Article
Multidisciplinary Sciences
Mina-A Jhun, Michael Mendelson, Rory Wilson, Rahul Gondalia, Roby Joehanes, Elias Salfati, Xiaoping Zhao, Kim Valeska Emilie Braun, Anh Nguyet Do, Asa K. Hedman, Tao Zhang, Elena Carnero-Montoro, Jincheng Shen, Traci M. Bartz, Jennifer A. Brody, May E. Montasser, Jeff R. O'Connell, Chen Yao, Rui Xia, Eric Boerwinkle, Megan Grove, Weihua Guan, Pfeiffer Liliane, Paula Singmann, Martina Mueller-Nurasyid, Thomas Meitinger, Christian Gieger, Annette Peters, Wei Zhao, Erin B. Ware, Jennifer A. Smith, Klodian Dhana, Joyce van Meurs, Andre Uitterlinden, Mohammad Arfan Ikram, Mohsen Ghanbari, Deugi Zhi, Stefan Gustafsson, Lars Lind, Shengxu Li, Dianjianyi Sun, Tim D. Spector, Yii-der Ida Chen, Coleen Damcott, Alan R. Shuldiner, Devin M. Absher, Steve Horvath, Philip S. Tsao, Sharon Kardia, Bruce M. Psaty, Nona Sotoodehnia, Jordana T. Bell, Erik Ingelsson, Wei Chen, Abbas Dehghan, Donna K. Arnett, Melanie Waldenberger, Lifang Hou, Eric A. Whitsel, Andrea Baccarelli, Daniel Levy, Myriam Fornage, Marguerite R. Irvin, Themistocles L. Assimes
Summary: The study reveals strong and consistent associations between DNA methylation and blood lipid levels across multiple racial/ethnic groups, with specific and common CpG-lipid trait associations identified through a large-scale multi-ethnic epigenome-wide association study.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Peng Wu, Lin Ding, Xiaodong Li, Siyang Liu, Fanjun Cheng, Qing He, Mingzhong Xiao, Ping Wu, Hongyan Hou, Minghui Jiang, Pinpin Long, Hao Wang, Linlin Liu, Minghan Qu, Xian Shi, Qin Jiang, Tingting Mo, Wencheng Ding, Yu Fu, Shi Han, Xixiang Huo, Yingchun Zeng, Yana Zhou, Qing Zhang, Jia Ke, Xi Xu, Wei Ni, Zuoyu Shao, Jingzhi Wang, Panhong Liu, Zilong Li, Yan Jin, Fang Zheng, Fang Wang, Lei Liu, Wending Li, Kang Liu, Rong Peng, Xuedan Xu, Yuhui Lin, Hui Gao, Limei Shi, Ziyue Geng, Xuanwen Mu, Yu Yan, Kai Wang, Degang Wu, Xingjie Hao, Shanshan Cheng, Gaokun Qiu, Huan Guo, Kezhen Li, Gang Chen, Ziyong Sun, Xihong Lin, Xin Jin, Feng Wang, Chaoyang Sun, Chaolong Wang
Summary: A large genome-wide association study was conducted on Chinese individuals with COVID-19, identifying associations with genetic variants in FOXP4-AS1, ABO, and MEF2B outside of the 3p21.31 locus, suggesting important roles for adaptive immunity and the ABO blood group system in protecting against severe COVID-19.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chanwoo Kim, Young Jin Kim, Wanson Choi, Hye-Mi Jang, Mi Yeong Hwang, Sunwoo Jung, Hyunjoon Lim, Sang Bin Hong, Kyungheon Yoon, Bong-Jo Kim, Hyun-Young Park, Buhm Han
Summary: This study conducted research on human leukocyte antigen (HLA) gene variants in the major histocompatibility complex (MHC) region in the Korean population. By analyzing the associations between genetic variants and phenotypes, new association signals were discovered, and the heritability explained by MHC variants and genetic correlations among phenotypes were analyzed.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Tunc Morova, Yi Ding, Chia-Chi F. Huang, Funda Sar, Tommer Schwarz, Claudia Giambartolomei, Sylvan C. Baca, Dennis Grishin, Faraz Hach, Alexander Gusev, Matthew L. Freedman, Bogdan Pasaniuc, Nathan A. Lack
Summary: The majority of disease-associated single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) are located in non-coding regions. These variants can impact the binding of transcription factors to enhancer elements and alter gene expression. A high-throughput experimental method called snpSTARRseq was developed to functionally interrogate the activity of hundreds to thousands of non-coding variants on enhancer activity. Using this method, the researchers identified SNPs in prostate cancer risk-associated loci that significantly altered enhancer activity and provided a mechanism of action for certain GWAS risk regions.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Summary: Prognostication in CLL patients is challenging due to its heterogeneous clinical course. This study identifies two genomic locations associated with disease progression, highlighting the impact of constitutional genetic variation on CLL prognosis. Additionally, functional genes implicated in modulating key pathways in CLL pathogenesis are identified.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Ryosuke Okuno, Yu Inoue, Yuichi Hasebe, Toshio Igarashi, Mika Kawagishi-Hotta, Takaaki Yamada, Seiji Hasegawa
Summary: Research has found that some individuals have a genetic predisposition to skin aging, which may be associated with single nucleotide polymorphisms (SNPs). A genome-wide association study on Japanese women revealed that 5 SNPs within the COL5A3 gene were associated with wrinkles at the outer corners of the eyes, and 8q24.11 was associated with nasolabial folds. These SNPs have not been reported in other populations and may serve as markers for genetic predisposition to wrinkles and sagging.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Plant Sciences
