritis

(2012) Ilana B. Richman et al.   ARTHRITIS AND RHEUMATISM

Protein Kinase Cβ Is Required for Lupus Development in Sle Mice

(2012) David Oleksyn et al.   ARTHRITIS AND RHEUMATISM

Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004

(2012) Candace H. Feldman et al.   ARTHRITIS AND RHEUMATISM

Emerging and critical issues in the pathogenesis of lupus

(2012) Mariele Gatto et al.   AUTOIMMUNITY REVIEWS

Innate immune processes in lupus erythematosus

(2012) Martin Aringer et al.   CLINICAL IMMUNOLOGY

Lupus neutrophils

(2012) Jason S. Knight et al.   CURRENT OPINION IN RHEUMATOLOGY

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

(2012) Chuan Wang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

(2012) S Wang et al.   GENES AND IMMUNITY

Blimp-1 siRNA inhibits B cell differentiation and prevents the development of lupus in mice

(2012) Zhongqi Zhou et al.   HUMAN IMMUNOLOGY

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis

(2012) Peyman Rajabi et al.   INFLAMMATION RESEARCH

Cutting Edge: Protein Phosphatase 2A Confers Susceptibility to Autoimmune Disease through an IL-17-Dependent Mechanism

(2012) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

(2012) Samuel E. Vaughn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients

(2012) Marianne Frieri et al.   JOURNAL OF NEPHROLOGY

Relationship Between Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism and Systemic Lupus Erythematosus/Lupus Nephritis: A Systematic Review and Metaanalysis

(2012) T.-B. ZHOU et al.   JOURNAL OF RHEUMATOLOGY

Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice

(2012) Akiko Okamoto et al.   KIDNEY INTERNATIONAL

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice

(2012) T. Ishimoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

(2012) R. J. Brownlie et al.   Science Signaling

The genetics of lupus: a functional perspective

(2012) Sandra G Guerra et al.   ARTHRITIS RESEARCH & THERAPY

A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

(2012) Yukinori Okada et al.   PLoS Genetics

OX40/OX40L in systemic lupus erythematosus: Association with disease activity and lupus nephritis

(2011) MohamedN Farres et al.   ANNALS OF SAUDI MEDICINE

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

(2011) E. Sanchez et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genesBANK1andBLK

(2011) Casimiro Castillejo-López et al.   ANNALS OF THE RHEUMATIC DISEASES

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

(2011) Timothy B Niewold et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

(2011) Wenfeng Tan et al.   ARTHRITIS AND RHEUMATISM

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

(2011) Elena Sánchez et al.   ARTHRITIS AND RHEUMATISM

Macrophages and neutrophils in SLE—An online molecular catalog

(2011) Jacob Orme et al.   AUTOIMMUNITY REVIEWS

Recent advances in the genetics of systemic lupus erythematosus

(2011) Donna L Thibault Flesher et al.   Expert Review of Clinical Immunology

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

(2011) B Namjou et al.   GENES AND IMMUNITY

Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells

(2011) Elizabeth M Samuelson et al.   IMMUNOLOGY AND CELL BIOLOGY

Pathogenesis of systemic lupus erythematosus revisited 2011: End organ resistance to damage, autoantibody initiation and diversification, and HLA-DR

(2011) Shu Man Fu et al.   JOURNAL OF AUTOIMMUNITY

Th Subset Balance in Lupus Nephritis

(2011) Katsuhisa Miyake et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Hepatocyte growth factor preferentially activates the anti-inflammatory arm of NF-κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation

(2011) Cleide G. da Silva et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Tolerogenic function of Blimp-1 in dendritic cells

(2011) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Calcium/Calmodulin-Dependent Protein Kinase Type IV Is Essential for Mesangial Cell Proliferation and Lupus Nephritis

(2011) K. Ichinose et al.   JOURNAL OF IMMUNOLOGY

Type I Interferon and Systemic Lupus Erythematosus

(2011) Keith B. Elkon et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Autoimmune Disease Risk Allele of UBE2L3 in African American Patients with Systemic Lupus Erythematosus: A Recessive Effect Upon Subphenotypes

(2011) S. AGIK et al.   JOURNAL OF RHEUMATOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF- B-dependent pathway