Xiaojing Dang, Chunyu Jing, Mengyuan Zhang, Xinru Li, Qing Xu, Changmin Hu, Yulong Li, Ying Zhang, Dezheng Wang, Delin Hong, Jianhua Jiang
Summary: We investigated the phenotypic values of panicle elongation length (PEL) in 353 rice accessions across six environments. We identified and validated three significant quantitative trait loci (QTL) associated with PEL, namely qPEL4, qPEL6, and qPEL9, of which qPEL9 is a novel QTL. The allele PEL9(GG) was found to increase the PEL and outcrossing rate in the female parents of hybrid rice, with its frequency gradually increasing with latitude in the Northern Hemisphere. These findings will help improve the PEL of female parents in hybrid rice.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellstrom, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Voelker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguez-Manas, Francisco J. Garcia, Jose A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Summary: Low muscle strength is a heritable indicator of poor health in older people, with genetic loci associated with muscle weakness identified through genome-wide meta-analysis. Possible causal relationships with diabetes susceptibility, hematological parameters, and the immune system were also discovered using Mendelian randomization. The distinct mechanisms of muscle weakness from continuous strength were highlighted, shedding light on potential pathways involved in ageing.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J. B. van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I. Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T. Chan, Ann G. Zauber, Anna H. Wu, Annika Lindblom, Caroline Y. Um, Catherine M. Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D. Timothy Bishop, Daniel D. Buchanan, David R. Crosslin, David V. Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R. Schumacher, Gad Rennert, Graham G. Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K. Lee, Jennifer L. Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L. Hopper, Julie R. Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J. Gunter, Marco Matejcic, Mark A. Jenkins, Martha L. Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O. Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T. Campbell, Polly A. Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K. Pai, Robert E. Schoen, Robert S. Steinfelder, Robert W. Haile, Rosita Vandenputtelaar, Ross L. Prentice, Sebastien Kuery, Sergi Castellvi-Bel, Shoichiro Tsugane, Sonja I. Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J. Weinstein, Stephen J. Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A. Harrison, Taiki Yamaji, Temitope O. Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John D. Potter, Christopher I. Li, Reinier Meester, Victor Moreno, Jane C. Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G. Dunlop, Stephen B. Gruber, Richard B. Hayes, Paul D. P. Pharoah, Richard S. Houlston, Gail P. Jarvik, Ian P. Tomlinson, Wei Zheng, Douglas A. Corley, Ulrike Peters, Li Hsu
Summary: Polygenic risk scores (PRS) have the potential to guide precision colorectal cancer (CRC) prevention, but current PRS using European ancestry data do not perform well in non-European ancestry populations. In this study, Asian ancestry data was incorporated to improve the performance of PRS, and it was found to be significantly better in different racial and ethnic groups.
NATURE COMMUNICATIONS
(2023)
Article
Rheumatology
Junyan Qian, Ying Chen, Xinzhuang Yang, Qian Wang, Jiuliang Zhao, Xiaoyue Deng, Yufang Ding, Shengjie Li, Yongtai Liu, Zhuang Tian, Juan Shen, Qijun Liao, Yanhong Wang, Xianbo Zuo, Xuejun Zhang, Mengtao Li, Yong Cui, Xueqing Yu, Xiaofeng Zeng
Summary: This study investigated the genetic signatures of SLE-associated PAH and identified HLA-DQA1*03:02 as a novel genetic variant associated with SLE-associated PAH susceptibility. Patients with this allele had lower rates of target role achievement and survival, highlighting the importance of regular monitoring and early intervention for potential PAH in SLE patients with this allele.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kwang Yoon Kim, Jung Oh Kim, Young-Sang Kim, Ja-Eun Choi, Jae-Min Park, Kunhee Han, Da-Hyun Park, Yon Chul Park, Bom Taeck Kim, Kyung-Won Hong
Summary: The study identified three genetic loci (GGT1, ZNF827, and HNF1A) significantly associated with ALD risk, with HNF1A rs1183910 showing the strongest protective effect in light drinkers. It was also found that the amount of alcohol consumed may alter the expression of genes contributing to ALD development.