(2011) M. Shimada et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Disturbances of apoptotic cell clearance in systemic lupus erythematosus

(2011) Wen-Hai Shao et al.   ARTHRITIS RESEARCH & THERAPY

Mechanisms of tissue injury in lupus nephritis

(2011) Tamara K Nowling et al.   ARTHRITIS RESEARCH & THERAPY

Lupus nephritis: current update

(2011) Ramesh Saxena et al.   ARTHRITIS RESEARCH & THERAPY

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production

(2011) Sharon A. Chung et al.   PLoS Genetics

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

(2011) Kimberly E. Taylor et al.   PLoS Genetics

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

Clearance of dying cells and systemic lupus erythematosus: the role of C1q and the complement system

(2010) Dror Mevorach   APOPTOSIS

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-α activity in lupus patients

(2010) Rafah Salloum et al.   ARTHRITIS AND RHEUMATISM

Association of a functional IRF7 variant with systemic lupus erythematosus

(2010) Qiong Fu et al.   ARTHRITIS AND RHEUMATISM

CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions

(2010) G. D. ROSS et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus

(2010) David L Morris et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies

(2010) Nadine Hövelmeyer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis

(2010) A. Chang et al.   JOURNAL OF IMMUNOLOGY

Promoter Insertion/Deletion in the IRF5 Gene Is Highly Associated with Susceptibility to Systemic Lupus Erythematosus in Distinct Populations, But Exerts a Modest Effect on Gene Expression in Peripheral Blood Mononuclear Cells

(2010) S. E. LOFGREN et al.   JOURNAL OF RHEUMATOLOGY

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

(2010) C-F. He et al.   LUPUS

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Association of IRF5 gene polymorphisms and lupus nephritis in a Chinese population

(2010) LIANXIANG QIN et al.   NEPHROLOGY

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

(2010) H. Machida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

(2010) A. Triantafyllopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice

(2010) R. Rodriguez-Manzanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus

(2010) Y.-J. Sheng et al.   RHEUMATOLOGY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

(2009) X. Kim-Howard et al.   ANNALS OF THE RHEUMATIC DISEASES

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

(2009) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling

(2009) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

Pathogenesis of kidney disease in systemic lupus erythematosus

(2009) Harini Bagavant et al.   CURRENT OPINION IN RHEUMATOLOGY

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations

(2009) J S Bates et al.   GENES AND IMMUNITY

Genetic associations of LYN with systemic lupus erythematosus

(2009) R Lu et al.   GENES AND IMMUNITY

ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai

(2009) Wanling Yang et al.   HUMAN MOLECULAR GENETICS

Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

(2009) S. Han et al.   HUMAN MOLECULAR GENETICS

Copy number variation at theFCGRlocus includesFCGR3A, FCGR2CandFCGR3Bbut notFCGR2AandFCGR2B

(2009) Willemijn B. Breunis et al.   HUMAN MUTATION

Mechanisms of costimulation

(2009) Arlene H. Sharpe   IMMUNOLOGICAL REVIEWS

Kallikrein genes are associated with lupus and glomerular basement membrane–specific antibody–induced nephritis in mice and humans

(2009) Kui Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferons Produced by Resident Renal Cells May Promote End-Organ Disease in Autoantibody-Mediated Glomerulonephritis

(2009) A.-M. Fairhurst et al.   JOURNAL OF IMMUNOLOGY

IFN Regulatory Factor 5 Is Required for Disease Development in the Fc RIIB-/-Yaa and Fc RIIB-/- Mouse Models of Systemic Lupus Erythematosus

(2009) C. Richez et al.   JOURNAL OF IMMUNOLOGY

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response

(2009) ED Papadimitraki et al.   LUPUS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Lupus nephritis: lessons from murine models

(2009) Anne Davidson et al.   Nature Reviews Rheumatology

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

(2009) Lisa F. Barcellos et al.   PLoS Genetics

The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation

(2008) Jens Lutz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys – a preliminary pilot study

(2008) H Ciferska et al.   LUPUS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics

Specificity of the STAT4 Genetic Association for Severe Disease Manifestations of Systemic Lupus Erythematosus

(2008) Kimberly E. Taylor et al.   PLoS Genetics