Article
Genetics & Heredity
Zhikun Yang, Zhewei Zhang, Yining Zhu, Guangwei Yuan, Jingyun Yang, Weihong Yu
Summary: This study used a two-sample Mendelian randomization method to prioritize genes associated with intraocular pressure (IOP). The results identified 19 genes (using GTEx data) and 25 genes (using CAGE data) that are pleiotropically associated with IOP. Additionally, a transcriptome-wide association study identified 18 genes whose expression levels were associated with IOP. These findings suggest the importance of the 17q21.31 genomic region in the regulation of IOP.
Article
Biochemical Research Methods
Richard J. Packer, Alex T. Williams, William Hennah, Micaela T. Eisenberg, Nick Shrine, Katherine A. Fawcett, Willow Pearson, Anna L. Guyatt, Ahmed Edris, Edward J. Hollox, Mikko Marttila, Balasubramanya S. Rao, John Raymond Bratty, Louise Wain, Frank Dudbridge, Martin D. Tobin
Summary: DeepPheWAS is an R package that allows for phenome-wide association studies by creating curated composite phenotypes and integrating quantitative phenotypes from primary care data, as well as disease progression and drug response phenotypes. It provides tools for efficient analysis of associations with genetic input under any genetic model, including optional sex-stratified analysis and phenotype development.
Article
Agronomy
Shilei Liu, Wenli Zou, Xiang Lu, Jianmin Bian, Haohua He, Jingguang Chen, Guoyou Ye
Summary: The study identified QTLs associated with Zn2+ concentrations in both shoots and grains of rice, with some QTLs affecting Zn2+ concentration in both tissues. Candidate gene analysis suggested that LOC_Os02g06010 may play a crucial role in zinc accumulation in indica rice.
Article
Biochemical Research Methods
Xinyue Wang, Leonard Dervishi, Wentao Li, Erman Ayday, Xiaoqian Jiang, Jaideep Vaidya
Summary: This work introduces an efficient framework for conducting collaborative GWAS on distributed datasets, maintaining data privacy without compromising the accuracy of the results. The proposed method reduces communication and computational overheads using a two-step strategy and iterative and sampling techniques. Logistic regression is used as the statistical method in this approach. The empirical evaluation showcases the efficiency and applicability of this method in different study heterogeneity and skewed phenotype distributions.
Review
Rheumatology
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Summary: This study reports a case of a 49-year-old female who experienced a flare of adult-onset Still's disease (AOSD) after receiving the first dose of BNT162b2 mRNA COVID-19 vaccination. The patient presented with fever and nausea 4 days after vaccination and was ultimately treated with steroid pulse therapy. The study also discusses possible mechanisms linking vaccination with a flare of AOSD.
CLINICAL RHEUMATOLOGY
(2022)
Review
Immunology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease with a high heritability of up to 66%, with most risk variants residing in non-coding regions. Recent studies have identified dozens of new SLE loci and integrated GWAS signals with other biological resources in genetic associations. The research also explores genetic risk scores for SLE and their associations with clinical features, as well as variant-driven pathogenetic functions and future challenges in genetic studies on SLE.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: By combining genome-wide association studies and transcriptome-wide association studies, we identified candidate genes associated with systemic lupus erythematosus and discovered a strong association between the CD83 gene and SLE. We also identified 276 gene candidates at the 110 SLE loci and demonstrated a regulatory effect of a putative causal variant on the ACAP1 gene.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Oncology
Ji-Won Kim, Eunyoung A. Lee, Hyoun-Ah Kim, Chang-Hee Suh, Ju-Yang Jung
Summary: This study aimed to analyze the clinical features, outcomes, and reasons for discontinuing TNF inhibitor therapy in older patients with ankylosing spondylitis (AS). Data from a nationwide registry were used to compare clinical variables and outcomes. The study found that older patients had a higher incidence of hypertension and diabetes, and lower drug retention rates. However, improvements in disease activity and manifestations were comparable between older and younger patients.
Article
Multidisciplinary Sciences
Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: This study provides evidence that Rho-mediated transcription termination can occur via three kinetically different routes, shedding light on the mechanism of transcription termination.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ju-Yang Jung, Ji-Won Kim, Sang-Won Lee, Wook-Young Baek, Hyoun-Ah Kim, Chang-Hee Suh
Summary: This study evaluates the clinical value of Immunoglobulin gamma-3 chain C (IGHG3) by measuring and comparing its levels in different body fluids of patients with systemic lupus erythematosus (SLE). The levels of IGHG3 in saliva, serum, and urine were measured and analyzed in patients with SLE and healthy controls. It was found that IGHG3 levels were increased in the saliva, serum, and urine of patients with SLE, and correlated with certain clinical characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eunho Song, Seungha Hwang, Palinda Ruvan Munasingha, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: In this study on bacterial Rho factor-dependent terminators, it was found that the three Rho-dependent termination routes operate compatibly and their efficiency depends on the termination pauses. The most abundant route involves Rho catching up with a paused RNA polymerase, leading to simultaneous release of transcript RNA and template DNA. The fastest route results in RNA-only release and recycling of RNAP, while the slowest route facilitates simultaneous releases. The termination efficiency of stand-by Rho positively correlates with pause duration, contrary to previous speculation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Rheumatology
Young-Chang Kwon, Eunji Ha, Hyuk-Hee Kwon, Dae Jin Park, Jung-Min Shin, Young Bin Joo, Won Tae Chung, Dae-Hyun Yoo, Hye-Soon Lee, Kwangwoo Kim, Sang-Cheol Bae, So-Young Bang
Summary: This study aimed to identify the genetic risk load in SLE patients using clinical and serological manifestations. The results showed that a high genetic risk score was associated with SLE manifestations and predicted renal disorders and diverse clinical phenotypes.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Immunology
Ye-Ji Kim, Jeein Oh, Soohan Jung, Chan Johng Kim, Jinyong Choi, Yoon Kyung Jeon, Hyun Jik Kim, Ji-Won Kim, Chang-Hee Suh, Yoontae Lee, Sin-Hyeog Im, Shane Crotty, Youn Soo Choi
Summary: Communication between CD4 T cells and cognate B cells is crucial for the maturation of GC-TFH cells and the induction of CD4 T cell-dependent humoral immune response. Mef2d regulates the formation of B:T synapse and the production of IL-21, thus controlling the differentiation of CD4 T cells into GC-TFH cells and the antibody production by B cells. The expression of MEF2D gene is inversely correlated with autoimmune parameters in SLE patients.
SCIENCE IMMUNOLOGY
(2023)
Review
Primary Health Care
Sami Lee, Jihan Kim, Jong Sung Kim
Summary: Due to individual differences in alcohol metabolism, it is inappropriate to use a uniform standard for evaluating drinking status. In Korea, a guideline based on alcohol metabolism capabilities, as indicated by facial flushing response, has been established for moderate drinking. This study aimed to identify the drinking habits of Koreans according to this guideline. The results confirmed that approximately one-third of the population experienced facial flushing when drinking alcohol, and different drinking habits were observed within the same age and gender groups based on the presence of facial flushing. The accurate evaluation of drinking habits is challenging without data on facial flushing from large-scale studies or various medical examinations. It is crucial to ensure the confirmation of facial flushing during medical treatment or examinations to accurately evaluate drinking habits and prevent and resolve drinking problems.
KOREAN JOURNAL OF FAMILY MEDICINE
(2023)
Article
Rheumatology
Wook-Young Baek, Sung-Min Lee, Sang-Won Lee, Chang-Hee Suh
Summary: This study aimed to evaluate the effect of rosuvastatin on inflammatory responses in lupus-prone mice. The results showed that rosuvastatin can decrease serum cholesterol levels and reduce the expression of inflammatory cytokines in lymphoid organs and kidneys. However, it did not improve clinical manifestations, autoantibody titres, or renal histopathology.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Endocrinology & Metabolism
Chang-Hee Suh
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Gunhyoung Lim, Seungha Hwang, Kilwon Yu, Jin Young Kang, Changwon Kang, Sungchul Hohng
Summary: In this single-molecule study, researchers discovered that actively transcribing RNA polymerase can act as an efficient sensor for DNA double-strand breaks (DSBs), resulting in the formation of R-loops. The efficiency of R-loop formation is influenced by DNA end structures and can interfere with transcription and prevent subsequent rounds of transcription. These findings provide valuable insights into the initiation of DSB repair on transcription templates across different organisms.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Chang -Hee Suh, Young-Min Ye, Hyoun-Ah Kim
Summary: This study compared the occurrence of adverse events and disease flares after COVID-19 and influenza vaccination in patients with autoimmune rheumatic diseases (ARDs). The results showed that the rates of adverse events and disease flares were significantly higher after COVID-19 vaccination than after influenza vaccination. Previous allergic reactions to other vaccines were the only factor associated with the occurrence of adverse events. There was no difference in the post-vaccine response between mixed and matched vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)